Article
Pharmacology & Pharmacy
Lidia E. W. Spelta, Yuli Y. S. Torres, Sarah C. W. S. E. F. de Oliveira, Mauricio Yonamine, Alexis Bailey, Rosana Camarini, Raphael C. T. Garcia, Tania Marcourakis
Summary: This study demonstrates that cocaine use induces plastic changes in the hippocampal cholinergic muscarinic system, while withdrawal leads to a resetting of the system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Giorgia Caspani, Viktoria Sebok, Nowshin Sultana, Jonathan R. Swann, Alexis Bailey
Summary: Metabolomics can elucidate the biochemical impact of substance abuse, understand the addiction cycle, and predict prognosis for recovery or relapse.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn Bauersachs, Merie Nassar, Charlotte Piette, Priit Pruunsild, Yan-Wei Tan, Benoit Forget, Nicolas Heck, Jocelyne Caboche, Laurent Venance, Peter Vanhoutte, Hilmar Bading
Summary: Npas4 is a crucial regulator of medium spiny neuron function, affecting spine density and electrophysiological parameters, as well as cocaine-induced locomotion magnitude. Its induction is calcium-dependent and independent of common kinase pathways, controlling a regulon that includes synaptic molecules.
Article
Neurosciences
Agustin Zapata, Carl R. Lupica
Summary: Animal and human studies suggest that cannabis can increase cocaine seeking and is associated with impulse control deficits, possibly through involvement of the CB1 receptors. The CB1 receptors in the Lateral Habenula (LHb) play a role in impulsivity deficits, highlighting a potential therapeutic target for substance use disorders.
Article
Behavioral Sciences
Kathleen M. Kantak, Carissa Stots, Elon Mathieson, Camron D. Bryant
Summary: Research using reduced complexity cross (RCC) strategy has accelerated the discovery of genes related to cocaine addiction traits in rat substrains. By validating differences in compulsive-like behavior and cocaine self-administration traits between two substrains, the effectiveness of using RCC approach has been confirmed.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Psychology, Multidisciplinary
Mark Leary, Kirrilly M. Pursey, Antonio Verdejo-Garcia, Tracy L. Burrows
Summary: Research on food addiction has been steadily growing, but interventions for self-reported FA are limited in number and efficacy. This review aimed to examine the effectiveness of different interventions on reducing FA symptoms and changing diagnosis, with some interventions showing potential for reducing self-reported FA outcomes in adults. Further research on longer-term efficacy and larger sample sizes is needed to provide clearer recommendations for practice.
BEHAVIORAL SCIENCES
(2021)
Article
Substance Abuse
Laura Brandt, Thomas Chao, Sandra D. Comer, Frances R. Levin
Summary: Despite ongoing challenges in finding effective pharmacotherapies for cocaine use disorder, existing medications show promise with further investigation into refined treatment metrics and combination therapies with behavioral/psychosocial interventions.
Article
Psychiatry
Daniela Benzano, Felipe Ornell, Jaqueline Bohrer Schuch, Flavio Pechansky, Anne Orgler Sordi, Lisia von Diemen, Felix Henrique Paim Kessler
Summary: Individuals with substance use disorder are at higher risk of COVID-19 severity due to various risk factors such as smoking, hypertension, respiratory issues, and homelessness. Multiple risk factors were observed in the sample, indicating a potentially worse prognosis for COVID-19 in this population.
PSYCHIATRY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Kathrine Louise Jensen, Soren Brogger Jensen, Kenneth Lindegaard Madsen
Summary: Psychostimulant use disorder is a major global health issue with no effective pharmacological treatments available. This review provides an overview of pharmacological treatments targeting different aspects of psychostimulant addiction, including the dopamine system, the glutamate system, and the severe side effects of quitting long-term use. Promising results have been found with drugs modulating the dopamine system, cognitive enhancers, and drugs targeting the glutamate system, but further research is needed for sufficient evidence of efficacy and tolerability.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Leonardo da Silva Neto, Angelica Faleiros da Silva Maia, Adriana Martins Godin, Paulo Sergio de Almeida Augusto, Raissa Lima Goncalves Pereira, Sordaini Maria Caligiorne, Rosemeire Brondi Alves, Simone Odilia Antunes Fernandes, Valbert Nascimento Cardoso, Gisele Assis Castro Goulart, Felipe Terra Martins, Maila de Castro Lourenco das Neves, Frederico Duarte Garcia, Angelo de Fatima
Summary: The study introduces two novel calix[n]arene-based anti-cocaine immunogens (V4N2 and V8N2) and evaluates their preclinical efficacy. The immunogens induce high titers of cocaine antibodies and modify the biodistribution of a cocaine analogue, reducing cocaine-induced behavior. These findings demonstrate the potential of V4N2 and V8N2 as immunogens for the treatment of cocaine use disorder.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Substance Abuse
Violaine Mongeau-Perusse, Suzanne Brissette, Julie Bruneau, Patricia Conrod, Simon Dubreucq, Guillaume Gazil, Emmanuel Stip, Didier Jutras-Aswad
Summary: This study tested the efficacy of CBD for reducing craving and preventing relapse in people with CUD. However, the findings showed that CBD treatment did not reduce cocaine craving or relapse among participants being treated for CUD.
Article
Neurosciences
Eric Y. Choi, Daniela Franco, Catherine A. Stapf, Madeleine Gordin, Amanda Chow, Kara K. Cover, Ramesh Chandra, Mary Kay Lobo
Summary: Substance use disorder is a chronic disease with significant impact on global disability. This study investigates the molecular and functional changes in the NAc associated with cocaine exposure, specifically in D1-MSNs and D2-MSNs. Using CRISPR tools, the researchers mimic the expression patterns of Nab2 and Egr3 in these neurons and shed light on their role in cocaine action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Lauren E. Mueller, Melissa J. Sharpe, Thomas A. Stalnaker, Andrew M. Wikenheiser, Geoffrey Schoenbaump
Summary: Substance use disorders are associated with maladaptive behavior due to drug-induced neural alterations affecting the encoding of state-specific information in the dorsomedial striatum. Prior cocaine experience can lead to enhanced encoding of specific rules in the DMS, resulting in slower decision-making behavior.
JOURNAL OF NEUROSCIENCE
(2021)
Review
Clinical Neurology
Chenyuan Qin, Jiawei Hu, Yiming Wan, Mengyao Cai, Zhenting Wang, Zhao Peng, Yuxiao Liao, Dan Li, Ping Yao, Liegang Liu, Shuang Rong, Wei Bao, Guifeng Xu, Wei Yang
Summary: This review primarily focuses on the relationships between alcohol, cocaine, and methamphetamine addiction and gut microbiota, as well as possible treatment methods. By establishing a bridge between substance addiction and gut microbiota based on existing evidence, the review aims to explore the potential bidirectional function of the microbiota-gut-brain axis in substance addiction for the development of therapeutic strategies in the future.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)