Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

Highly electronegative low-density lipoprotein L5 evokes microglial activation and creates a neuroinflammatory stress via Toll-like receptor 4 signaling

(2017) Liang-En Yu et al.   JOURNAL OF NEUROCHEMISTRY

Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition

(2017) Marina Bogush et al.   Journal of Neuroimmune Pharmacology

Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice

(2016) Montasir Elahi et al.   JOURNAL OF ALZHEIMERS DISEASE

Breakdown of the Cerebrovasculature and Blood-Brain Barrier: A Mechanistic Link Between Diabetes Mellitus and Alzheimer’s Disease

(2016) Eric L. Goldwaser et al.   JOURNAL OF ALZHEIMERS DISEASE

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

(2016) Mak Adam Daulatzai   JOURNAL OF NEUROSCIENCE RESEARCH

Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches

(2016) Mi Park et al.   Cells

Diabetes Mellitus and Dementia

(2014) Toshiharu Ninomiya   Current Diabetes Reports

GLUT2, glucose sensing and glucose homeostasis

(2014) Bernard Thorens   DIABETOLOGIA

Astrocytic and microglial response in experimentally induced diabetic rat brain

(2014) Aarti Nagayach et al.   METABOLIC BRAIN DISEASE

Activation of microglia and induction of pro-inflammatory cytokines in the hippocampus of type 2 diabetic rats

(2014) In Koo Hwang et al.   NEUROLOGICAL RESEARCH

Nitric oxide plays a dual role in the oxidative injury of cultured rat microglia but not astroglia

(2014) J.-Y. Wang et al.   NEUROSCIENCE

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

(2014) María Muriach et al.   Oxidative Medicine and Cellular Longevity

Multi-Scale Glycemic Variability: A Link to Gray Matter Atrophy and Cognitive Decline in Type 2 Diabetes

(2014) Xingran Cui et al.   PLoS One

p38 and JNK MAPK pathways control the balance of apoptosis and autophagy in response to chemotherapeutic agents

(2013) Xinbing Sui et al.   CANCER LETTERS

Site-specific activation of AKT protects cells from death induced by glucose deprivation

(2013) M Gao et al.   ONCOGENE

Targeting disease through novel pathways of apoptosis and autophagy

(2012) Kenneth Maiese et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis

(2012) Simon M. Schultze et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol

(2012) Lanyu Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Heme Oxygenase-1 Protects Retinal Endothelial Cells against High Glucose- and Oxidative/Nitrosative Stress-Induced Toxicity

(2012) Áurea F. Castilho et al.   PLoS One

Cognitive impairment in diabetic patients: Can diabetic control prevent cognitive decline?

(2012) Takahiko Kawamura et al.   Journal of Diabetes Investigation

Regulation of Autophagy by Glucose in Mammalian Cells

(2012) Félix Moruno et al.   Cells

Oxidative Stress and Diabetic Complications

(2010) Ferdinando Giacco et al.   CIRCULATION RESEARCH

Relationships Between Daily Acute Glucose Fluctuations and Cognitive Performance Among Aged Type 2 Diabetic Patients

(2010) M. R. Rizzo et al.   DIABETES CARE

MAPK signalling in cellular metabolism: stress or wellness?

(2010) Helmuth Gehart et al.   EMBO REPORTS

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Heat stress upregulates chaperone heat shock protein 70 and antioxidant manganese superoxide dismutase through reactive oxygen species (ROS), p38MAPK, and Akt

(2009) Soumyajit Banerjee Mustafi et al.   CELL STRESS & CHAPERONES

The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning

(2009) Nuria Lafuente et al.   JOURNAL OF HYPERTENSION

Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

(2008) Ying Liu et al.   FEBS LETTERS

The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders

(2008) Berislav V. Zlokovic   NEURON

Nutrient deprivation induces autophagy as well as apoptosis in Chinese hamster ovary cell culture

(2007) Sun Ok Hwang et al.   BIOTECHNOLOGY AND BIOENGINEERING