Major Histocompatibility Complex Genomics and Human Disease

Influence of HLA-C Expression Level on HIV Control

(2013) R. Apps et al.   SCIENCE

Contagious cancer: Lessons from the devil and the dog

(2012) Katherine Belov   BIOESSAYS

A Genome-Wide Association Study for Coronary Artery Disease Identifies a Novel Susceptibility Locus in the Major Histocompatibility Complex

(2012) Robert W. Davies et al.   Circulation-Cardiovascular Genetics

Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

Immune self-reactivity triggered by drug-modified HLA-peptide repertoire

(2012) Patricia T. Illing et al.   NATURE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

Genetics of gene expression in primary immune cells identifies cell type–specific master regulators and roles of HLA alleles

(2012) Benjamin P Fairfax et al.   NATURE GENETICS

A CD74-dependent MHC class I endolysosomal cross-presentation pathway

(2012) Genc Basha et al.   NATURE IMMUNOLOGY

High-throughput, high-fidelity HLA genotyping with deep sequencing

(2012) C. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation

(2012) U. S. Rajapaksa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infection

(2012) Jinghe Huang et al.   Retrovirology

High-Density SNP Mapping of the HLA Region Identifies Multiple Independent Susceptibility Loci Associated with Selective IgA Deficiency

(2012) Ricardo C. Ferreira et al.   PLoS Genetics

Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA

(2012) Kouyuki Hirayasu et al.   PLoS Pathogens

Drug Hypersensitivity and Human Leukocyte Antigens of the Major Histocompatibility Complex

(2011) Mandvi Bharadwaj et al.   Annual Review of Pharmacology and Toxicology

HLA*IMP—an integrated framework for imputing classical HLA alleles from SNP genotypes

(2011) Alexander T. Dilthey et al.   BIOINFORMATICS

Next-generation sequencing for HLA typing of class I loci

(2011) Rachel L Erlich et al.   BMC GENOMICS

Sequence Capture and Next Generation Resequencing of the MHC Region Highlights Potential Transplantation Determinants in HLA Identical Haematopoietic Stem Cell Transplantation

(2011) J. Proll et al.   DNA RESEARCH

Early epigenetic events regulate the adaptive immune response gene CIITA

(2011) Ninad T. Mehta et al.   Epigenetics

Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis

(2011) J-P Achkar et al.   GENES AND IMMUNITY

Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex

(2011) C. Vandiedonck et al.   GENOME RESEARCH

The emerging role of HLA-C in HIV-1 infection

(2011) Deanna A. Kulpa et al.   IMMUNOLOGY

Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome

(2011) Tai-Ming Ko et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Single Autoimmune T Cell Receptor Recognizes More Than a Million Different Peptides

(2011) Linda Wooldridge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Primordial Linkage of  2-Microglobulin to the MHC

(2011) Y. Ohta et al.   JOURNAL OF IMMUNOLOGY

Mutagenesis of Beryllium-Specific TCRs Suggests an Unusual Binding Topology for Antigen Recognition

(2011) N. A. Bowerman et al.   JOURNAL OF IMMUNOLOGY

Maternal KIR and fetal HLA-C: a fine balance

(2011) Olympe Chazara et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection

(2011) Mathias Lichterfeld et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential microRNA regulation of HLA-C expression and its association with HIV control

(2011) Smita Kulkarni et al.   NATURE

The genome sequence of Atlantic cod reveals a unique immune system

(2011) Bastiaan Star et al.   NATURE

Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1

(2011) Chiea Chuen Khor et al.   NATURE GENETICS

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

(2011) David M Evans et al.   NATURE GENETICS

Mice completely lacking immunoproteasomes show major changes in antigen presentation

(2011) Eleanor Z Kincaid et al.   NATURE IMMUNOLOGY

Evidence for More than One Parkinson's Disease-Associated Variant within the HLA Region

(2011) Erin M. Hill-Burns et al.   PLoS One

The dominantly expressed class I molecule of the chicken MHC is explained by coevolution with the polymorphic peptide transporter (TAP) genes

(2011) B. A. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour Necrosis Factor Gene Polymorphism and Disease Prevalence

(2011) T. Qidwai et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

The Shaping of Modern Human Immune Systems by Multiregional Admixture with Archaic Humans

(2011) L. Abi-Rached et al.   SCIENCE

A multi-site study using high-resolution HLA genotyping by next generation sequencing

(2011) C. L. Holcomb et al.   TISSUE ANTIGENS

Natural killer cell responses during viral infections: flexibility and conditioning of innate immunity by experience

(2011) Silvia M Vidal et al.   Current Opinion in Virology

Trans-eQTLs Reveal That Independent Genetic Variants Associated with a Complex Phenotype Converge on Intermediate Genes, with a Major Role for the HLA

(2011) Rudolf S. N. Fehrmann et al.   PLoS Genetics

Linkage disequilibrium and age of HLA region SNPs in relation to classic HLA gene alleles within Europe

(2010) Irina Evseeva et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Next-generation sequencing: the solution for high-resolution, unambiguous human leukocyte antigen typing

(2010) C. Lind et al.   HUMAN IMMUNOLOGY

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Leukocyte Immunoglobulin-Like Receptors Maintain Unique Antigen-Presenting Properties of Circulating Myeloid Dendritic Cells in HIV-1-Infected Elite Controllers

(2010) J. Huang et al.   JOURNAL OF VIROLOGY

Cheetah Paradigm Revisited: MHC Diversity in the World's Largest Free-Ranging Population

(2010) Aines Castro-Prieto et al.   MOLECULAR BIOLOGY AND EVOLUTION

Fine-scale recombination rate differences between sexes, populations and individuals

(2010) Augustine Kong et al.   NATURE

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Multiple sclerosis, vitamin D, and HLA-DRB1*15

(2010) L. Handunnetthi et al.   NEUROLOGY

The IMGT/HLA database

(2010) J. Robinson et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of HLA-DP2 and implications for chronic beryllium disease

(2010) S. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide antagonism as a mechanism for NK cell activation

(2010) L. Fadda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

First-Class Control of HIV-1

(2010) A. J. McMichael et al.   SCIENCE

Suppression of Antitumor Immunity by Stromal Cells Expressing Fibroblast Activation Protein- 

(2010) M. Kraman et al.   SCIENCE

Brd2disruption in mice causes severe obesity without Type 2 diabetes

(2009) Fangnian Wang et al.   BIOCHEMICAL JOURNAL

Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes

(2009) P. J. Norman et al.   GENOME RESEARCH

Rapid high-throughput human leukocyte antigen typing by massively parallel pyrosequencing for high-resolution allele identification

(2009) Christian Gabriel et al.   HUMAN IMMUNOLOGY

Mechanisms of copy number variation and hybrid gene formation in the KIR immune gene complex

(2009) James A. Traherne et al.   HUMAN MOLECULAR GENETICS

Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes

(2009) Emily S. W. Wong et al.   IMMUNOGENETICS

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

High-resolution, high-throughput HLA genotyping by next-generation sequencing

(2009) G. Bentley et al.   TISSUE ANTIGENS

Expression of the Multiple Sclerosis-Associated MHC Class II Allele HLA-DRB1*1501 Is Regulated by Vitamin D

(2009) Sreeram V. Ramagopalan et al.   PLoS Genetics

A Statistical Method for Predicting Classical HLA Alleles from SNP Data

(2008) Stephen Leslie et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis

(2008) Eleni M Tomazou et al.   BMC Medical Genomics

Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project

(2008) Roger Horton et al.   IMMUNOGENETICS

The extended human leukocyte receptor complex: diverse ways of modulating immune responses

(2008) Alexander David Barrow et al.   IMMUNOLOGICAL REVIEWS

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

HLA class I alleles tag HLA-DRB1*1501 haplotypes for differential risk in multiple sclerosis susceptibility

(2008) M. J. Chao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new theory of MHC evolution: beyond selection on the immune genes

(2008) C. van Oosterhout   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MHC-correlated mate choice in humans: A review

(2008) Jan Havlicek et al.   PSYCHONEUROENDOCRINOLOGY

The evolution of NK cell diversity

(2008) Andrew P. Makrigiannis et al.   SEMINARS IN IMMUNOLOGY