Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a combined targeting of autoreactive plasma cells and their precursors

Response to letter by Aramugakaniet al

(2014) Gianfranco Ferraccioli et al.   ANNALS OF THE RHEUMATIC DISEASES

A3.26 Proteasome inhibition with bortezomib in refractory SLE inhibits type I interferon and depletes plasma cells but does not inhibit their regeneration

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Response to: ‘Which B-cell subset should we target in lupus?’ by Ferraccioli and Houssiau

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Cutting Edge: The Dependence of Plasma Cells and Independence of Memory B Cells on BAFF and APRIL

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Long-Term B Cell Depletion in Murine Lupus Eliminates Autoantibody-Secreting Cells and Is Associated with Alterations in the Kidney Plasma Cell Niche

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Which B-cell subset should we target in lupus?

(2013) Gianfranco Ferraccioli et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies from long-lived ‘memory’ plasma cells of NZB/W mice drive immune complex nephritis

(2013) Qingyu Cheng et al.   ANNALS OF THE RHEUMATIC DISEASES

Lymphocytopenia is associated with an increased risk of severe infections in patients with multiple myeloma treated with bortezomib-based regimens

(2013) Sung-Hoon Jung et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Disease Control and Safety of Belimumab Plus Standard Therapy Over 7 Years in Patients with Systemic Lupus Erythematosus

(2013) E. M. Ginzler et al.   JOURNAL OF RHEUMATOLOGY

Long-Lived Plasma Cells in Autoimmunity: Lessons from B-Cell Depleting Therapy

(2013) Matthieu Mahévas et al.   Frontiers in Immunology

Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus

(2012) William Stohl et al.   ARTHRITIS AND RHEUMATISM

Bone marrow of NZB/W mice is the major site for plasma cells resistant to dexamethasone and cyclophosphamide: Implications for the treatment of autoimmunity

(2012) Imtiaz M. Mumtaz et al.   JOURNAL OF AUTOIMMUNITY

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

High frequency of autoantibody-secreting cells and long-lived plasma cells within inflamed kidneys of NZB/W F1 lupus mice

(2011) Charlotte Starke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Prolonged effects of short-term anti-CD20 B cell depletion therapy in murine systemic lupus erythematosus

(2010) Kai W. Bekar et al.   ARTHRITIS AND RHEUMATISM

A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus

(2009) Daniel J. Wallace et al.   ARTHRITIS AND RHEUMATISM

Effect of long-term belimumab treatment on b cells in systemic lupus erythematosus: Extension of a phase II, double-blind, placebo-controlled, dose-ranging study

(2009) Annett M. Jacobi et al.   ARTHRITIS AND RHEUMATISM

Bortezomib-induced peripheral neuropathy in multiple myeloma: A comparison between previously treated and untreated patients

(2009) Alessandro Corso et al.   LEUKEMIA RESEARCH

Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system

(2008) T. Alexander et al.   BLOOD

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

Systemic Lupus Erythematosus

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