The functions and regulation of the PTEN tumour suppressor: new modes and prospects

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation

(2017) Amit Gupta et al.   MOLECULAR CELL

Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer

(2017) Di Zhao et al.   NATURE

mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer

(2017) Amaia Zabala-Letona et al.   NATURE

PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition

(2017) Deepti Mathur et al.   Cancer Discovery

Identification of competing endogenous RNAs of the tumor suppressor gene PTEN: A probabilistic approach

(2017) Kourosh Zarringhalam et al.   Scientific Reports

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells

(2016) Xiaolin Luo et al.   Cell Reports

Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy

(2016) Sarah A. Altınoğlu et al.   Biomaterials Science

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity

(2015) G. R. Masson et al.   BIOCHEMICAL JOURNAL

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

(2015) Lin Zhang et al.   NATURE

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

(2015) Lin Yuan et al.   NATURE CELL BIOLOGY

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals

(2015) Helen He Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PTEN Tumor Suppressor Forms Homodimers in Solution

(2015) Frank Heinrich et al.   STRUCTURE

Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function

(2014) Antonella Papa et al.   CELL

PTENα, a PTEN Isoform Translated through Alternative Initiation, Regulates Mitochondrial Function and Energy Metabolism

(2014) Hui Liang et al.   Cell Metabolism

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

(2014) Wei-Chien Yuan et al.   MOLECULAR CELL

PTEN action in leukaemia dictated by the tissue microenvironment

(2014) Cornelius Miething et al.   NATURE

Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer

(2014) Diletta Di Mitri et al.   NATURE

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PTEN is a protein tyrosine phosphatase for IRS1

(2014) Yuji Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities

(2014) Hoai-Nghia Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

(2014) Shingo Nakahata et al.   Nature Communications

Characterization of Dual PTEN and p53-Targeting MicroRNAs Identifies MicroRNA-638/Dnm2 as a Two-Hit Oncogenic Locus

(2014) Yvonne Tay et al.   Cell Reports

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN

(2013) S-W Hong et al.   CELL DEATH AND DIFFERENTIATION

MC1R Is a Potent Regulator of PTEN after UV Exposure in Melanocytes

(2013) Juxiang Cao et al.   MOLECULAR CELL

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

(2013) Jan R. Dörr et al.   NATURE

Deubiquitylation and stabilization of PTEN by USP13

(2013) Jinsong Zhang et al.   NATURE CELL BIOLOGY

A Secreted PTEN Phosphatase That Enters Cells to Alter Signaling and Survival

(2013) B. D. Hopkins et al.   SCIENCE

Nuclear PTEN Controls DNA Repair and Sensitivity to Genotoxic Stress

(2013) C. Bassi et al.   SCIENCE

Novel Mechanism of Tumor Suppression by Polarity Gene Discs Large 1 (DLG1) Revealed in a Murine Model of Pediatric B-ALL

(2013) G. J. Sandoval et al.   Cancer Immunology Research

Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Functional analysis of the protein phosphatase activity of PTEN

(2012) Xiaoqun Catherine Zhang et al.   BIOCHEMICAL JOURNAL

Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State

(2012) Isabel Garcia-Cao et al.   CELL

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

mTOR Complex 1 Plays Critical Roles in Hematopoiesis and Pten-Loss-Evoked Leukemogenesis

(2012) Demetrios Kalaitzidis et al.   Cell Stem Cell

The Chaperone-assisted E3 Ligase C Terminus of Hsc70-interacting Protein (CHIP) Targets PTEN for Proteasomal Degradation

(2012) Syed Feroj Ahmed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

(2012) Jason Howitt et al.   JOURNAL OF CELL BIOLOGY

The mitogen-activated protein kinase (MAPK) cascade controls phosphatase and tensin homolog (PTEN) expression through multiple mechanisms

(2012) Ludovica Ciuffreda et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

(2012) T. R. Fenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

CREB Is a Novel Nuclear Target of PTEN Phosphatase

(2011) T. Gu et al.   CANCER RESEARCH

Nuclear PTEN Regulates the APC-CDH1 Tumor-Suppressive Complex in a Phosphatase-Independent Manner

(2011) Min Sup Song et al.   CELL

Coding-Independent Regulation of the Tumor Suppressor PTEN by Competing Endogenous mRNAs

(2011) Yvonne Tay et al.   CELL

In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma

(2011) Florian A. Karreth et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

(2011) Evelyne Lima-Fernandes et al.   EMBO JOURNAL

A continuum model for tumour suppression

(2011) Alice H. Berger et al.   NATURE

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320

(2011) A. Bronisz et al.   NATURE CELL BIOLOGY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways

(2011) Siyuan Zhang et al.   NATURE MEDICINE

On-off system for PI3-kinase-Akt signaling through S-nitrosylation of phosphatase with sequence homology to tensin (PTEN)

(2011) N. Numajiri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

K11-linked ubiquitin chains as novel regulators of cell division

(2011) Katherine E. Wickliffe et al.   TRENDS IN CELL BIOLOGY

A Clinical Scoring System for Selection of Patients for PTEN Mutation Testing Is Proposed on the Basis of a Prospective Study of 3042 Probands

(2010) Min-Han Tan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oncogenic Role of the E3 Ubiquitin Ligase NEDD4-1, a PTEN Negative Regulator, in Non-Small-Cell Lung Carcinomas

(2010) Nicola Amodio et al.   AMERICAN JOURNAL OF PATHOLOGY

The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

(2010) Min Fang et al.   CELL

mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion

(2010) Jae Y. Lee et al.   Cell Stem Cell

MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

(2010) Ji-guang Zhang et al.   CLINICA CHIMICA ACTA

Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2

(2010) Vivian A. Galicia et al.   GASTROENTEROLOGY

Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells

(2010) Lizhi He et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

(2010) Andrea Alimonti et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration

(2010) Young-Don Kwak et al.   Molecular Neurodegeneration

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2

(2010) T. Mund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dlg1-PTEN Interaction Regulates Myelin Thickness to Prevent Damaging Peripheral Nerve Overmyelination

(2010) L. Cotter et al.   SCIENCE

The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes

(2010) A. J. Levine et al.   SCIENCE

Identification of the miR-106b 25 MicroRNA Cluster as a Proto-Oncogenic PTEN-Targeting Intron That Cooperates with Its Host Gene MCM7 in Transformation

(2010) L. Poliseno et al.   Science Signaling

SIRT1 Deficiency Downregulates PTEN/JNK/FOXO1 Pathway to Block Reactive Oxygen Species-Induced Apoptosis in Mouse Embryonic Stem Cells

(2010) Hee-Don Chae et al.   STEM CELLS AND DEVELOPMENT

Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function

(2009) Eun-Kyoung Yim et al.   CANCER CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

(2009) Juxiang Cao et al.   EMBO JOURNAL

Genetic dissection of the miR-17 92 cluster of microRNAs in Myc-induced B-cell lymphomas

(2009) P. Mu et al.   GENES & DEVELOPMENT

X-linked Inhibitor of Apoptosis Protein (XIAP) Regulates PTEN Ubiquitination, Content, and Compartmentalization

(2009) Céline Van Themsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

(2009) Li-Bing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonproteolytic Functions of Ubiquitin in Cell Signaling

(2009) Zhijian J. Chen et al.   MOLECULAR CELL

Pten in stromal fibroblasts suppresses mammary epithelial tumours

(2009) Anthony J. Trimboli et al.   NATURE

MyosinV controls PTEN function and neuronal cell size

(2009) Michiel T. van Diepen et al.   NATURE CELL BIOLOGY

Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN

(2009) L Davidson et al.   ONCOGENE

Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a

(2009) B. Fine et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

PTEN Acetylation Modulates Its Interaction with PDZ Domain

(2008) T. Ikenoue et al.   CANCER RESEARCH

Tenets of PTEN Tumor Suppression

(2008) Leonardo Salmena et al.   CELL

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability

(2008) Ana Silva et al.   JOURNAL OF CLINICAL INVESTIGATION

Repression of PTEN Phosphatase by Snail1 Transcriptional Factor during Gamma Radiation-Induced Apoptosis

(2008) M. Escriva et al.   MOLECULAR AND CELLULAR BIOLOGY

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network

(2008) Min Sup Song et al.   NATURE

Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

(2008) Changchun Xiao et al.   NATURE IMMUNOLOGY

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

(2008) Bryan Heit et al.   NATURE IMMUNOLOGY

The role of PTEN signaling perturbations in cancer and in targeted therapy

(2008) M Keniry et al.   ONCOGENE

Id-1 activates Akt-mediated Wnt signaling and p27Kip1 phosphorylation through PTEN inhibition

(2008) J-Y Lee et al.   ONCOGENE

Understanding PTEN regulation: PIP2, polarity and protein stability

(2008) N R Leslie et al.   ONCOGENE

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN

(2008) M. Rahdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

(2008) F. Fouladkou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

(2008) S. T. Y. Hui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA