Article
Cell Biology
Yadong Sun, Niklas Berleth, Wenxian Wu, David Schluetermann, Jana Deitersen, Fabian Stuhldreier, Lena Berning, Annabelle Friedrich, Seda Akguen, Maria Jose Mendiburo, Sebastian Wesselborg, Marcus Conrad, Carsten Berndt, Bjorn Stork
Summary: Fin56 induces ferroptosis and autophagy in bladder cancer cells, with ferroptosis mechanistically depending on the autophagic machinery. Inhibition of autophagy at different stages attenuates Fin56-induced oxidative stress and GPX4 degradation. Additionally, the combination of Fin56 and Torin 2 synergistically enhances cytotoxicity against bladder cancer cells. The findings suggest that the crosstalk between ferroptosis and autophagy, along with the use of mTOR inhibitors, may offer a promising therapeutic strategy for bladder cancer.
CELL DEATH & DISEASE
(2021)
Review
Chemistry, Multidisciplinary
Rahela Zaman, Rowshan Ara Islam, Ezharul Hoque Chowdhury
Summary: The established cancer treatment strategy based on chemo and radiation therapy has limitations due to severe side-effects and drug-resistance. Peptide and protein-based precision therapeutics can target specific tumor tissues, reducing drug toxicity and potentially reshaping the treatment approach.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Biochemistry & Molecular Biology
Jun-Ping Shiau, Ya-Ting Chuang, Jen-Yang Tang, Kun-Han Yang, Fang-Rong Chang, Ming-Feng Hou, Ching-Yu Yen, Hsueh-Wei Chang
Summary: Oxidative stress and AKT pathway play crucial roles in regulating various cell functions in cancer cells. Natural products have the potential to modulate oxidative stress and AKT for anticancer effects. However, the underlying mechanisms of how they regulate cell functions, particularly the contribution of AKT downstream effectors, are not well understood. This review discusses the roles of oxidative stress and AKT pathway in ten cell functions and highlights the potential of natural products in regulating these functions, with a focus on AKT effectors that have been rarely reported.
Article
Oncology
Dawid Glow, Cecile L. Maire, Lea Isabell Schwarze, Katrin Lamszus, Boris Fehse
Summary: By targeting highly repetitive Alu sequences with CRISPR-to-kill (C2K) lentiviral vectors, effective killing of human cells and inhibition of cancer cell growth, including patient-derived glioblastoma cells resistant to high-dose radiation, were achieved, providing proof-of-concept for a novel treatment strategy overcoming common resistance mechanisms.
Article
Biochemistry & Molecular Biology
Jun Bai, Jun Li, Ning Liu, Hai Jia, Xuemeng Si, Yusong Zhou, Zhian Zhai, Ying Yang, Fazheng Ren, Zhenlong Wu
Summary: This study found that glucosamine can protect porcine trophectoderm (pTr) cells from apoptosis and oxidative damage induced by zearalenone. Further research suggests that glucosamine exerts its protective effect by activating the PI3K/AKT signaling pathway. These findings provide a theoretical basis for the application of glucosamine in alleviating impaired early embryo development.
Article
Food Science & Technology
Yuening Sun, Wenjing Guo, Yongjian Guo, Zhangxing Lin, Dechao Wang, Qinglong Guo, Yuxin Zhou
Summary: The study demonstrated that wogonin could induce apoptosis of prostate cancer cells by regulating fatty acid metabolism and activating signaling pathways, showing promising anti-tumor effects.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wojciech Trybus, Ewa Trybus, Teodora Krol
Summary: This study evaluated the effects of combining emodin with vinblastine on cervical cancer cells. The combination increased oxidative stress, mitotic catastrophe, and apoptosis, potentially offering a promising approach for anticancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Hematology
Kaosheng Lv, Wei Tong
Summary: In this study, Zhao et al found that downregulation of MS4A3 contributes to the persistence, progression, and drug resistance of chronic myeloid leukemia (CML) to the BCR-ABL inhibitor imatinib. Thus, enhancing MS4A3 levels could be a potential therapeutic strategy in treating CML.
Editorial Material
Multidisciplinary Sciences
Philipp Poeller, Almut Schulze
Summary: Mutated forms of Akt protein play a central role in driving cancer metabolism by promoting the synthesis of coenzyme A, thereby broadening our understanding of its activity.
Article
Multidisciplinary Sciences
Sumit Sen Santara, Angela C. Crespo, Sachin Mulik, Cristian Ovies, Selma Boulenouar, Jack L. Strominger, Judy Lieberman
Summary: Zika virus infection during pregnancy can lead to placental damage and fetal birth defects, with limited understanding of the cellular immune response at the maternal-fetal interface. Research has shown that dNK cells in the first trimester are able to kill Zika virus-infected trophoblasts, indicating that certain immune cells protect the fetus by eliminating infected cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ye Zhao, Qin Jiang, Xuefei Zhang, Xiaoxiao Zhu, Xia Dong, Linyuan Shen, Shunhua Zhang, Lili Niu, Lei Chen, Ming Zhang, Jun Jiang, Daiwen Chen, Li Zhu
Summary: l-Arginine has been shown to reduce muscle injury by regulating the SIRT1-Akt-Nrf2 and SIRT1-FOXO3a-mitochondria apoptosis signaling pathways as a potential nutraceutical.
Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Jun-Ping Shiau, Jen-Yang Tang, Chia-Hung Yen, Ming-Feng Hou, Yuan-Bin Cheng, Chih-Wen Shu, Hsueh-Wei Chang
Summary: The study demonstrates that PHA can induce autophagy in breast cancer cells, and autophagy inhibitors can enhance the cytotoxic effects of PHA. Furthermore, PHA increases ROS levels, while ROS scavenger NAC decreases PHA-induced autophagy activity. Autophagy inhibitors also enhance PHA-induced apoptosis, while NAC blocks apoptosis. This suggests that autophagy induced by PHA plays an antioxidant and anti-apoptotic role in breast cancer cells.
Article
Biochemistry & Molecular Biology
Tongkuo Yuan, Jia Hu, Xiaoming Zhu, Huancai Yin, Jian Yin
Summary: This paper evaluated the role of oxidative stress in the regulation of ABC transporters in human lung cancer cells, and found that it plays an important role in the modulation of ABC transporter expression and activity, as well as chemical toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell Biology
Hang Huang, Ping Li, Xueting Ye, Fangyi Zhang, Qi Lin, Keming Wu, Wei Chen
Summary: This study found that combination treatment of isoalantolactone (IATL) and cisplatin showed significantly enhanced growth inhibition and apoptosis in human prostate cancer cells, potentially through excessive accumulation of intracellular reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress and the JNK signaling pathway. In vivo, the combined treatment also exhibited the strongest anti-tumor effects compared to single agents, suggesting that IATL and cisplatin combination therapy may be more effective for treating prostate cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
