Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

(2015) Tobias Alexander et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

(2015) Adriano Taddeo et al.   ARTHRITIS RESEARCH & THERAPY

Long-Term B Cell Depletion in Murine Lupus Eliminates Autoantibody-Secreting Cells and Is Associated with Alterations in the Kidney Plasma Cell Niche

(2014) W. Wang et al.   JOURNAL OF IMMUNOLOGY

The BAFF/APRIL system in SLE pathogenesis

(2014) Fabien B. Vincent et al.   Nature Reviews Rheumatology

Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis

(2013) Qingyu Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

(2012) Imtiaz M. Mumtaz et al.   JOURNAL OF AUTOIMMUNITY

B cell biomarkers of rituximab responses in systemic lupus erythematosus

(2011) Edward M. Vital et al.   ARTHRITIS AND RHEUMATISM

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus

(2010) Andrew Wang et al.   ARTHRITIS AND RHEUMATISM

Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus

(2010) Kai W. Bekar et al.   ARTHRITIS AND RHEUMATISM

Protective and Pathogenic Roles for B Cells during Systemic Autoimmunity in NZB/W F1 Mice

(2010) K. M. Haas et al.   JOURNAL OF IMMUNOLOGY

Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis

(2010) H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HLA-DRhigh/CD27high plasmablasts indicate active disease in patients with systemic lupus erythematosus

(2009) A M Jacobi et al.   ANNALS OF THE RHEUMATIC DISEASES

Bortezomib-induced peripheral neuropathy in multiple myeloma: A comparison between previously treated and untreated patients

(2009) Alessandro Corso et al.   LEUKEMIA RESEARCH

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

(2008) T. Alexander et al.   BLOOD

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Maintenance of the plasma cell pool is independent of memory B cells

(2008) A. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA