Targeting T cell metabolism in the tumor microenvironment: an anti-cancer therapeutic strategy

The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells

(2019) Esperanza Perucha et al.   Nature Communications

Tumor Microenvironment-Activatable Prodrug Vesicles for Nanoenabled Cancer Chemoimmunotherapy Combining Immunogenic Cell Death Induction and CD47 Blockade

(2019) Fangyuan Zhou et al.   ADVANCED MATERIALS

Cholesterol Induces CD8+ T Cell Exhaustion in the Tumor Microenvironment

(2019) Xingzhe Ma et al.   Cell Metabolism

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy

(2019) Yu-Xue Zhang et al.   NANO LETTERS

Autophagy Regulation of Metabolism Is Required for CD8+ T Cell Anti-tumor Immunity

(2019) Lindsay DeVorkin et al.   Cell Reports

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells

(2019) Dana M. Previte et al.   Cell Reports

HIF-1α Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma

(2019) Jason Miska et al.   Cell Reports

Acetate Promotes T Cell Effector Function during Glucose Restriction

(2019) Jing Qiu et al.   Cell Reports

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

(2019) Zhilin Hu et al.   Cell Metabolism

Targeting the tumor microenvironment and T cell metabolism for effective cancer immunotherapy

(2019) Helen Carrasco Hope et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

(2019) Chang Liu et al.   IMMUNITY

The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming

(2019) Xiaofei Zhou et al.   NATURE IMMUNOLOGY

Deficient glucose uptake is linked to impaired Glut1 expression upon CD3/CD28 stimulation in memory T cells from pleural effusions secondary to lung cancer

(2019) Heriberto Prado‐Garcia et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes

(2019) Jesús Ogando et al.   Journal for ImmunoTherapy of Cancer

Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

(2019) Paramita Chakraborty et al.   Cell Reports

N-acetyl cysteine protects anti-melanoma cytotoxic T cells from exhaustion induced by rapid expansion via the downmodulation of Foxo1 in an Akt-dependent manner

(2018) Matthew J. Scheffel et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cholesterol negatively regulates IL-9–producing CD8+T cell differentiation and antitumor activity

(2018) Xingzhe Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3K–Akt signaling controls PFKFB3 expression during human T-lymphocyte activation

(2018) Helga Simon-Molas et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Metabolic exhaustion in infection, cancer and autoimmunity

(2018) E. F. McKinney et al.   NATURE IMMUNOLOGY

Metabolic Control of CD8 + T Cell Fate Decisions and Antitumor Immunity

(2018) Lianjun Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

(2018) Asha Nayak-Kapoor et al.   Journal for ImmunoTherapy of Cancer

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome

(2018) Xiaoyan Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

(2018) Tengfei Zhang et al.   JOURNAL OF IMMUNOLOGY

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

(2018) Jong-Ho Cha et al.   MOLECULAR CELL

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond

(2018) Alexander J. Muller et al.   Seminars in Immunopathology

Reinforce the antitumor activity of CD8+ T cells via glutamine restriction

(2018) Shogo Nabe et al.   CANCER SCIENCE

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Targeting PIM Kinase with PD1 inhibition Improves Immunotherapeutic Antitumor T-cell Response

(2018) Shilpak Chatterjee et al.   CLINICAL CANCER RESEARCH

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression

(2018) Christopher M. Rice et al.   Nature Communications

Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism

(2017) Tao Xu et al.   NATURE

Culturing CTLs under Hypoxic Conditions Enhances Their Cytolysis and Improves Their Anti-tumor Function

(2017) Yael Gropper et al.   Cell Reports

Impact of Metabolism in on T-Cell Differentiation and Function and Cross Talk with Tumor Microenvironment

(2017) Soumaya Kouidhi et al.   Frontiers in Immunology

A human programmed death-ligand 1-expressing mouse tumor model for evaluating the therapeutic efficacy of anti-human PD-L1 antibodies

(2017) Anfei Huang et al.   Scientific Reports

A comprehensive characterization of the impact of mycophenolic acid on the metabolism of Jurkat T cells

(2017) Ana A. Fernández-Ramos et al.   Scientific Reports

The effect of immunosuppressive molecules on T-cell metabolic reprogramming

(2016) Ana A. Fernández-Ramos et al.   BIOCHIMIE

T-cell immunometabolism against cancer

(2016) Shuai Jiang et al.   CANCER LETTERS

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

(2016) Wei Yang et al.   NATURE

Oxidized Low‐Density Lipoprotein (OxLDL)–Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let‐7c Is Integral to the Effect

(2016) Johan Frostegård et al.   Journal of the American Heart Association

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Definition of Prostaglandin E2-EP2 Signals in the Colon Tumor Microenvironment That Amplify Inflammation and Tumor Growth

(2015) X. Ma et al.   CANCER RESEARCH

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

(2015) Ping-Chih Ho et al.   CELL

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

(2015) Chih-Hao Chang et al.   CELL

T cell metabolic reprogramming and plasticity

(2015) Maria Slack et al.   MOLECULAR IMMUNOLOGY

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation

(2015) Nikolaos Patsoukis et al.   Nature Communications

T lymphocyte regulation by mevalonate metabolism

(2015) Martin Thurnher et al.   Science Signaling

The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection

(2014) Matthew M. Staron et al.   IMMUNITY

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

(2013) Yoko Kidani et al.   NATURE IMMUNOLOGY

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT-1

(2012) Clara Påhlman et al.   TRANSPLANT INTERNATIONAL

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

(2011) Christiane A. Opitz et al.   NATURE

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The engine driving the ship: metabolic steering of cell proliferation and death

(2010) Marisa R. Buchakjian et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL