PLK4: a link between centriole biogenesis and cancer

Maternal common variant rs2305957 spanning PLK4 is associated with blastocyst formation and early recurrent miscarriage

(2017) Qian Zhang et al.   FERTILITY AND STERILITY

A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain

(2017) Simone Treiger Sredni et al.   PEDIATRIC BLOOD & CANCER

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

(2017) Edward J. Morris et al.   Nature Communications

Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton

(2016) Karineh Kazazian et al.   CANCER RESEARCH

A non‐canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation

(2016) Akiko Hori et al.   EMBO REPORTS

Expression of Polo-Like Kinase 4(PLK4) in Breast Cancer and Its Response to Taxane-Based Neoadjuvant Chemotherapy

(2016) Zhenhua Li et al.   Journal of Cancer

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Discovery of orally active anticancer candidate CFI-400945 derived from biologically promising spirooxindoles: Success and challenges

(2015) Bin Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis

(2015) L.  ajanek et al.   JOURNAL OF CELL SCIENCE

The deregulated promoter methylation of thePolo-like kinasesas a potential biomarker in hematological malignancies

(2015) Alejandra Ward et al.   LEUKEMIA & LYMPHOMA

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Chronic centrosome amplification without tumorigenesis

(2015) Benjamin Vitre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autoinhibition and relief mechanism for Polo-like kinase 4

(2015) Joseph E. Klebba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos

(2015) R. C. McCoy et al.   SCIENCE

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

Loss of KLF14 triggers centrosome amplification and tumorigenesis

(2015) Guangjian Fan et al.   Nature Communications

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

CAND1 Promotes PLK4-Mediated Centriole Overduplication and Is Frequently Disrupted in Prostate Cancer

(2015) Nina Korzeniewski et al.   NEOPLASIA

Polo-like Kinase 4 Inhibition: A Strategy for Cancer Therapy?

(2014) Andrew J. Holland et al.   CANCER CELL

Functional Characterization of CFI-400945, a Polo-like Kinase 4 Inhibitor, as a Potential Anticancer Agent

(2014) Jacqueline M. Mason et al.   CANCER CELL

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance

(2014) Mihaela Marina   Frontiers in Bioscience-Landmark

Mutation inPLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism

(2014) Ranad Shaheen et al.   JOURNAL OF MEDICAL GENETICS

The Discovery of Polo-Like Kinase 4 Inhibitors: Identification of (1R,2S)-2-(3-((E)-4-(((cis)-2,6-Dimethylmorpholino)methyl)styryl)-1H-indazol-6-yl)-5′-methoxyspiro[cyclopropane-1,3′-indolin]-2′-one (CFI-400945) as a Potent, Orally Active Antitumor Agent

(2014) Peter B. Sampson et al.   JOURNAL OF MEDICINAL CHEMISTRY

E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells

(2014) M.-Y. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy

(2014) Carol-Anne Martin et al.   NATURE GENETICS

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

(2014) Suk-Youl Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel role for Plk4 in regulating cell spreading and motility

(2014) C O Rosario et al.   ONCOGENE

p53-Dependent and Cell Specific Epigenetic Regulation of the Polo-like kinases under Oxidative Stress

(2014) Alejandra Ward et al.   PLoS One

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

NFκB regulates expression of Polo-like kinase 4

(2013) Adeline Ledoux et al.   CELL CYCLE

Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number

(2013) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles

(2013) Paula A. Coelho et al.   DEVELOPMENTAL CELL

Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication

(2013) K. F. Sonnen et al.   JOURNAL OF CELL SCIENCE

The Discovery of PLK4 Inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as Novel Antiproliferative Agents

(2013) Radoslaw Laufer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Centrosome amplification causes microcephaly

(2013) Véronique Marthiens et al.   NATURE CELL BIOLOGY

Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response

(2013) H. Christian Reinhardt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

(2013) Martin Fischer et al.   NUCLEIC ACIDS RESEARCH

Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152

(2013) T.-S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

(2013) Takanori Nakamura et al.   Nature Communications

GF-15, a Novel Inhibitor of Centrosomal Clustering, Suppresses Tumor Cell Growth In Vitro and In Vivo

(2012) M. S. Raab et al.   CANCER RESEARCH

Supernumerary Centrosomes Nucleate Extra Cilia and Compromise Primary Cilium Signaling

(2012) Moe R. Mahjoub et al.   CURRENT BIOLOGY

The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle

(2012) A. J. Holland et al.   GENES & DEVELOPMENT

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

(2012) Aurélien Courtois et al.   JOURNAL OF CELL BIOLOGY

Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes

(2012) P. W. Jordan et al.   JOURNAL OF CELL SCIENCE

Downregulation of Polo-Like Kinase 4 in Hepatocellular Carcinoma Associates with Poor Prognosis

(2012) Lili Liu et al.   PLoS One

The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

(2012) Lauren K. Slevin et al.   STRUCTURE

3D-structured illumination microscopy provides novel insight into architecture of human centrosomes

(2012) Katharina F. Sonnen et al.   Biology Open

Aberrant methylation of Polo-like kinase CpG islands in Plk4 heterozygous mice

(2011) Alejandra Ward et al.   BMC CANCER

Structural Basis of the 9-Fold Symmetry of Centrioles

(2011) Daiju Kitagawa et al.   CELL

Polo-like kinase 4 phosphorylates Chk2

(2011) Steve Petrinac et al.   CELL CYCLE

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

(2011) G. de Carcer et al.   MOLECULAR AND CELLULAR BIOLOGY

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

(2011) Nina Korzeniewski et al.   Molecular Cancer

The SCF–FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication

(2011) Anja Puklowski et al.   NATURE CELL BIOLOGY

CDK11p58 Is Required for Centriole Duplication and Plk4 Recruitment to Mitotic Centrosomes

(2011) Nathalie Franck et al.   PLoS One

Structures of SAS-6 Suggest Its Organization in Centrioles

(2011) M. van Breugel et al.   SCIENCE

SCF ubiquitin ligases in the maintenance of genome stability

(2011) Joshua S. Silverman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genomic instability and cancer: Lessons learned from human papillomaviruses

(2010) Nina Korzeniewski et al.   CANCER LETTERS

A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis

(2010) Susana Godinho et al.   CELL CYCLE

Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy

(2010) Christian Tovar et al.   CELL CYCLE

Centriole duplication

(2010) Andrew J. Holland et al.   CELL CYCLE

Regulated protein kinases and phosphatases in cell cycle decisions

(2010) Bela Novak et al.   CURRENT OPINION IN CELL BIOLOGY

Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation

(2010) Eric Hervouet et al.   Epigenetics

Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability

(2010) Andrew J. Holland et al.   JOURNAL OF CELL BIOLOGY

Stepwise evolution of the centriole-assembly pathway

(2010) Z. Carvalho-Santos et al.   JOURNAL OF CELL SCIENCE

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Plk4 is required for cytokinesis and maintenance of chromosomal stability

(2010) C. O. Rosario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polo-like kinase 4: the odd one out of the family

(2010) James E Sillibourne et al.   Cell Division

Centrosome abnormalities during aChlamydia trachomatisinfection are caused by dysregulation of the normal duplication pathway

(2009) Kirsten A. Johnson et al.   CELLULAR MICROBIOLOGY

Polo Kinase and Separase Regulate the Mitotic Licensing of Centriole Duplication in Human Cells

(2009) Meng-Fu Bryan Tsou et al.   DEVELOPMENTAL CELL

The SCFSlimbubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

(2009) Gregory C. Rogers et al.   JOURNAL OF CELL BIOLOGY

hPOC5 is a centrin-binding protein required for assembly of full-length centrioles

(2009) Juliette Azimzadeh et al.   JOURNAL OF CELL BIOLOGY

 -Tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells

(2009) R. Kuriyama et al.   JOURNAL OF CELL SCIENCE

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Primary Cilia and Signaling Pathways in Mammalian Development, Health and Disease

(2009) Iben R. Veland et al.   NEPHRON PHYSIOLOGY

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through Degradation of SAK/PLK4

(2008) Inês Cunha-Ferreira et al.   CURRENT BIOLOGY

CP110 Suppresses Primary Cilia Formation through Its Interaction with CEP290, a Protein Deficient in Human Ciliary Disease

(2008) William Y. Tsang et al.   DEVELOPMENTAL CELL

Activation of Polo-like Kinase 3 by Hypoxic Stresses

(2008) Ling Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways

(2008) Kyoko Arimoto et al.   NATURE CELL BIOLOGY

Arginine methylation regulates the p53 response

(2008) Martin Jansson et al.   NATURE CELL BIOLOGY