Heat shock proteins in the physiology and pathophysiology of epidermal keratinocytes

Photobiomodulation Therapy for Wound Care

(2019) Rodrigo Crespo Mosca et al.   Advances in Skin & Wound Care

Topical heat shock protein 70 prevents imiquimod-induced psoriasis-like inflammation in mice

(2018) Federico G. Seifarth et al.   CELL STRESS & CHAPERONES

Extracellular and Non-Chaperone Function of Heat Shock Protein−90α Is Required for Skin Wound Healing

(2018) Ayesha Bhatia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Orchestrated control of filaggrin–actin scaffolds underpins cornification

(2018) Danuta Gutowska-Owsiak et al.   Cell Death & Disease

The role of secreted heat shock protein-90 (Hsp90) in wound healing - how could it shape future therapeutics?

(2017) Jiacong Guo et al.   Expert Review of Proteomics

Novel role for the testis-enriched HSPA2 protein in regulating epidermal keratinocyte differentiation

(2017) Agnieszka Gogler-Pigłowska et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A Role for DLK in Microtubule Reorganization to the Cell Periphery and in the Maintenance of Desmosomal and Tight Junction Integrity

(2017) Carolyne Simard-Bisson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands?

(2017) Stuart K. Calderwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Defective glucocorticoid receptor signaling and keratinocyte-autonomous defects contribute to skin phenotype of mouse embryos lacking the Hsp90 co-chaperone p23

(2017) Marta Madon-Simon et al.   PLoS One

Treatment of Ischemia-Reperfusion Injury of the Skin Flap Using Human Umbilical Cord Mesenchymal Stem Cells (hUC-MSCs) Transfected with “F-5” Gene

(2017) Xiangfeng Leng et al.   MEDICAL SCIENCE MONITOR

Heat Shock Protein 27 kDa Content in Stratum Corneum Correlates with Severity of Atopic Dermatitis

(2016) S Niiyama et al.   ACTA DERMATO-VENEREOLOGICA

Wound healing - A literature review

(2016) Ana Cristina de Oliveira Gonzalez et al.   ANAIS BRASILEIROS DE DERMATOLOGIA

Fate by Chance, not by Choice: Epidermal Stem Cells Go Live

(2016) Meryem Gonzalez-Celeiro et al.   Cell Stem Cell

The human HSP70 family of chaperones: where do we stand?

(2016) Jürgen Radons   CELL STRESS & CHAPERONES

The Future of Fractional Lasers

(2016) Uwe Paasch   FACIAL PLASTIC SURGERY

Variation in Hsp70-1A Expression Contributes to Skin Color Diversity

(2016) Daiki Murase et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression

(2016) M Zou et al.   ONCOGENE

Global gene expression and comparison between multiple populations in the mouse epidermis

(2016) Anders Patrik Gunnarsson et al.   Stem Cell Research

Cellular mechanisms of skin repair in humans and other mammals

(2016) Laure Rittié   Journal of Cell Communication and Signaling

Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs

(2016) Ayesha Bhatia et al.   Molecular Therapy-Methods & Clinical Development

Expression of Heat Shock Protein 70 in Human Skin Cells as a Photoprotective Function after UV Exposure

(2016) Byoung Hwa Roh et al.   Annals of Dermatology

Cell type-dependent modulation of the gene encoding heat shock protein HSPA2 by hypoxia-inducible factor HIF-1: Down-regulation in keratinocytes and up-regulation in HeLa cells

(2015) Anna Habryka et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Heat shock protein 90: a pathophysiological factor and novel treatment target in autoimmune bullous skin diseases

(2015) Stefan Tukaj et al.   EXPERIMENTAL DERMATOLOGY

Regulation and function of the human HSP90AA1 gene

(2015) Abbey D. Zuehlke et al.   GENE

In Vivo Suppression of Heat Shock Protein (HSP)27 and HSP70 Accelerates DMBA-Induced Skin Carcinogenesis by Inducing Antigenic Unresponsiveness to the Initiating Carcinogenic Chemical

(2015) Nabiha Yusuf et al.   JOURNAL OF IMMUNOLOGY

Topically Applied Hsp90 Inhibitor 17AAG Inhibits UVR-Induced Cutaneous Squamous Cell Carcinomas

(2015) Anupama Singh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Heat-shock pretreatment reduces expression and release of TSLP from keratinocytes under Th2 environment

(2015) Jun-Kai Kao et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Hsp90 interaction with clients

(2015) G. Elif Karagöz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing

(2015) David T. Woodley et al.   Advances in Wound Care

Extracellular cell stress proteins as biomarkers of human disease

(2014) A. Graham Pockley et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Hsp90 blockade modulates bullous pemphigoid IgG-induced IL-8 production by keratinocytes

(2014) Stefan Tukaj et al.   CELL STRESS & CHAPERONES

Expression, function, and regulation of the testis-enriched heat shock HSPA2 gene in rodents and humans

(2014) Dorota Scieglinska et al.   CELL STRESS & CHAPERONES

Basal and stress-inducible expression of HSPA6 in human keratinocytes is regulated by negative and positive promoter regions

(2014) Vincent P. Ramirez et al.   CELL STRESS & CHAPERONES

Small heat-shock proteins: important players in regulating cellular proteostasis

(2014) Teresa M. Treweek et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heat Shock Proteins as Prognostic Markers of Cancer

(2014) Evgeniya Kaigorodova et al.   CURRENT CANCER DRUG TARGETS

Low-level laser irradiation promotes the proliferation and maturation of keratinocytes during epithelial wound repair

(2014) Felipe F. Sperandio et al.   Journal of Biophotonics

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

(2014) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Increased expression of heat shock protein 90 in keratinocytes and mast cells in patients with psoriasis

(2014) Masato Kakeda et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Role for Heat Shock Protein 90α in the Proliferation and Migration of HaCaT Cells and in the Deep Second-Degree Burn Wound Healing in Mice

(2014) Yue Zhang et al.   PLoS One

Identification of the Critical Therapeutic Entity in Secreted Hsp90α That Promotes Wound Healing in Newly Re-Standardized Healthy and Diabetic Pig Models

(2014) Kathryn O'Brien et al.   PLoS One

HSP27 as a biomarker for predicting skin irritation in human skin and reconstructed organotypic skin model

(2014) Hongxia Chen et al.   TOXICOLOGY LETTERS

Lineage Analysis of Epidermal Stem Cells

(2014) M. P. Alcolea et al.   Cold Spring Harbor Perspectives in Medicine

Sunlight UV-Induced Skin Cancer Relies upon Activation of the p38  Signaling Pathway

(2013) K. Liu et al.   CANCER RESEARCH

Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1pathways

(2013) Maria Zamkova et al.   CELL CYCLE

Human small heat shock proteins: Protein interactomes of homo- and hetero-oligomeric complexes: An update

(2013) André-Patrick Arrigo   FEBS LETTERS

UV Radiation and the Skin

(2013) John D'Orazio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Expression of heat shock proteins 70 and 47 in tissues following short-pulse laser irradiation: Assessment of thermal damage and healing

(2013) Amir Yousef Sajjadi et al.   MEDICAL ENGINEERING & PHYSICS

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

(2013) F. Tsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein extract of ultraviolet-irradiated human skin keratinocytes promote the expression of mitogen-activated protein kinases, nuclear factor-κB and interferon regulatory factor-3 in Langerhans cells via Toll-like receptor 2 and 4

(2013) Xiao-Yong Wang et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Aberrant Expression and Secretion of Heat Shock Protein 90 in Patients with Bullous Pemphigoid

(2013) Stefan Tukaj et al.   PLoS One

Heat Shock Protein B1-Deficient Mice Display Impaired Wound Healing

(2013) Jonathan Crowe et al.   PLoS One

The chaperone Hsp90: changing partners for demanding clients

(2013) Alina Röhl et al.   TRENDS IN BIOCHEMICAL SCIENCES

Epidermal Stem Cells in Homeostasis and Wound Repair of the Skin

(2013) Makoto Senoo   Advances in Wound Care

Temporal Gene Expression Kinetics for Human Keratinocytes Exposed to Hyperthermic Stress

(2013) Ibtissam Echchgadda et al.   Cells

HSPA2 overexpression protects V79 fibroblasts against bortezomib-induced apoptosis

(2012) Piotr Teodor Filipczak et al.   Biochemistry and Cell Biology

The Therapeutic Target Hsp90 and Cancer Hallmarks

(2012) Yoshihiko Miyata et al.   CURRENT PHARMACEUTICAL DESIGN

Interfollicular epidermal homeostasis: dicing with differentiation

(2012) David P. Doupé et al.   EXPERIMENTAL DERMATOLOGY

HSPBs: Small proteins with big implications in human disease

(2012) Harm H. Kampinga et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Absence of a Human DnaJ Protein hTid-1SCorrelates with Aberrant Actin Cytoskeleton Organization in Lesional Psoriatic Skin

(2012) Ji Hye Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo analysis of laser preconditioning in incisional wound healing of wild-type and HSP70 knockout mice with Raman spectroscopy

(2012) Alexander J. Makowski et al.   LASERS IN SURGERY AND MEDICINE

Hyperthermia-induced micronucleus formation in a human keratinocyte cell line

(2012) Henning Hintzsche et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Distinct contribution of stem and progenitor cells to epidermal maintenance

(2012) Guilhem Mascré et al.   NATURE

Alkannin, HSP70 Inducer, Protects against UVB-Induced Apoptosis in Human Keratinocytes

(2012) Yoko Yoshihisa et al.   PLoS One

Effects of UVB-induced oxidative stress on protein expression and specific protein oxidation in normal human epithelial keratinocytes: a proteomic approach

(2012) Marzia Perluigi et al.   Proteome Science

The Hsp90 inhibitor 17-AAG represses calcium-induced cytokeratin 1 and 10 expression in HaCaT keratinocytes

(2012) Sadanori Miyoshi et al.   FEBS Open Bio

The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities

(2011) Jurre Hageman et al.   BIOCHEMICAL JOURNAL

Human keratinocytes release high levels of inducible heat shock protein 70 that enhances peptide uptake

(2011) Dong Wang et al.   EXPERIMENTAL DERMATOLOGY

Differential expression of HSPA1 and HSPA2 proteins in human tissues; tissue microarray-based immunohistochemical study

(2011) Dorota Scieglinska et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis

(2011) Qihao Zhang et al.   JOURNAL OF APPLIED TOXICOLOGY

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

(2011) Chieh-Fang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular changes during skin aging and wound healing after fractional ablative photothermolysis

(2011) Doris Helbig et al.   SKIN RESEARCH AND TECHNOLOGY

Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

(2011) Adrienne T. Black et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus

(2010) B. G. Furnrohr et al.   ANNALS OF THE RHEUMATIC DISEASES

Sodium fluoride influences the expression of keratins in cultured keratinocytes

(2010) Euridice Prado et al.   CELL BIOLOGY AND TOXICOLOGY

Heteromeric complexes of heat shock protein 70 (HSP70) family members, including Hsp70B′, in differentiated human neuronal cells

(2010) Ari M. Chow et al.   CELL STRESS & CHAPERONES

Distinguishing integral and receptor-bound heat shock protein 70 (Hsp70) on the cell surface by Hsp70-specific antibodies

(2010) Gabriele Multhoff et al.   CELL STRESS & CHAPERONES

Standardized tape stripping prior to patch testing induces upregulation of Hsp90, Hsp70, IL-33, TNF-α and IL-8/CXCL8 mRNA: new insights into the involvement of ‘alarmins’

(2010) Heinrich Dickel et al.   CONTACT DERMATITIS

Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell lines

(2010) Yoshitaka Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The hsp27kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation

(2010) Constanze Jonak et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Ezrin, Maspin, Peroxiredoxin 2, and Heat Shock Protein 27: Potential Targets of a Streptococcal-Induced Autoimmune Response in Psoriasis

(2010) P. Besgen et al.   JOURNAL OF IMMUNOLOGY

Heavy metals chromium and neodymium reduced phosphorylation level of heat shock protein 27 in human keratinocytes

(2010) Qihao Zhang et al.   TOXICOLOGY IN VITRO

Evaluation of the Skin Irritation Using a DNA Microarray on a Reconstructed Human Epidermal Model

(2009) Makoto Niwa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The topical antimicrobial zinc pyrithione is a heat shock response inducer that causes DNA damage and PARP-dependent energy crisis in human skin cells

(2009) Sarah D. Lamore et al.   CELL STRESS & CHAPERONES

The expression pattern of the 70-kDa heat shock protein Hspa2 in mouse tissues

(2009) Natalia Vydra et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Prevention of UVB Radiation-induced Epidermal Damage by Expression of Heat Shock Protein 70

(2009) Minoru Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90  autocrine signaling to promote keratinocyte migration

(2009) D. T. Woodley et al.   JOURNAL OF CELL SCIENCE

Prevention of the ultraviolet effects on clinical and histopathological changes, as well as the heat shock protein-70 expression in mouse skin by topical application of algal UV-absorbing compounds

(2009) F. de la Coba et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Small Heat-Shock Protein Hsp27 Undergoes ERK-Dependent Phosphorylation and Redistribution to the Cytoskeleton in Response to Dual Leucine Zipper-Bearing Kinase Expression

(2009) Hubert Robitaille et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

HSP70 and EndoG Modulate Cell Death by Heat in Human Skin Keratinocytes in vitro

(2008) Sathivel Chinnathambi et al.   CELLS TISSUES ORGANS

Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia

(2008) Wen-Jie Huang et al.   INTERNATIONAL JOURNAL OF CANCER

In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin

(2008) Gerald J. Wilmink et al.   JOURNAL OF BIOMEDICAL OPTICS

Transforming Growth Factor   (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing

(2008) C.-F. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Tiers of Clonal Organization in the Epidermis: The Epidermal Proliferation Unit Revisited

(2008) Lauren R. Strachan et al.   Stem Cell Reviews and Reports

Proteomic assessment of sulfur mustard-induced protein adducts and other protein modifications in human epidermal keratinocytes

(2008) Marijke A.E. Mol et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Hsp27 Regulates Pro-Inflammatory Mediator Release in Keratinocytes by Modulating NF-κB Signaling

(2007) Runa Sur et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY