标题
Cryo-EM structures capture the transport cycle of the P4-ATPase flippase
作者
关键词
-
出版物
SCIENCE
Volume 365, Issue 6458, Pages 1149-1155
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2019-08-16
DOI
10.1126/science.aay3353
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Asparagine-905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation
- (2019) Stine A. Mikkelsen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Evolution and a revised nomenclature of P4 ATPases, a eukaryotic family of lipid flippases
- (2019) Michael Palmgren et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Phospholipid subcellular localization and dynamics
- (2018) Yanbo Yang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structures of the gastric proton pump
- (2018) Kazuhiro Abe et al. NATURE
- Real-space refinement in PHENIX for cryo-EM and crystallography
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- New tools for the analysis and validation of cryo-EM maps and atomic models
- (2018) Pavel V. Afonine et al. Acta Crystallographica Section D-Structural Biology
- Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine)
- (2018) Hye-Won Shin et al. FASEB JOURNAL
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis
- (2018) Jasenko Zivanov et al. IUCrJ
- The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane
- (2017) Katsumori Segawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- C-terminus of the P4-ATPase ATP8A2 functions in protein folding and regulation of phospholipid flippase activity
- (2017) Madhavan Chalat et al. MOLECULAR BIOLOGY OF THE CELL
- Protein–phospholipid interplay revealed with crystals of a calcium pump
- (2017) Yoshiyuki Norimatsu et al. NATURE
- Dynamics of P-type ATPase transport revealed by single-molecule FRET
- (2017) Mateusz Dyla et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates
- (2017) Rasmus H. Gantzel et al. Scientific Reports
- On the molecular mechanism of flippase- and scramblase-mediated phospholipid transport
- (2016) Cédric Montigny et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase
- (2016) Bartholomew P. Roland et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta
- (2016) Ray Yu-Ruei Wang et al. eLife
- P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas
- (2016) Jens P. Andersen et al. Frontiers in Physiology
- Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase
- (2015) S. Lee et al. EMBO JOURNAL
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex
- (2015) Mette Laursen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions
- (2015) Alan Brown et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2
- (2014) A. L. Vestergaard et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
- (2014) K. Segawa et al. SCIENCE
- Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution
- (2014) Hannah M. Hankins et al. TRAFFIC
- P4 ATPases: Flippases in Health and Disease
- (2013) Vincent van der Mark et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Auto-inhibition of Drs2p, a Yeast Phospholipid Flippase, by Its Carboxyl-terminal Tail
- (2013) Xiaoming Zhou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state
- (2013) Chikashi Toyoshima et al. NATURE
- Two-gate mechanism for phospholipid selection and transport by type IV P-type ATPases
- (2013) R. D. Baldridge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Missense mutation in the ATPase, aminophospholipid transporter protein ATP8A2 is associated with cerebellar atrophy and quadrupedal locomotion
- (2012) Onur Emre Onat et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Role for Phospholipid Flippase Complex of ATP8A1 and CDC50A Proteins in Cell Migration
- (2012) Utako Kato et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate
- (2012) Aurore Jacquot et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Critical role of a transmembrane lysine in aminophospholipid transport by mammalian photoreceptor P4-ATPase ATP8A2
- (2012) J. A. Coleman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of residues defining phospholipid flippase substrate specificity of type IV P-type ATPases
- (2012) R. D. Baldridge et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P4-ATPase ATP8A2
- (2011) Jonathan A. Coleman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning
- (2011) Kelly Levano et al. JOURNAL OF NEUROCHEMISTRY
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery
- (2010) Susanne Bryde et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Localization, Purification, and Functional Reconstitution of the P4-ATPase Atp8a2, a Phosphatidylserine Flippase in Photoreceptor Disc Membranes
- (2009) Jonathan A. Coleman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of a Golgi flippase by phosphoinositides and an ArfGEF
- (2009) Paramasivam Natarajan et al. NATURE CELL BIOLOGY
- Modulation of protein properties in living cells using nanobodies
- (2009) Axel Kirchhofer et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started