Microglial glutamate release evoked by α-synuclein aggregates is prevented by dopamine

Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop

(2018) François Mouton-Liger et al.   GLIA

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

(2018) Liyan Hou et al.   Redox Biology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Modulation of the extent of structural heterogeneity in α-synuclein fibrils by the small molecule thioflavin T

(2017) Harish Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons

(2017) Jérémie Lavaur et al.   JOURNAL OF NEUROCHEMISTRY

Physico-Pathologic Mechanisms Involved in Neurodegeneration: Misfolded Protein-Plasma Membrane Interactions

(2017) Amulya Nidhi Shrivastava et al.   NEURON

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis

(2017) Papa Alioune Ndour et al.   Science Translational Medicine

Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff

(2017) Heiko Braak et al.   Journal of Parkinsons Disease

Autophagy down regulates pro-inflammatory mediators in BV2 microglial cells and rescues both LPS and alpha-synuclein induced neuronal cell death

(2017) Claudio Bussi et al.   Scientific Reports

Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species

(2017) Florencia González-Lizárraga et al.   Scientific Reports

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

(2016) Alana Hoffmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A simplified approach for efficient isolation of functional microglial cells: Application for modeling neuroinflammatory responsesin vitro

(2016) Julia E. Sepulveda-Diaz et al.   GLIA

Cystine/glutamate antiporter blockage induces myelin degeneration

(2016) Federico N. Soria et al.   GLIA

Glia and alpha-synuclein in neurodegeneration: A complex interaction

(2016) Dominik Brück et al.   NEUROBIOLOGY OF DISEASE

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways

(2016) Flávia V. Santa-Cecília et al.   NEUROTOXICITY RESEARCH

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Amyloid fibrils are the molecular trigger of inflammation in Parkinson's disease

(2015) A. Gustot et al.   BIOCHEMICAL JOURNAL

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

A53T Human  -Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration

(2015) L. Chen et al.   JOURNAL OF NEUROSCIENCE

P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation

(2015) Tianfang Jiang et al.   NEUROBIOLOGY OF AGING

Pathogenic Mechanisms of Neurodegeneration in Parkinson Disease

(2015) Stephen Mullin et al.   NEUROLOGIC CLINICS

α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

(2015) Shijun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion-like propagation of human brain-derived alpha-synuclein in transgenic mice expressing human wild-type alpha-synuclein

(2015) Maria E. Bernis et al.   Acta Neuropathologica Communications

Long Withdrawal of Methylphenidate Induces a Differential Response of the Dopaminergic System and Increases Sensitivity to Cocaine in the Prefrontal Cortex of Spontaneously Hypertensive Rats

(2015) Maurício dos Santos Pereira et al.   PLoS One

System xC− is a mediator of microglial function and its deletion slows symptoms in amyotrophic lateral sclerosis mice

(2014) Pinar Mesci et al.   BRAIN

Implications of non-canonical G-protein signaling for the immune system

(2014) Cédric Boularan et al.   CELLULAR SIGNALLING

Pathological Role for Exocytotic Glutamate Release from Astrocytes in Hepatic Encephalopathy

(2014) Vedrana Montana et al.   Current Neuropharmacology

Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson's disease

(2014) Anke A. Dijkstra et al.   MOVEMENT DISORDERS

The NADPH oxidase Nox2 regulates VEGFR1/CSF-1R-mediated microglial chemotaxis and promotes early postnatal infiltration of phagocytes in the subventricular zone of the mouse cerebral cortex

(2013) Aurélia Lelli et al.   GLIA

A further update on the role of excitotoxicity in the pathogenesis of Parkinson’s disease

(2013) Giulia Ambrosi et al.   JOURNAL OF NEURAL TRANSMISSION

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists

(2013) Michael A. Letavic et al.   ACS Medicinal Chemistry Letters

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

Microglial Activation and Antioxidant Responses Induced by the Parkinson’s Disease Protein α-Synuclein

(2012) Dawn Béraud et al.   Journal of Neuroimmune Pharmacology

Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link?

(2012) Carla M. Lema Tomé et al.   MOLECULAR NEUROBIOLOGY

Inhibition of transporter-mediated cystine uptake by sulfasalazine analogs

(2011) Krupa Shukla et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TLR2 Ligand Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of Phosphoinositide 3-Kinase/Akt Signaling

(2011) C. Lu et al.   JOURNAL OF IMMUNOLOGY

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Assessment of α-Synuclein Secretion in Mouse and Human Brain Parenchyma

(2011) Evangelia Emmanouilidou et al.   PLoS One

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms

(2009) Maria C Rodriguez-Oroz et al.   LANCET NEUROLOGY

Neuroinflammation in the living brain of Parkinson's disease

(2009) Yasuomi Ouchi et al.   PARKINSONISM & RELATED DISORDERS

[11C]-PK11195 PET: Quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?

(2009) A.L. Bartels et al.   PARKINSONISM & RELATED DISORDERS

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

Regulation of glutathione synthesis

(2008) Shelly C. Lu   MOLECULAR ASPECTS OF MEDICINE

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS