Evolutionarily conserved dual lysine motif determines the non-chaperone function of secreted Hsp90alpha in tumour progression

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment

(2016) Hangming Dong et al.   Scientific Reports

Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

(2015) Charan V. Devarakonda et al.   BMC CANCER

Tumor-secreted Hsp90 Subverts Polycomb Function to Drive Prostate Tumor Growth and Invasion

(2015) Krystal D. Nolan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Levels of Heat Shock Protein 90 Alpha Associated with Lung Cancer Development and Treatment Responses

(2014) Y. Shi et al.   CLINICAL CANCER RESEARCH

An Impermeant Ganetespib Analog Inhibits Extracellular Hsp90-Mediated Cancer Cell Migration that Involves Lysyl Oxidase 2-like Protein

(2014) Jessica McCready et al.   Cancers

Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis

(2013) R. Liu et al.   CLINICAL CANCER RESEARCH

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

(2013) F. Tsen et al.   MOLECULAR AND CELLULAR BIOLOGY

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response

(2013) D. Tseng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?

(2012) L. Neckers et al.   CLINICAL CANCER RESEARCH

Cell Surface Cdc37 Participates in Extracellular HSP90 Mediated Cancer Cell Invasion

(2012) Avraam El Hamidieh et al.   PLoS One

Secreted heat shock protein-90 (Hsp90) in wound healing and cancer

(2011) Wei Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice

(2011) Chieh-Fang Cheng et al.   JOURNAL OF CLINICAL INVESTIGATION

A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

(2011) Divya Sahu et al.   MOLECULAR BIOLOGY OF THE CELL

The Molecular Chaperone Hsp90α Is Required for Meiotic Progression of Spermatocytes beyond Pachytene in the Mouse

(2011) Iwona Grad et al.   PLoS One

Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells

(2011) T. Imai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretion of extracellular hsp90α via exosomes increases cancer cell motility: a role for plasminogen activation

(2010) Jessica McCready et al.   BMC CANCER

Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

(2010) Dimitris Stellas et al.   BMC CELL BIOLOGY

Secreted Heat Shock Protein 90α Induces Colorectal Cancer Cell Invasion through CD91/LRP-1 and NF-κB-mediated Integrin αVExpression

(2010) Jinn-Shiun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies

(2010) X Ye et al.   ONCOGENE

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

(2009) Xiaofeng Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor   (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing

(2008) C.-F. Cheng et al.   MOLECULAR AND CELLULAR BIOLOGY