Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

Structural centrosome aberrations promote non‐cell‐autonomous invasiveness

(2018) Olivier Ganier et al.   EMBO JOURNAL

The PIDDosome activates p53 in response to supernumerary centrosomes

(2017) Luca L. Fava et al.   GENES & DEVELOPMENT

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

Evaluation of Mutational Testing of Preneoplastic Barrett's Mucosa by Next-Generation Sequencing of Formalin-Fixed, Paraffin-Embedded Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus

(2015) Armando Del Portillo et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Paired exome analysis of Barrett's esophagus and adenocarcinoma

(2015) Matthew D Stachler et al.   NATURE GENETICS

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

(2015) Caryn S Ross-Innes et al.   NATURE GENETICS

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Excess centrosomes disrupt endothelial cell migration via centrosome scattering

(2014) Erich J. Kushner et al.   JOURNAL OF CELL BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity

(2014) Andriy Marusyk et al.   NATURE

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis

(2014) Jamie M J Weaver et al.   NATURE GENETICS

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

British Society of Gastroenterology guidelines on the diagnosis and management of Barrett's oesophagus

(2013) Rebecca C Fitzgerald et al.   GUT

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins

(2012) Kai Jiang et al.   CURRENT BIOLOGY

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

The Centrosome in Cells and Organisms

(2012) M. Bornens   SCIENCE

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Total Cancer Incidence and Overall Mortality Are Not Increased Among Patients With Barrett's Esophagus

(2011) Leo J. Schouten et al.   Clinical Gastroenterology and Hepatology

American Gastroenterological Association Medical Position Statement on the Management of Barrett's Esophagus

(2011)   GASTROENTEROLOGY

Incidence of Adenocarcinoma among Patients with Barrett's Esophagus

(2011) Frederik Hvid-Jensen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11

(2011) J E Noll et al.   ONCOGENE

Centrosomes and cilia in human disease

(2011) Mónica Bettencourt-Dias et al.   TRENDS IN GENETICS

Novel staining pattern of p53 in Barrett’s dysplasia - the absent pattern

(2010) Philip V Kaye et al.   HISTOPATHOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Verification and Unmasking of Widely Used Human Esophageal Adenocarcinoma Cell Lines

(2010) Jurjen J. Boonstra et al.   JNCI-Journal of the National Cancer Institute

Prevention of Catheter-Related Bacteremia with a Daily Ethanol Lock in Patients with Tunnelled Catheters: A Randomized, Placebo-Controlled Trial

(2010) Lennert Slobbe et al.   PLoS One

Chromosomal Instability and Copy Number Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma

(2009) T. G. Paulson et al.   CLINICAL CANCER RESEARCH

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation

(2008) Maria Emanuela Cuomo et al.   NATURE CELL BIOLOGY