期刊
CANCER BIOLOGY & THERAPY
卷 10, 期 11, 页码 1195-1201出版社
LANDES BIOSCIENCE
DOI: 10.4161/cbt.10.11.13814
关键词
pten; shRNA; RNAi; neoplasia; haploinsufficiency; tumor suppressor
类别
资金
- NCI [CA082783]
To address the impact of partial reduction of Pten on tumor initiation, we generated Pten(shRNA) mice, in which PTEN expression was reduced below normal levels in various tissues. Pten(shRNA) mice frequently developed lymphoid and prostatic hyperplasia, splenomegaly and sebaceous adenomas. Our observations support the notion that partial reduction of the dose of Pten with shRNA is sufficient to induce neoplastic disease in multiple organ systems.
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