l -tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK-TRAF6 interactions and inhibiting NF-κB and MAPK pathways

Reversal of Osteoporotic Activity by Endothelial Cell-Secreted Bone Targeting and Biocompatible Exosomes

(2019) Hongyuan Song et al.   NANO LETTERS

Structure-based development of an osteoprotegerin-like glycopeptide that blocks RANKL/RANK interactions and reduces ovariectomy-induced bone loss in mice

(2018) Chao Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Levo-Tetrahydropalmatine Attenuates Progression of Abdominal Aortic Aneurysm in an Elastase Perfusion Rat Model via Suppression of Matrix Metalloproteinase and Monocyte Chemotactic Protein-1

(2018) Xin Wang et al.   MEDICAL SCIENCE MONITOR

A Matrine Derivative M54 Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss by Targeting Ribosomal Protein S5

(2018) Zhi Xin et al.   Frontiers in Pharmacology

18β-Glycyrrhetinic Acid Inhibits Osteoclastogenesis In Vivo and In Vitro by Blocking RANKL-Mediated RANK–TRAF6 Interactions and NF-κB and MAPK Signaling Pathways

(2018) Xiao Chen et al.   Frontiers in Pharmacology

Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis

(2017) Xiao Chen et al.   FASEB JOURNAL

Carnosic acid attenuates RANKL-induced oxidative stress and osteoclastogenesis via induction of Nrf2 and suppression of NF-κB and MAPK signalling

(2017) Dinesh Thummuri et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Matrine derivate MASM uncovers a novel function for ribosomal protein S5 in osteoclastogenesis and postmenopausal osteoporosis

(2017) Xiao Chen et al.   Cell Death & Disease

L-Tetrahydropalmatine alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice

(2016) Hai-Hui Zhou et al.   NEUROREPORT

Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat

(2016) Zhuo Qu et al.   PHYSIOLOGY & BEHAVIOR

Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways

(2015) Feng-Lai Yuan et al.   BONE

The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis

(2015) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A look behind the scenes: the risk and pathogenesis of primary osteoporosis

(2015) Gretl Hendrickx et al.   Nature Reviews Rheumatology

Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling

(2015) Dinesh Thummuri et al.   PHARMACOLOGICAL RESEARCH

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

NF-κB signaling and bone resorption

(2013) Y. Abu-Amer   OSTEOPOROSIS INTERNATIONAL

Bone mass density selectively correlates with serum markers of oxidative damage in post-menopausal women

(2012) Carlo Cervellati et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

l-Tetrahydropalmatine, an Active Component of Corydalis yanhusuo W.T. Wang, Protects against Myocardial Ischaemia-Reperfusion Injury in Rats

(2012) Yi Han et al.   PLoS One

Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis

(2012) Abdul M. Tyagi et al.   PLoS One

Estrogen and the skeleton

(2012) Sundeep Khosla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Novel pharmacotherapeutic treatments for cocaine addiction

(2011) Daryl Shorter et al.   BMC Medicine

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Antiresorptive therapies for osteoporosis: a clinical overview

(2011) Jian Sheng Chen et al.   Nature Reviews Endocrinology

Protective effects of tetrahydropalmatine against γ-radiation induced damage to human endothelial cells

(2010) Jing Yu et al.   LIFE SCIENCES

Reciprocal roles between caffeine and estrogen on bone via differently regulating cAMP/PKA pathway: The possible mechanism for caffeine-induced osteoporosis in women and estrogen’s antagonistic effects

(2009) Yi Zhou et al.   MEDICAL HYPOTHESES

Denosumab for Prevention of Fractures in Postmenopausal Women With Osteoporosis

(2009) Steven R. Cummings et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY