HIV Control Is Mediated in Part by CD8+ T-Cell Targeting of Specific Epitopes

Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

(2013) Andrew L. Ferguson et al.   IMMUNITY

Increased Sequence Coverage through Combined Targeting of Variant and Conserved Epitopes Correlates with Control of HIV Replication

(2013) J. Sunshine et al.   JOURNAL OF VIROLOGY

Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins

(2013) C. L. Boutwell et al.   JOURNAL OF VIROLOGY

Vaccine-elicited Human T Cells Recognizing Conserved Protein Regions Inhibit HIV-1

(2013) Nicola Borthwick et al.   MOLECULAR THERAPY

Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine

(2013) Scott M. Hammer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nef-Specific CD8+ T Cell Responses Contribute to HIV-1 Immune Control

(2013) Emily Adland et al.   PLoS One

A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

(2013) István Bartha et al.   eLife

HIV and HLA Class I: An Evolving Relationship

(2012) Philip J.R. Goulder et al.   IMMUNITY

The Choreography of HIV-1 Proteolytic Processing and Virion Assembly

(2012) Sook-Kyung Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aminopeptidase Substrate Preference Affects HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-Infected Individuals

(2012) S. C. Zhang et al.   JOURNAL OF IMMUNOLOGY

Temporal Association of HLA-B*81:01- and HLA-B*39:10-Mediated HIV-1 p24 Sequence Evolution with Disease Progression

(2012) R. S. Ntale et al.   JOURNAL OF VIROLOGY

HIV Control through a Single Nucleotide on the HLA-B Locus

(2012) H. N. Kloverpris et al.   JOURNAL OF VIROLOGY

Correlates of Protective Cellular Immunity Revealed by Analysis of Population-Level Immune Escape Pathways in HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

Elite Controllers with Low to Absent Effector CD8+ T Cell Responses Maintain Highly Functional, Broadly Directed Central Memory Responses

(2012) Z. M. Ndhlovu et al.   JOURNAL OF VIROLOGY

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

(2012) Huabiao Chen et al.   NATURE IMMUNOLOGY

CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control

(2012) Beatriz Mothe et al.   PLoS One

HIV-Specific Cytolytic CD4 T Cell Responses During Acute HIV Infection Predict Disease Outcome

(2012) D. Z. Soghoian et al.   Science Translational Medicine

Escape from highly effective public CD8+ T-cell clonotypes by HIV

(2011) M. C. Iglesias et al.   BLOOD

pROC: an open-source package for R and S+ to analyze and compare ROC curves

(2011) Xavier Robin et al.   BMC BIOINFORMATICS

Mutations in a Dominant Nef Epitope of Simian Immunodeficiency Virus Diminish TCR:Epitope Peptide Affinity but not Epitope Peptide:MHC Class I Binding

(2011) E. M. Cale et al.   JOURNAL OF IMMUNOLOGY

Definition of the viral targets of protective HIV-1-specific T cell responses

(2011) Beatriz Mothe et al.   Journal of Translational Medicine

HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control

(2011) H. N. Kloverpris et al.   JOURNAL OF VIROLOGY

HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

(2011) S. Ranasinghe et al.   JOURNAL OF VIROLOGY

Progression to AIDS in South Africa Is Associated with both Reverting and Compensatory Viral Mutations

(2011) Kuan-Hsiang Gary Huang et al.   PLoS One

Coordinate linkage of HIV evolution reveals regions of immunological vulnerability

(2011) V. Dahirel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes

(2010) Arthur H. Robbins et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HIV Immune Escape at an Immunodominant Epitope in HLA-B*27-Positive Individuals Predicts Viral Load Outcome

(2010) P. Ammaranond et al.   JOURNAL OF IMMUNOLOGY

Virus-Specific CD8+ T-Cell Responses Better Define HIV Disease Progression than HLA Genotype

(2010) W. L. Dinges et al.   JOURNAL OF VIROLOGY

Crystal structure of HIV-1 Tat complexed with human P-TEFb

(2010) Tahir H. Tahirov et al.   NATURE

Structural basis for cooperative RNA binding and export complex assembly by HIV Rev

(2010) Matthew D Daugherty et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

(2010) A. Theodossis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

(2010) T. Zhou et al.   SCIENCE

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

The capsid-spacer peptide 1 Gag processing intermediate is a dominant-negative inhibitor of HIV-1 maturation

(2010) Mary Ann Checkley et al.   VIROLOGY

Induction of novel CD8+ T-cell responses during chronic untreated HIV-1 infection by immunization with subdominant cytotoxic T-lymphocyte epitopes

(2009) Henrik Kloverpris et al.   AIDS

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

(2009) Owen Pornillos et al.   CELL

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

(2009) Hayley Crawford et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

(2009) M. Pancera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The implications of patterns in HIV diversity for neutralizing antibody induction and susceptibility

(2009) Bette Korber et al.   Current Opinion in HIV and AIDS

HLA class I supertypes: a revised and updated classification

(2008) John Sidney et al.   BMC IMMUNOLOGY

A Nonprogressive Clinical Course in HIV‐Infected Individuals Expressing Human Leukocyte Antigen B57/5801 Is Associated with Preserved CD8+T Lymphocyte Responsiveness to the HW9 Epitope in Nef

(2008) Marjon Navis et al.   JOURNAL OF INFECTIOUS DISEASES

Transmission and Long-Term Stability of Compensated CD8 Escape Mutations

(2008) A. Schneidewind et al.   JOURNAL OF VIROLOGY

Marked Epitope- and Allele-Specific Differences in Rates of Mutation in Human Immunodeficiency Type 1 (HIV-1) Gag, Pol, and Nef Cytotoxic T-Lymphocyte Epitopes in Acute/Early HIV-1 Infection

(2008) Z. L. Brumme et al.   JOURNAL OF VIROLOGY

Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial

(2008) Susan P Buchbinder et al.   LANCET

Broad and Gag-Biased HIV-1 Epitope Repertoires Are Associated with Lower Viral Loads

(2008) Morgane Rolland et al.   PLoS One