PLK4: a promising target for cancer therapy

Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer

(2019) Amreena Suri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role for polo-like kinase 4 in mediation of cytokinesis

(2019) Michael F. Press et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fast and furious . . . or not, Plk4 dictates the pace

(2018) Simon Gemble et al.   JOURNAL OF CELL BIOLOGY

Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

(2018) Carla A.M. Lopes et al.   JOURNAL OF CELL BIOLOGY

Abnormally high expression of POLD1, MCM2, and PLK4 promotes relapse of acute lymphoblastic leukemia

(2018) Sheng Li et al.   MEDICINE

Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma

(2018) Ryan A. Denu et al.   MOLECULAR CANCER RESEARCH

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

(2018) Masanori Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4 mediates epithelial–mesenchymal transition in neuroblastoma via PI3K/Akt signaling pathway

(2018) Xiangdong Tian et al.   Cell Death & Disease

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition

(2018) Masanori Kawakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YLT-11, a novel PLK4 inhibitor, inhibits human breast cancer growth via inducing maladjusted centriole duplication and mitotic defect

(2018) Qian Lei et al.   Cell Death & Disease

MiR-126 negatively regulates PLK-4 to impact the development of hepatocellular carcinoma via ATR/CHEK1 pathway

(2018) Jie Bao et al.   Cell Death & Disease

PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma

(2018) Zuoxin Zhang et al.   CANCER LETTERS

PLK4: a link between centriole biogenesis and cancer

(2017) Radhika Radha Maniswami et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

(2017) Simone Treiger Sredni et al.   PEDIATRIC BLOOD & CANCER

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

(2017) Edward J. Morris et al.   Nature Communications

Inhibition of polo-like kinase 4 (PLK4): a new therapeutic option for rhabdoid tumors and pediatric medulloblastoma

(2017) Simone Treiger Sredni et al.   Oncotarget

Forces positioning the mitotic spindle: Theories, and now experiments

(2016) Hai-Yin Wu et al.   BIOESSAYS

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

(2016) Ryan A. Denu et al.   BMC CANCER

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis

(2016) Sihem Zitouni et al.   CURRENT BIOLOGY

Recurrent genetic defects in classical Hodgkin lymphoma cell lines

(2016) S. David Hudnall et al.   LEUKEMIA & LYMPHOMA

KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification

(2016) Marjorie Fournier et al.   Nature Communications

Activity of the novel polo-like kinase 4 inhibitor CFI-400945 in pancreatic cancer patient-derived xenografts

(2016) Ines Lohse et al.   Oncotarget

Expression of Polo-Like Kinase 4(PLK4) in Breast Cancer and Its Response to Taxane-Based Neoadjuvant Chemotherapy

(2016) Zhenhua Li et al.   Journal of Cancer

Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma

(2015) Karuna Mittal et al.   CELL CYCLE

Development of Bifunctional Inhibitors of Polo-Like Kinase 1 with Low-Nanomolar Activities Against the Polo-Box Domain

(2015) Andrej Scharow et al.   CHEMBIOCHEM

The deregulated promoter methylation of thePolo-like kinasesas a potential biomarker in hematological malignancies

(2015) Alejandra Ward et al.   LEUKEMIA & LYMPHOMA

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes

(2015) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Understanding the Polo Kinase machine

(2015) V Archambault et al.   ONCOGENE

The role of Plk3 in oncogenesis

(2015) C Helmke et al.   ONCOGENE

Epidermal development, growth control, and homeostasis in the face of centrosome amplification

(2015) Anita Kulukian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition and relief mechanism for Polo-like kinase 4

(2015) Joseph E. Klebba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy?

(2014) Andrew J. Holland et al.   CANCER CELL

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer

(2014) Kazuya Shinmura et al.   MOLECULAR BIOLOGY REPORTS

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A novel role for Plk4 in regulating cell spreading and motility

(2014) C O Rosario et al.   ONCOGENE

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

(2014) Alejandra Ward et al.   PLoS One

NFκB regulates expression of Polo-like kinase 4

(2013) Adeline Ledoux et al.   CELL CYCLE

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

(2013) Takanori Nakamura et al.   Nature Communications

Centrosome amplification in tumorigenesis

(2012) Simon J. Anderhub et al.   CANCER LETTERS

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

(2012) Marianne Quaas et al.   CELL CYCLE

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis

(2012) Andrew J. Holland et al.   MOLECULAR BIOLOGY OF THE CELL

NMS-P937, an Orally Available, Specific Small-Molecule Polo-like Kinase 1 Inhibitor with Antitumor Activity in Solid and Hematologic Malignancies

(2012) B. Valsasina et al.   MOLECULAR CANCER THERAPEUTICS

Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis

(2012) Lili Liu et al.   PLoS One

Polo Boxes Come out of the Crypt: A New View of PLK Function and Evolution

(2012) Swadhin Chandra Jana et al.   STRUCTURE

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

(2012) Lauren K. Slevin et al.   STRUCTURE

An in-vitro evaluation of the polo-like kinase inhibitor GW843682X against paediatric malignancies

(2011) Kristina Spaniol et al.   ANTI-CANCER DRUGS

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

(2011) Alejandra Ward et al.   BMC CANCER

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Plk4 is required for cytokinesis and maintenance of chromosomal stability

(2010) C. O. Rosario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

Oncogenic and tumor suppressive roles of polo-like kinases in human hepatocellular carcinoma

(2009) Rossella Pellegrino et al.   HEPATOLOGY

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE