Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies

The Maintenance of Memory Plasma Cells

(2019) Laleh Khodadadi et al.   Frontiers in Immunology

CXCR4-CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice

(2018) Qingyu Cheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors

(2018) Tobias Alexander et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antibody-secreting plasma cells persist for decades in human intestine

(2017) Ole J.B. Landsverk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTOR has distinct functions in generating versus sustaining humoral immunity

(2016) Derek D. Jones et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma cells as an innovative target in autoimmune disease with renal manifestations

(2016) Falk Hiepe et al.   Nature Reviews Nephrology

Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis

(2016) Franziska Scheibe et al.   NEUROLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

(2015) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

The development of potential antibody-based therapies for myeloma

(2015) Daniel W. Sherbenou et al.   BLOOD REVIEWS

Targeting CD38 with Daratumumab Monotherapy in Multiple Myeloma

(2015) Henk M. Lokhorst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

(2015) Adriano Taddeo et al.   ARTHRITIS RESEARCH & THERAPY

Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice

(2015) Laleh Khodadadi et al.   PLoS One

Review of Bortezomib Treatment of Antibody-Mediated Rejection in Renal Transplantation

(2014) Nicole S. Ejaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Selection and depletion of plasma cells based on the specificity of the secreted antibody

(2014) Adriano Taddeo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells

(2014) Sandra Zehentmeier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis

(2013) Qingyu Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

(2013) Matthew S. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

(2012) Imtiaz M. Mumtaz et al.   JOURNAL OF AUTOIMMUNITY

Neonatal Fc Receptor Blockade by Fc Engineering Ameliorates Arthritis in a Murine Model

(2011) D. A. Patel et al.   JOURNAL OF IMMUNOLOGY

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Selective Cytotoxicity Against CD138-Positive Multiple Myeloma Cells In vitro and In vivo

(2009) H. Ikeda et al.   CLINICAL CANCER RESEARCH

Induction of long-lived allergen-specific plasma cells by mucosal allergen challenge

(2009) Elke O. Luger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases

(2009) Glinda S. Cooper et al.   JOURNAL OF AUTOIMMUNITY

The third dimension of ELISPOTs: Quantifying antibody secretion from individual plasma cells

(2009) Erin Bromage et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

(2008) T. Alexander et al.   BLOOD

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE