Contribution of the γ-Secretase Subunits to the Formation of Catalytic Pore of Presenilin 1 Protein

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1

(2011) Yu Ohki et al.   EMBO JOURNAL

The crystal structure of GXGD membrane protease FlaK

(2011) Jian Hu et al.   NATURE

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

The Sec translocase

(2010) David J.F. du Plessis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional Analysis of the Transmembrane Domains of Presenilin 1

(2010) Naoto Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of  -Secretase-Mediated Intramembrane Proteolysis

(2010) A. Fukumori et al.   JOURNAL OF NEUROSCIENCE

Participation of Transmembrane Domain 1 of Presenilin 1 in the Catalytic Pore Structure of the  -Secretase

(2010) S. Takagi et al.   JOURNAL OF NEUROSCIENCE

Structural investigation of the C-terminal catalytic fragment of presenilin 1

(2010) S. Sobhanifar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and intrinsic  -secretase activity of presenilin 1

(2010) K. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretase inhibitors and modulators for Alzheimer’s disease treatment

(2009) Taisuke Tomita   Expert Review of Neurotherapeutics

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations

(2009) Eugene Futai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers

(2009) Yuki Imamura et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How intramembrane proteases bury hydrolytic reactions in the membrane

(2009) Elinor Erez et al.   NATURE

Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β42/40 Ratio

(2009) Kengo Uemura et al.   PLoS One

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Chemical Cross-linking Provides a Model of the γ-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1

(2008) Harald Steiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The C-Terminal PAL Motif and Transmembrane Domain 9 of Presenilin 1 Are Involved in the Formation of the Catalytic Pore of the  -Secretase

(2008) C. Sato et al.   JOURNAL OF NEUROSCIENCE

Modulation by Clamping: Kv4 and KChIP Interactions

(2008) KeWei Wang   NEUROCHEMICAL RESEARCH