Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis

Interleukin 27 (IL-27) Alleviates Bone Loss in Estrogen-deficient Conditions by Induction of Early Growth Response-2 Gene

(2017) Priyanka Shukla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrine suppresses airway inflammation by downregulating SOCS3 expression via inhibition of NF-κB signaling in airway epithelial cells and asthmatic mice

(2016) Daqing Sun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Differentiation therapy of hepatocellular carcinoma by inhibiting the activity of AKT/GSK-3β/β-catenin axis and TGF-β induced EMT with sophocarpine

(2016) Ping-Ping Zhang et al.   CANCER LETTERS

Opioid receptor agonists may favorably affect bone mechanical properties in rats with estrogen deficiency-induced osteoporosis

(2016) Aleksandra Janas et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Dihydroartemisinin attenuates lipopolysaccharide-induced osteoclastogenesis and bone loss via the mitochondria-dependent apoptosis pathway

(2016) C Dou et al.   Cell Death & Disease

Management of Postmenopausal Osteoporosis

(2015) Panagiota Andreopoulou et al.   Annual Review of Medicine

Estrogen receptor alpha and beta in health and disease

(2015) Min Jia et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Leonurine hydrochloride inhibits osteoclastogenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-κB and PI3K/Akt signaling pathways

(2015) Feng-Lai Yuan et al.   BONE

Identification of matrine as a promising novel drug for hepatic steatosis and glucose intolerance with HSP72 as an upstream target

(2015) Xiao-Yi Zeng et al.   BRITISH JOURNAL OF PHARMACOLOGY

Epoxyeicosanoids suppress osteoclastogenesis and prevent ovariectomy-induced bone loss

(2015) Hanfeng Guan et al.   FASEB JOURNAL

Inhibition of RANKL-induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium-particle-induced osteolysis

(2015) MINGJUN LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Myelosuppressive Therapies Significantly Increase Pro-Inflammatory Cytokines and Directly Cause Bone Loss

(2015) Julie M Quach et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Correlating RANK Ligand/RANK Binding Kinetics With Osteoclast Formation and Function

(2015) Julia T. Warren et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation des Knochenstoffwechsels bei Osteoporose

(2015) F. Jakob et al.   UNFALLCHIRURG

Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis

(2014) Wei-Heng Xu et al.   HEPATOLOGY

Wnt4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-κB

(2014) Bo Yu et al.   NATURE MEDICINE

Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice

(2014) Eun-Jung Lee et al.   PHYTOMEDICINE

Delphinidin, One of the Major Anthocyanidins, Prevents Bone Loss through the Inhibition of Excessive Osteoclastogenesis in Osteoporosis Model Mice

(2014) Sawako Moriwaki et al.   PLoS One

Biology of the RANKL–RANK–OPG System in Immunity, Bone, and Beyond

(2014) Matthew C. Walsh et al.   Frontiers in Immunology

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB signaling and bone resorption

(2013) Y. Abu-Amer   OSTEOPOROSIS INTERNATIONAL

Matrine effectively inhibits the proliferation of breast cancer cells through a mechanism related to the NF-κB signaling pathway

(2013) HONGMIN SHAO et al.   Oncology Letters

Effects of Estrogen on Vascular Inflammation

(2012) Susana Novella et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Direct protection of neurons and astrocytes by matrine via inhibition of the NF-κB signaling pathway contributes to neuroprotection against focal cerebral ischemia

(2012) Min Xu et al.   BRAIN RESEARCH

Caffeic acid 3,4-dihydroxy-phenethyl ester suppresses receptor activator of NF-κB ligand-induced osteoclastogenesis and prevents ovariectomy-induced bone loss through inhibition of mitogen-activated protein kinase/activator protein 1 and Ca2+-nuclear fact

(2012) Xian Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen Deficiency Induces the Differentiation of IL-17 Secreting Th17 Cells: A New Candidate in the Pathogenesis of Osteoporosis

(2012) Abdul M. Tyagi et al.   PLoS One

Antiinflammatory effects of matrine in LPS-induced acute lung injury in mice

(2011) Bo Zhang et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

New targets for intervention in the treatment of postmenopausal osteoporosis

(2011) E. Michael Lewiecki   Nature Reviews Rheumatology

Bone fractures after menopause

(2010)   HUMAN REPRODUCTION UPDATE

Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways

(2010) Chenghai Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Diphenylhydantoin Inhibits Osteoclast Differentiation and Function Through Suppression of NFATc1 Signaling

(2009) Masanori Koide et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Concentration of adipogenic and proinflammatory cytokines in the bone marrow supernatant fluid of osteoporotic women

(2009) Ana María Pino et al.   JOURNAL OF BONE AND MINERAL RESEARCH

NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism

(2009) Zhenqiang Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Reciprocal roles between caffeine and estrogen on bone via differently regulating cAMP/PKA pathway: The possible mechanism for caffeine-induced osteoporosis in women and estrogen’s antagonistic effects

(2009) Yi Zhou et al.   MEDICAL HYPOTHESES

Osteoclast receptors and signaling

(2008) Andrea Del Fattore et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Estrogen anti-inflammatory activity in brain: A therapeutic opportunity for menopause and neurodegenerative diseases

(2008) Elisabetta Vegeto et al.   FRONTIERS IN NEUROENDOCRINOLOGY