The role of RNA G‐quadruplexes in human diseases and therapeutic strategies

G-Quadruplexes in Human Ribosomal RNA

(2019) Santi Mestre-Fos et al.   JOURNAL OF MOLECULAR BIOLOGY

Stable G-quadruplex enabling sequences are selected against by the context-dependent codon bias

(2019) Gayan Mirihana Arachchilage et al.   GENE

C9orf72 and Triplet Repeat Disorder RNAs: G-quadruplex formation, binding to PRC2 and implications for disease mechanisms

(2019) Xueyin Wang et al.   RNA

Targeting of G-Quadruplex Harboring Pre-miRNA 92b by LNA Rescues PTEN Expression in NSCL Cancer Cells

(2018) Gayan Mirihana Arachchilage et al.   ACS Chemical Biology

G-quadruplex structure at intron 2 of TFE3 and its role in Xp11.2 translocation and splicing

(2018) Shiv Prakash Verma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Comprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5′ UTR of tumor-associated mRNAs

(2018) Tatsuo Serikawa et al.   BIOCHIMIE

An intramolecular antiparallel G-quadruplex formed by human telomere RNA

(2018) Chao-Da Xiao et al.   CHEMICAL COMMUNICATIONS

G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy

(2018) Emanuela Ruggiero et al.   NUCLEIC ACIDS RESEARCH

Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria

(2018) Zbigniew Pietras et al.   Nature Communications

Characterizations of distinct parallel and antiparallel G-quadruplexes formed by two-repeat ALS and FTD related GGGGCC sequence

(2018) Bo Zhou et al.   Scientific Reports

RNA synthesis is modulated by G-quadruplex formation in Hepatitis C virus negative RNA strand

(2018) Jaubert Chloé et al.   Scientific Reports

Analysis of NRAS RNA G-quadruplex binding proteins reveals DDX3X as a novel interactor of cellular G-quadruplex containing transcripts

(2018) Barbara Herdy et al.   NUCLEIC ACIDS RESEARCH

Novel splicing in IGFN1 intron 15 and role of stable G-quadruplex in the regulation of splicing in renal cell carcinoma

(2018) Shiv Prakash Verma et al.   PLoS One

Up- and downregulation of mature miR-1587 function by modulating its G-quadruplex structure and using small molecules

(2018) Fangyuan Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication

(2018) Wen-Xiu Bian et al.   NUCLEIC ACIDS RESEARCH

Transcriptome-wide identification of transient RNA G-quadruplexes in human cells

(2018) Sunny Y. Yang et al.   Nature Communications

A secondary structure within a human piRNA modulates its functionality

(2018) Sumirtha Balaratnam et al.   BIOCHIMIE

Effects of genomic disruption of a guanine quadruplex in the 5′ UTR of the Bcl-2 mRNA in melanoma cells

(2017) Tatsuo Serikawa et al.   FEBS LETTERS

RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF

(2017) Huilin Huang et al.   GENES & DEVELOPMENT

RNA Binding Proteins and Genome Integrity

(2017) Kensei Nishida et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RNA G-Quadruplexes in Kirsten Ras (KRAS) Oncogene as Targets for Small Molecules Inhibiting Translation

(2017) Giulia Miglietta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

(2017) Hong-Liang Bao et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplexes influence pri-microRNA processing

(2017) Samuel G. Rouleau et al.   RNA Biology

3′ UTR G-quadruplexes regulate miRNA binding

(2017) Samuel Rouleau et al.   RNA

Identification of functional tetramolecular RNA G-quadruplexes derived from transfer RNAs

(2017) Shawn M. Lyons et al.   Nature Communications

The Human CCHC-type Zinc Finger Nucleic Acid-Binding Protein Binds G-Rich Elements in Target mRNA Coding Sequences and Promotes Translation

(2017) Daniel Benhalevy et al.   Cell Reports

The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD

(2017) Brian D. Freibaum et al.   Frontiers in Molecular Neuroscience

Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression

(2017) Mahdi Zeraati et al.   Scientific Reports

Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA

(2016) Chun Kit Kwok et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

piRNAs and Their Functions in the Brain

(2016) Lingjun Zuo et al.   INTERNATIONAL JOURNAL OF HUMAN GENETICS

A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

(2016) Yousuke Katsuda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe

(2016) Shuo-Bin Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Piwi-interacting RNAs in cancer: emerging functions and clinical utility

(2016) Kevin W. Ng et al.   Molecular Cancer

Nucleic acid clamp-mediated recognition and stabilization of the physiologically relevant MYC promoter G-quadruplex

(2016) Taisen Hao et al.   NUCLEIC ACIDS RESEARCH

The novel G-quadruplex-containing long non-coding RNA GSEC antagonizes DHX36 and modulates colon cancer cell migration

(2016) K Matsumura et al.   ONCOGENE

G-Quadruplexes Involving Both Strands of Genomic DNA Are Highly Abundant and Colocalize with Functional Sites in the Human Genome

(2016) Andrzej S Kudlicki   PLoS One

RNA G-quadruplexes are globally unfolded in eukaryotic cells and depleted in bacteria

(2016) J. U. Guo et al.   SCIENCE

Probing the G‑quadruplex from hsa-miR-3620-5p and inhibition of its interaction with the target sequence

(2016) Wei Tan et al.   TALANTA

hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression

(2016) Anne Cammas et al.   Oncotarget

Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region

(2016) Pelagia Koukouraki et al.   Open Biology

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

Metal Cations in G-Quadruplex Folding and Stability

(2016) Debmalya Bhattacharyya et al.   Frontiers in Chemistry

Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer

(2016) Yiwen Fang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

An Independently Folding RNA G-Quadruplex Domain Directly Recruits the 40S Ribosomal Subunit

(2015) Debmalya Bhattacharyya et al.   BIOCHEMISTRY

The RNA Stem–Loop to G-Quadruplex Equilibrium Controls Mature MicroRNA Production inside the Cell

(2015) Satyaprakash Pandey et al.   BIOCHEMISTRY

Divalent cation-aided identification of physico-chemical properties of metal ions that stabilize RNA g-quadruplexes

(2015) Sumirtha Balaratnam et al.   BIOPOLYMERS

A Potassium Ion-Dependent RNA Structural Switch Regulates Human Pre-miRNA 92b Maturation

(2015) Gayan Mirihana Arachchilage et al.   CHEMISTRY & BIOLOGY

G-quadruplexes: Emerging roles in neurodegenerative diseases and the non-coding transcriptome

(2015) Roberto Simone et al.   FEBS LETTERS

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing

(2015) Anastassios Vourekas et al.   GENES & DEVELOPMENT

Discovery of Small Molecules for Up-Regulating the Translation of Antiamyloidogenic Secretase, a Disintegrin and Metalloproteinase 10 (ADAM10), by Binding to the G-Quadruplex-Forming Sequence in the 5′ Untranslated Region (UTR) of Its mRNA

(2015) Jie Dai et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Aven recognition of RNA G-quadruplexes regulates translation of the mixed lineage leukemia protooncogenes

(2015) Palaniraja Thandapani et al.   eLife

Amyloid Precursor Protein Translation Is Regulated by a 3’UTR Guanine Quadruplex

(2015) Ezekiel Crenshaw et al.   PLoS One

Discovery of Selective Ligands for Telomeric RNA G-quadruplexes (TERRA) through 19F-NMR Based Fragment Screening

(2014) Miguel Garavís et al.   ACS Chemical Biology

Rationally Induced RNA:DNA G-Quadruplex Structures Elicit an Anticancer Effect by Inhibiting Endogenous eIF-4E Expression

(2014) Debmalya Bhattacharyya et al.   BIOCHEMISTRY

piRNAs: from biogenesis to function

(2014) E.-M. Weick et al.   DEVELOPMENT

RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer

(2014) Andrew L. Wolfe et al.   NATURE

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

The structure, function and evolution of proteins that bind DNA and RNA

(2014) William H. Hudson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unconventional features of C9ORF72 expanded repeat in amyotrophic lateral sclerosis and frontotemporal lobar degeneration

(2014) Sabina Vatovec et al.   NEUROBIOLOGY OF AGING

G-quadruplexes in viruses: function and potential therapeutic applications

(2014) Mathieu Métifiot et al.   NUCLEIC ACIDS RESEARCH

G-Quadruplex Structures Formed by Expanded Hexanucleotide Repeat RNA and DNA from the Neurodegenerative Disease-Linked C9orf72 Gene Efficiently Sequester and Activate Heme

(2014) Jason C. Grigg et al.   PLoS One

G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments

(2014) Pavel Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The folding of 5'-UTR human G-quadruplexes possessing a long central loop

(2014) R. Jodoin et al.   RNA

MiR-92b regulates the cell growth, cisplatin chemosensitivity of A549 non small cell lung cancer cell line and target PTEN

(2013) Yan Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The G-Quadruplex Augments Translation in the 5′ Untranslated Region of Transforming Growth Factor β2

(2013) Prachi Agarwala et al.   BIOCHEMISTRY

The miR-92b functions as a potential oncogene by targeting on Smad3 in glioblastomas

(2013) Zhe Bao Wu et al.   BRAIN RESEARCH

Homeland security in theC. elegansgerm line

(2013) Dionna M Kasper et al.   Epigenetics

The Disease-associated r(GGGGCC)nRepeat from theC9orf72Gene Forms Tract Length-dependent Uni- and Multimolecular RNA G-quadruplex Structures

(2013) Kaalak Reddy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of HIV-1 RNA Dimerization in the Central Region of the Genome and Significance for Viral Evolution

(2013) Dorota Piekna-Przybylska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)nRepeat of theC9orf72Gene and Blocks Interaction of RNA-binding Proteins

(2013) Bita Zamiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of Loops and G-Quartets on the Stability of RNA G-Quadruplexes

(2013) Satyaprakash Pandey et al.   JOURNAL OF PHYSICAL CHEMISTRY B

HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation

(2013) Arivazhagan Rajendran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Stability of RNA quadruplex in open reading frame determines proteolysis of human estrogen receptor α

(2013) Tamaki Endoh et al.   NUCLEIC ACIDS RESEARCH

Exploring mRNA 3′-UTR G-quadruplexes: evidence of roles in both alternative polyadenylation and mRNA shortening

(2013) Jean-Denis Beaudoin et al.   NUCLEIC ACIDS RESEARCH

Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity

(2013) Rosalba Perrone et al.   PLoS One

Biophysical characterization of G-quadruplex forming FMR1 mRNA and of its interactions with different fragile X mental retardation protein isoforms

(2013) A. C. Blice-Baum et al.   RNA

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

A G-Rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing

(2012) Jean-François Fisette et al.   JOURNAL OF NEUROCHEMISTRY

The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary

(2012) E. P. Booy et al.   NUCLEIC ACIDS RESEARCH

The porphyrin TmPyP4 unfolds the extremely stable G-quadruplex in MT3-MMP mRNA and alleviates its repressive effect to enhance translation in eukaryotic cells

(2012) Mark J. Morris et al.   NUCLEIC ACIDS RESEARCH

5'-UTR RNA G-quadruplexes: translation regulation and targeting

(2012) A. Bugaut et al.   NUCLEIC ACIDS RESEARCH

Translational repression of cyclin D3 by a stable G-quadruplex in its 5′ UTR: implications for cell cycle regulation

(2012) Heng-You Weng et al.   RNA Biology

Potential G-quadruplexes in the human long non-coding transcriptome

(2012) Gopal Gunanathan Jayaraj et al.   RNA Biology

G-quadruplexes in RNA biology

(2012) Stefania Millevoi et al.   Wiley Interdisciplinary Reviews-RNA

G–quadruplex RNA structure as a signal for neurite mRNA targeting

(2011) Murugan Subramanian et al.   EMBO REPORTS

Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage

(2011) A. Decorsiere et al.   GENES & DEVELOPMENT

Translational Repression of the Disintegrin and Metalloprotease ADAM10 by a Stable G-quadruplex Secondary Structure in Its 5′-Untranslated Region

(2011) Sven Lammich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Translation by Small RNA-Stabilized mRNA Structures in Human Cells

(2011) Kenichiro Ito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Angiogenin-Induced tRNA Fragments Inhibit Translation Initiation

(2011) Pavel Ivanov et al.   MOLECULAR CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

An RNA G-quadruplex in the 3' UTR of the proto-oncogene PIM1 represses translation

(2011) Amit Arora et al.   RNA Biology

TheBCL-25′ Untranslated Region Contains an RNA G-Quadruplex-Forming Motif That Modulates Protein Expression

(2010) Ramla Shahid et al.   BIOCHEMISTRY

G-quadruplex structures in TP53 intron 3: role in alternative splicing and in production of p53 mRNA isoforms

(2010) Virginie Marcel et al.   CARCINOGENESIS

An RNA G-Quadruplex Is Essential for Cap-Independent Translation Initiation in Human VEGF IRES

(2010) Mark J. Morris et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

Telomeres: protecting chromosomes against genome instability

(2010) Roderick J. O'Sullivan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

(2010) Dennis Gomez et al.   NUCLEIC ACIDS RESEARCH

5'-UTR G-quadruplex structures acting as translational repressors

(2010) J.-D. Beaudoin et al.   NUCLEIC ACIDS RESEARCH

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-ATG-initiated translation directed by microsatellite expansions

(2010) T. Zu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional regulation of telomeric non-coding RNA: Implications on telomere biology, replicative senescence and cancer

(2010) Corrado Caslini   RNA Biology

The Biogenesis and Function of PIWI Proteins and piRNAs: Progress and Prospect

(2009) Travis Thomson et al.   Annual Review of Cell and Developmental Biology

An Unusually Stable G-Quadruplex within the 5′-UTR of the MT3 Matrix Metalloproteinase mRNA Represses Translation in Eukaryotic Cells

(2009) Mark J. Morris et al.   BIOCHEMISTRY

Repression of Translation of Human Estrogen Receptor α by G-Quadruplex Formation

(2009) Graham D. Balkwill et al.   BIOCHEMISTRY

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

TERRA: telomeric repeat-containing RNA

(2009) Brian Luke et al.   EMBO JOURNAL

Role for G-Quadruplex RNA Binding by Epstein-Barr Virus Nuclear Antigen 1 in DNA Replication and Metaphase Chromosome Attachment

(2009) J. Norseen et al.   JOURNAL OF VIROLOGY

Predictable suppression of gene expression by 5′-UTR-based RNA quadruplexes

(2009) Kangkan Halder et al.   NUCLEIC ACIDS RESEARCH

Position and Stability Are Determining Factors for Translation Repression by an RNA G-Quadruplex-Forming Sequence within the 5′ UTR of theNRASProto-oncogene†

(2008) Sunita Kumari et al.   BIOCHEMISTRY

3′ end mRNA processing: molecular mechanisms and implications for health and disease

(2008) Sven Danckwardt et al.   EMBO JOURNAL

Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions

(2008) Shiran Yehezkel et al.   HUMAN MOLECULAR GENETICS