Cannabidiol prevents LPS‐induced microglial inflammation by inhibiting ROS/NF‐κB‐dependent signaling and glucose consumption

Glucose transporter 1 critically controls microglial activation through facilitating glycolysis

(2019) Luxi Wang et al.   Molecular Neurodegeneration

Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

(2019) Cheng-Fang Hsieh et al.   Scientific Reports

Nerve Growth Factor modulates LPS - induced microglial glycolysis and inflammatory responses

(2019) Georgia Fodelianaki et al.   EXPERIMENTAL CELL RESEARCH

Cannabidiol protects livers against nonalcoholic steatohepatitis induced by high‐fat high cholesterol diet via regulating NF‐κB and NLRP3 inflammasome pathway

(2019) Yuanling Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

(2019) Serena Silvestro et al.   MOLECULES

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

(2018) François Mouton-Liger et al.   GLIA

Cannabinoid CB2 receptors in the mouse brain: relevance for Alzheimer’s disease

(2018) Alicia López et al.   Journal of Neuroinflammation

Cannabinoid Delivery Systems for Pain and Inflammation Treatment

(2018) Natascia Bruni et al.   MOLECULES

Cannabidiol Attenuates Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis Through Induction of Myeloid-Derived Suppressor Cells

(2018) David M. Elliott et al.   Frontiers in Immunology

Cannabidiol reduces airway inflammation and fibrosis in experimental allergic asthma

(2018) Francieli Vuolo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine

(2018) Mauricio dos-Santos-Pereira et al.   GLIA

Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells

(2018) Soraya Wilke Saliba et al.   Journal of Neuroinflammation

Neuroprotection by cannabidiol and hypothermia in a piglet model of newborn hypoxic-ischemic brain damage

(2018) Lorena Barata et al.   NEUROPHARMACOLOGY

A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia

(2017) Christin Döring et al.   GLIA

Bioenergetic regulation of microglia

(2017) Soumitra Ghosh et al.   GLIA

Inflammasomes and IL-1 biology in the pathogenesis of allograft dysfunction

(2017) S. Samuel Weigt et al.   JOURNAL OF CLINICAL INVESTIGATION

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responsesin vitro

(2016) Julia E. Sepulveda-Diaz et al.   GLIA

Cannabidiol Limits T Cell-Mediated Chronic Autoimmune Myocarditis: Implications to Autoimmune Disorders and Organ Transplantation

(2016) Wen-Shin Lee et al.   MOLECULAR MEDICINE

Co-administration of cannabidiol and capsazepine reduces L-DOPA-induced dyskinesia in mice: Possible mechanism of action

(2016) Maurício dos-Santos-Pereira et al.   NEUROBIOLOGY OF DISEASE

Cannabidiol, neuroprotection and neuropsychiatric disorders

(2016) Alline C. Campos et al.   PHARMACOLOGICAL RESEARCH

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology

(2016) Alessia Ligresti et al.   PHYSIOLOGICAL REVIEWS

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Are cannabidiol and Δ9-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

(2015) John M McPartland et al.   BRITISH JOURNAL OF PHARMACOLOGY

Unknown

(2015) Enkui Hao et al.   MOLECULAR MEDICINE

Lactate is always the end product of glycolysis

(2015) Matthew J. Rogatzki et al.   Frontiers in Neuroscience

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis sativa

(2014) Alexandre Schier et al.   CNS & Neurological Disorders-Drug Targets

Glucose pathways adaptation supports acquisition of activated microglia phenotype

(2014) J. Gimeno-Bayón et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Evaluation of the insulin releasing and antihyperglycaemic activities of GPR55 lipid agonists using clonal beta-cells, isolated pancreatic islets and mice

(2013) A M McKillop et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin

(2013) Ludmila A. Voloboueva et al.   FEBS LETTERS

Understanding the Molecular Aspects of Tetrahydrocannabinol and Cannabidiol as Antioxidants

(2013) Rosivaldo Borges et al.   MOLECULES

Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors

(2013) M. Mecha et al.   NEUROBIOLOGY OF DISEASE

Direct modulation of the outer mitochondrial membrane channel, voltage-dependent anion channel 1 (VDAC1) by cannabidiol: a novel mechanism for cannabinoid-induced cell death

(2013) N Rimmerman et al.   Cell Death & Disease

Is the cardiovascular system a therapeutic target for cannabidiol?

(2012) Christopher P. Stanley et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Off-Target Cannabinoid Effects Mediated by GPR55

(2012) Christopher M. Henstridge   PHARMACOLOGY

Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice

(2011) Ewa Kozela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer's Disease

(2011) A. M. Martin-Moreno et al.   MOLECULAR PHARMACOLOGY

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ9-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive–compulsive behaviour

(2011) Serena Deiana et al.   PSYCHOPHARMACOLOGY

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis

(2010) Sean D. McAllister et al.   BREAST CANCER RESEARCH AND TREATMENT

CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies

(2010) E. Zurolo et al.   NEUROSCIENCE

Pharmacological characterization of GPR55, a putative cannabinoid receptor

(2010) Haleli Sharir et al.   PHARMACOLOGY & THERAPEUTICS

The CB1 inverse agonist AM251, but not the CB1 antagonist AM4113, enhances retention of contextual fear conditioning in rats

(2010) K.S. Sink et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells

(2009) Ewa Kozela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2+ Levels

(2009) D. Ryan et al.   JOURNAL OF NEUROSCIENCE

Inhibitory actions of bilberry anthocyanidins on angiogenesis

(2009) Nozomu Matsunaga et al.   PHYTOTHERAPY RESEARCH

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Apocynin: Molecular Aptitudes

(2008) J. Stefanska et al.   MEDIATORS OF INFLAMMATION

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY