Targeting Regulatory T Cells by Addressing Tumor Necrosis Factor and Its Receptors in Allogeneic Hematopoietic Cell Transplantation and Cancer

Stimulation of TNF receptor type 2 expands regulatory T cells and ameliorates established collagen-induced arthritis in mice

(2018) Vanessa Lamontain et al.   Cellular & Molecular Immunology

The Alternative NF-κB Pathway in Regulatory T Cell Homeostasis and Suppressive Function

(2018) Yenkel Grinberg-Bleyer et al.   JOURNAL OF IMMUNOLOGY

Acute Graft-versus-Host Disease

(2018)   NEW ENGLAND JOURNAL OF MEDICINE

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer

(2018) Yingjie Nie et al.   Science Signaling

Lack of Evidence for a Direct Interaction of Progranulin and Tumor Necrosis Factor Receptor-1 and Tumor Necrosis Factor Receptor-2 From Cellular Binding Studies

(2018) Isabell Lang et al.   Frontiers in Immunology

An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function

(2017) Hyunju Oh et al.   IMMUNITY

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells

(2017) Maik Luu et al.   Oncotarget

c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity

(2017) Carlos Plaza-Sirvent et al.   Cell Reports

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Chronic Inflammation Increases the Sensitivity of Mouse Treg for TNFR2 Costimulation

(2017) Tobias Schmid et al.   Frontiers in Immunology

TNF-α priming enhances CD4 + FoxP3 + regulatory T-cell suppressive function in murine GVHD prevention and treatment

(2016) Antonio Pierini et al.   BLOOD

Control of GVHD by regulatory T cells depends on TNF produced by T cells and TNFR2 expressed by regulatory T cells

(2016) M. Leclerc et al.   BLOOD

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing

(2016) Audrey Nosbaum et al.   JOURNAL OF IMMUNOLOGY

Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity

(2016) Chong T. Luo et al.   NATURE

Activation of TNFR2 sensitizes macrophages for TNFR1-mediated necroptosis

(2016) Daniela Siegmund et al.   Cell Death & Disease

A TNFR2-Agonist Facilitates High Purity Expansion of Human Low Purity Treg Cells

(2016) Xuehui He et al.   PLoS One

Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD

(2015) M. Chopra et al.   BLOOD

Principles of antibody-mediated TNF receptor activation

(2015) H Wajant   CELL DEATH AND DIFFERENTIATION

Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages

(2015) Jin Jin et al.   Nature Communications

Blockade of TNF-α signaling benefits cancer therapy by suppressing effector regulatory T cell expansion

(2015) Li-Yuan Chang et al.   OncoImmunology

p100, a precursor of NF-κB2, inhibits c-Rel and reduces the expression of IL-23 in dendritic cells

(2014) Setsuko Mise-Omata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation and dysregulation of tumor necrosis factor receptor-1

(2014) Leen Puimège et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Programmed necrosis and necroptosis signalling

(2014) Maria Feoktistova et al.   FEBS Journal

Targeting tumour necrosis factor receptor 1 assembly reverses Th17-mediated colitis through boosting a Th2 response

(2014) Shin-Huei Fu et al.   GUT

Progranulin promotes tumour necrosis factor-induced proliferation of suppressive mouse CD4+ Foxp3+regulatory T cells

(2014) Ya Hu et al.   IMMUNOLOGY

Cutting Edge: Expression of TNFR2 Defines a Maximally Suppressive Subset of Mouse CD4+CD25+FoxP3+ T Regulatory Cells: Applicability to Tumor-Infiltrating T Regulatory Cells

(2014) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: TNFR-Shedding by CD4+CD25+ Regulatory T Cells Inhibits the Induction of Inflammatory Mediators

(2014) G. J. D. van Mierlo et al.   JOURNAL OF IMMUNOLOGY

Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context

(2014) Audrey Baeyens et al.   JOURNAL OF IMMUNOLOGY

Activated CD8+T Cells Induce Expansion of Vβ5+Regulatory T Cells via TNFR2 Signaling

(2014) Jara J. Joedicke et al.   JOURNAL OF IMMUNOLOGY

Progranulin-Derived Atsttrin Directly Binds to TNFRSF25 (DR3) and Inhibits TNF-Like Ligand 1A (TL1A) Activity

(2014) Cui Liu et al.   PLoS One

Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen-Induced Arthritis

(2014) Fiona E. McCann et al.   Arthritis & Rheumatology

Etanercept for steroid-refractory acute graft versus host disease following allogeneic hematopoietic stem cell transplantation

(2014) Joo Han Park et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Regulatory T Cells as Immunotherapy

(2014) Benjamin D. Singer et al.   Frontiers in Immunology

A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model

(2013) Carina A Bäuerlein et al.   BMC Medicine

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

(2013) Martin Chopra et al.   CARCINOGENESIS

Reducing TNF Receptor 2 + Regulatory T Cells via the Combined Action of Azacitidine and the HDAC Inhibitor, Panobinostat for Clinical Benefit in Acute Myeloid Leukemia Patients

(2013) Chindu Govindaraj et al.   CLINICAL CANCER RESEARCH

Progranulin does not inhibit TNF and lymphotoxin-α signalling through TNF receptor 1

(2013) Nima Etemadi et al.   IMMUNOLOGY AND CELL BIOLOGY

A Role for Tumor Necrosis Factor and Bacterial Antigens in the Pathogenesis of Crohnʼs Disease–Associated Fistulae

(2013) Sandra Michaela Frei et al.   INFLAMMATORY BOWEL DISEASES

In Vivo Maturation of Allo-Specific CD8 CTL and Prevention of Lupus-like Graft-versus-Host Disease Is Critically Dependent on T Cell Signaling through the TNF p75 Receptor But Not the TNF p55 Receptor

(2013) K. Soloviova et al.   JOURNAL OF IMMUNOLOGY

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells

(2013) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

(2013) Hong Nie et al.   NATURE MEDICINE

Intrinsic TNF/TNFR2 Interactions Fine-Tune the CD8 T Cell Response to Respiratory Influenza Virus Infection in Mice

(2013) Michael E. Wortzman et al.   PLoS One

Homogeneous Expansion of Human T-Regulatory Cells Via Tumor Necrosis Factor Receptor 2

(2013) Yoshiaki Okubo et al.   Scientific Reports

TNF-Inhibition with Etanercept for Graft-versus-Host Disease Prevention in High-Risk HCT: Lower TNFR1 Levels Correlate with Better Outcomes

(2012) Sung W. Choi et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

TNF signaling drives myeloid-derived suppressor cell accumulation

(2012) Xueqiang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

TNF-α impairs differentiation and function of TGF-β-induced Treg cells in autoimmune diseases through Akt and Smad3 signaling pathway

(2012) Qi Zhang et al.   Journal of Molecular Cell Biology

Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?

(2011) C. Ustun et al.   BLOOD

TNFR2 on non-haematopoietic cells is required for Foxp3+Treg-cell function and disease suppression in EAE

(2011) Niki Tsakiri et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TNFR1-induced activation of the classical NF-κB pathway

(2011) Harald Wajant et al.   FEBS Journal

Anti-TNF therapy in patients with rheumatoid arthritis decreases Th1 and Th17 cell populations and expands IFN-γ-producing NK cell and regulatory T cell subsets

(2011) Octavio Aravena et al.   IMMUNOBIOLOGY

Targeting pre-ligand assembly domain of TNFR1 ameliorates autoimmune diseases – An unrevealed role in downregulation of Th17 cells

(2011) Yen-Ling Wang et al.   JOURNAL OF AUTOIMMUNITY

TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice

(2011) J. Chee et al.   JOURNAL OF IMMUNOLOGY

Natural but Not Inducible Regulatory T Cells Require TNF-  Signaling for In Vivo Function

(2011) W. J. Housley et al.   JOURNAL OF IMMUNOLOGY

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

(2011) W. Tang et al.   SCIENCE

Targeted tumor necrosis factor receptor I preligand assembly domain improves skin lesions in MRL/lpr mice

(2010) Guo-Min Deng et al.   ARTHRITIS AND RHEUMATISM

A single NFκB system for both canonical and non-canonical signaling

(2010) Vincent Feng-Sheng Shih et al.   CELL RESEARCH

Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse

(2010) Paul L Bollyky et al.   Cellular & Molecular Immunology

Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+regulatory T cells in human peripheral blood

(2010) Xin Chen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Elevated frequencies of CD4+CD25+CD127lo regulatory T cells is associated to poor prognosis in patients with acute myeloid leukemia

(2010) Zhang Shenghui et al.   INTERNATIONAL JOURNAL OF CANCER

Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF CLINICAL INVESTIGATION

Expression of Costimulatory TNFR2 Induces Resistance of CD4+FoxP3- Conventional T Cells to Suppression by CD4+FoxP3+ Regulatory T Cells

(2010) X. Chen et al.   JOURNAL OF IMMUNOLOGY

TNF receptor 2 pathway: drug target for autoimmune diseases

(2010) Denise Faustman et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane Tumor Necrosis Factor (TNF) Induces p100 Processing via TNF Receptor-2 (TNFR2)

(2009) Hilka Rauert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNFR2-Deficient Memory CD8 T Cells Provide Superior Protection against Tumor Cell Growth

(2009) E. Y. Kim et al.   JOURNAL OF IMMUNOLOGY

Tumor necrosis factor receptor-associated factor-1 enhances proinflammatory TNF receptor-2 signaling and modifies TNFR1–TNFR2 cooperation

(2009) A Wicovsky et al.   ONCOGENE

Addition of Infliximab to Standard Acute Graft-versus-Host Disease Prophylaxis following Allogeneic Peripheral Blood Cell Transplantation

(2008) Mehdi Hamadani et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Plasma Elevations of Tumor Necrosis Factor-Receptor-1 at Day 7 Postallogeneic Transplant Correlate with Graft-versus-Host Disease Severity and Overall Survival in Pediatric Patients

(2008) Carrie L. Kitko et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Change in plasma tumor necrosis factor receptor 1 levels in the first week after myeloablative allogeneic transplantation correlates with severity and incidence of GVHD and survival

(2008) S. W. Choi et al.   BLOOD

A biomarker panel for acute graft-versus-host disease

(2008) S. Paczesny et al.   BLOOD