Article
Biochemistry & Molecular Biology
Chia-Li Chung, Yu-Hua Huang, Chien-Ju Lin, Yoon-Bin Chong, Shu-Chuan Wu, Chee-Yin Chai, Hung-Pei Tsai, Aij-Lie Kwan
Summary: This study found that the use of Drp-1 inhibitor Mdivi-1 could alleviate cerebral vasospasm, inflammation, and neuron cell apoptosis following SAH in a hyperglycemic state.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Yue Deng, Shuangyue Li, Zhenzhen Chen, Wenjie Wang, Bin Geng, Jun Cai
Summary: The study showed that inhibiting mitochondrial fission can help prevent and alleviate the development of hypertension.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jie Ding, Zhihao Zhang, Sui Li, Wei Wang, Tingyi Du, Qin Fang, Yan Wang, Dao Wen Wang
Summary: The study found that Mdivi-1 can improve cardiac fibrosis and impaired heart function by reducing mitochondrial fission. In addition, increasing the expression of Hmox1 and inhibiting oxidative stress may be another potential mechanism of action of Mdivi-1.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Medicine, Research & Experimental
Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng, Qing-wei Chen
Summary: Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviated atherogenesis via suppressing mito-ROS/NLRP3-mediated M1 polarization, indicating the potential therapeutic target for AS.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Seul-Gi Yang, Seung-Yeon Joe, Jin-Wook Bae, Gyeong-Deok Heo, Hyo-Jin Park, Deog-Bon Koo
Summary: The study found a close relationship between mitochondrial function and oocyte maturation in pigs, with melatonin being able to rehabilitate meiotic maturation disrupted by Mdivi-1. Melatonin also has direct beneficial effects on meiotic maturation through tubulin formation factors during porcine oocyte maturation, reducing DNA damage and improving spindle assembly.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
P. Finocchietto, H. Perez, G. Blanco, V. Miksztowicz, C. Marotte, C. Morales, J. Peralta, G. Berg, C. Poderoso, J. J. Poderoso, M. C. Carreras
Summary: This study investigates the role of dysregulation of mitochondrial dynamics and biogenesis in an animal model of obesity and diabetes. The findings suggest that pharmacological targeting of Drp-1 fission protein may be a potential novel therapeutic tool for obesity and type 2 diabetes.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Neurosciences
Ela Mishra, Mahendra Kumar Thakur
Summary: This study investigates the role of Mdivi-1 in mitochondrial dynamics, hippocampal plasticity, and memory in scopolamine-induced amnesia. The results indicate that Mdivi-1 treatment improves recognition and spatial memory, as well as mitochondrial ultrastructure. It also reduces neurodegeneration, enhances neuronal health, and increases dendritic arborization and spine density.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Amer Ahmed, Alfonso Trezza, Mariangela Gentile, Eugenio Paccagnini, Pietro Lupetti, Ottavia Spiga, Sergio Bova, Fabio Fusi
Summary: Mdivi-1 is an effective vasorelaxant agent in vitro at concentrations routinely used to block dynamin-related protein-1. Ion channels and pathways key to the maintenance of vessel active tone are involved in this mechanism. These yet undiscovered off-target effects raise caution for the interpretation of mitochondrial fission signaling.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yu Zhu, Lei Kuang, Yue Wu, Haoyue Deng, Han She, Yuanqun Zhou, Jie Zhang, Liangming Liu, Tao Li
Summary: Inhibition of mitochondrial fission using Mdivi-1 was found to antagonize sepsis-induced organ dysfunction and improve mitochondrial function, leading to alleviation of inflammation and cell apoptosis in the heart and vascular smooth muscle. This discovery provides a novel effective candidate therapy for severe sepsis/septic shock and other critical clinical diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Nguyen Thanh Nhu, Qing Li, Yijie Liu, Jian Xu, Shu-Yun Xiao, Shin-Da Lee
Summary: This systematic review evaluated the effects of Mdivi-1 on neural mitochondrial dysfunction and neural mitochondria-mediated apoptosis in I/R-induced brain injury after ischemic stroke. The findings suggest that Mdivi-1 can protect neural mitochondrial functions and reduce neural mitochondria-mediated apoptosis.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Pediatrics
Yuanyuan Dai, Binyuan Yu, Danyang Ai, Lin Yuan, Xinye Wang, Ran Huo, Xiaoqin Fu, Shangqin Chen, Chao Chen
Summary: The study reveals that excessive mitochondrial fission is a critical mediator of hyperoxia-induced pulmonary vascular injury, and inhibition of mitochondrial fission may be an effective treatment for hyperoxia-induced related pulmonary diseases.
FRONTIERS IN PEDIATRICS
(2021)
Article
Oncology
Qiuqiu Zhang, Qianwei Zhang, Huiyuan Li, Xiaofei Zhao, Han Zhang
Summary: Choroidal melanoma is commonly found in adults and lithium chloride has been shown to induce apoptosis in leukemia cells. In this study, lithium chloride was found to inhibit cell survival and clonogenic potential, induce apoptosis, and reduce proliferation of choroidal melanoma cells both in vitro and in vivo. The upregulation of NOXA and downregulation of Mcl-1 were identified as key factors in lithium chloride-induced apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Jui-Chih Chang, Huei-Shin Chang, Cheng-Yi Yeh, Hui-Ju Chang, Wen-Ling Cheng, Ta-Tsung Lin, Chin-San Liu, Shou-Tung Chen
Summary: Validating the method of treating breast cancer by increasing mitochondrial fusion is necessary. This study found that the antitumor effect of membrane-fused mitochondria and mitochondrial division inhibitor differed in the treatment of breast cancer. Moreover, membrane-fused mitochondria enhanced drug sensitivity by inducing mitophagy, while mitochondrial division inhibitor induced cell death through a caspase-dependent pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Francesca Ricci, Alessandro Corbelli, Roberta Affatato, Rosaria Chila, Michela Chiappa, Laura Brunelli, Robert Fruscio, Roberta Pastorelli, Fabio Fiordaliso, Giovanna Damia
Summary: Our study found that acquisition of DDP resistance is associated with morphological alterations in mitochondria, despite the lack of dysregulation in the studied genes/proteins that could explain the observed differences.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Chayodom Maneechote, Siripong Palee, Sasiwan Kerdphoo, Thidarat Jaiwongkam, Siriporn C. Chattipakorn, Nipon Chattipakorn
Summary: Inhibiting mitochondrial fission and promoting mitochondrial fusion can reduce infarct size and improve left ventricular function in cardiac ischemia-reperfusion injury.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Giovanni Quarato, Fabien Llambi, Cliff S. Guy, Jaeki Min, Marisa Actis, Huan Sun, Shilpa Narina, Shondra M. Pruett-Miller, Junmin Peng, Zoran Rankovic, Douglas R. Green
Summary: The imbalance of intracellular Ca2+ and mitochondrial Ca2+ overload can lead to mitochondrial inner membrane permeabilization and cell death, which is distinct from Bcl-2 family-regulated mitochondrial outer membrane permeabilization. Cyclosporin A can prevent cell death by inhibiting Ca2+ release from endoplasmic reticulum stores.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Multidisciplinary Sciences
Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Sujing Yuan, Piyush Sharma, Jon P. Connelly, Swantje Liedmann, Yogesh Dhungana, Zhenrui Li, Dalia Haydar, Mao Yang, Helen Beere, Jason T. Yustein, Christopher DeRenzo, Shondra M. Pruett-Miller, Jeremy Chase Crawford, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
Summary: This study identifies components of the cBAF complex as negative regulators of T-mem cell generation and provides insights into the asymmetric distribution of cBAF and MYC during the division of activated CD8+ T cells. Manipulation of cBAF early in T cell differentiation has the potential to improve cancer immunotherapy, as demonstrated in a mouse solid tumor model.
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Bart Tummers, Douglas R. Green
Summary: Apoptosis and necroptosis, two forms of cell death, play crucial roles in organismal biology and human diseases. While TNF is well-known to induce these processes, cells can also engage in apoptosis and necroptosis through TNF-independent mechanisms, involving the activation of other receptors and proteins such as TLR-3, TLR-4, and ZBP1. RIPK3 is a key regulator of TNF-independent cell death, mediating both apoptosis and necroptosis in response to TLR3/4 and ZBP1 engagement.
BIOCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Halime Kalkavan, Mark J. Chen, Jeremy C. Crawford, Giovanni Quarato, Patrick Fitzgerald, Stephen W. G. Tait, Colin R. Goding, Douglas R. Green
Summary: Drug-tolerant persister cells can evade apoptosis and have the ability to colonize and metastasize. These cells also show increased sensitivity to ferroptosis. The release of cytochrome c plays a crucial role in the generation of these drug-tolerant persister cells.
Correction
Multidisciplinary Sciences
Jennifer Martinez, Larissa D. Cunha, Sunmin Park, Mao Yang, Qun Lu, Robert Orchard, Quan-Zhen Li, Mei Yan, Laura Janke, Cliff Guy, Andreas Linkermann, Herbert W. Virgin, Douglas R. Green
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Meeting Abstract
Immunology
Erin E. West, Simon Freeley, Marcin M. Kaminski, Nicolas S. Merle, Sharon Veenbergen, Duck-Yeon Lee, Lisa St. John-Williams, J. Will Thompson, Douglas R. Green, Sabine Scholl-Buergi, Daniela Karall, Martina Huemer, Claudia Kemper
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Swarna Beesetti, Rhea Sumpter, Douglas R. Green
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Immunology
Ao Guo, Hongling Huang, Zhexin Zhu, Mark J. Chen, Hao Shi, Piyush Sharma, Swantje Liedmann, Dalia Haydar, Mao Yang, Helen Beere, Giedre Krenciute, Charles W. M. Roberts, Hongbo Chi, Douglas R. Green
JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)
Article
Cell Biology
Douglas R. Green
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2022)