Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications

High-fidelity probing of the structure and heterogeneity of extracellular vesicles by resonance-enhanced atomic force microscopy infrared spectroscopy

(2019) Sally Yunsun Kim et al.   Nature Protocols

Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibit Endometrial Cancer Cell Proliferation and Migration through Delivery of Exogenous miR-302a

(2019) Xin Li et al.   Stem Cells International

Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration

(2019) Hyerim Kim et al.   Stem Cell Research & Therapy

Extracellular Vesicles from Thyroid Carcinoma: The New Frontier of Liquid Biopsy

(2019) Germana Rappa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1

(2019) Hui Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Manufacturing of human Wharton's jelly stem cells for clinical use: selection of serum is important

(2019) Chiou Mee Kong et al.   CYTOTHERAPY

microRNA‐16‐5p‐containing exosomes derived from bone marrow‐derived mesenchymal stem cells inhibit proliferation, migration, and invasion, while promoting apoptosis of colorectal cancer cells by downregulating ITGA2

(2019) Yan Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9

(2019) Dong-Mei Wu et al.   Molecular Therapy-Nucleic Acids

Comparison of methods to isolate proteins from extracellular vesicles for mass spectrometry-based proteomic analyses

(2019) Prabal Subedi et al.   ANALYTICAL BIOCHEMISTRY

A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy

(2018) Li Huang et al.   CELL TRANSPLANTATION

A Systematic Review and Meta-analysis of Mesenchymal Stem Cell Injections for the Treatment of Perianal Crohn’s Disease

(2018) Amy L. Lightner et al.   DISEASES OF THE COLON & RECTUM

Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial

(2018) Jian Zhang et al.   Gut and Liver

BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

(2018) Lu Chen et al.   MOLECULAR IMMUNOLOGY

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

(2018) Yufang Shi et al.   Nature Reviews Nephrology

The microRNA regulatory landscape of MSC-derived exosomes: a systems view

(2018) Scott W. Ferguson et al.   Scientific Reports

Comprehensive characterization of chorionic villi-derived mesenchymal stromal cells from human placenta

(2018) Mónica S. Ventura Ferreira et al.   Stem Cell Research & Therapy

The Immunosuppressive Effect of Mesenchymal Stromal Cells on B Lymphocytes is Mediated by Membrane Vesicles

(2018) Manuela Budoni et al.   CELL TRANSPLANTATION

Preconditioning Enhances the Therapeutic Effects of Mesenchymal Stem Cells on Colitis Through PGE2-Mediated T-Cell Modulation

(2018) Fu Yuan Yang et al.   CELL TRANSPLANTATION

Prostaglandin E2 secreted by mesenchymal stem cells protects against acute liver failure via enhancing hepatocyte proliferation

(2018) Yang Liu et al.   FASEB JOURNAL

miRNA-based therapeutic potential of stem cell-derived extracellular vesicles: a safe cell-free treatment to ameliorate radiation-induced brain injury

(2018) Ron J. Leavitt et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Efficient extracellular vesicle isolation by combining cell media modifications, ultrafiltration, and size-exclusion chromatography

(2018) Eduarda M. Guerreiro et al.   PLoS One

Amelioration of clinical symptoms of patients with refractory rheumatoid arthritis following treatment with autologous bone marrow-derived mesenchymal stem cells: A successful clinical trial in Iran

(2018) Mohsen Ghoryani et al.   BIOMEDICINE & PHARMACOTHERAPY

Myths, reality and future of mesenchymal stem cell therapy

(2018) R. A. Poltavtseva et al.   CELL AND TISSUE RESEARCH

Interaction between mesenchymal stromal cell-derived extracellular vesicles and immune cells by distinct protein content

(2018) Soura Mardpour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

(2018) Guanguan Qiu et al.   Stem Cell Research & Therapy

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Dendritic Cell Maturation and Function

(2018) Monica Reis et al.   Frontiers in Immunology

Allogeneic bone marrow-derived mesenchymal stromal cells for hepatitis B virus-related acute-on-chronic liver failure: A randomized controlled trial

(2017) Bing-liang Lin et al.   HEPATOLOGY

Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease

(2017) Ahmed Saad et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mesenchymal stem cells attenuate acute liver injury by altering ratio between interleukin 17 producing and regulatory natural killer T cells

(2017) Neda Milosavljevic et al.   LIVER TRANSPLANTATION

The Emerging Role of Cables1 in Cancer and Other Diseases

(2017) Jia-Rong Huang et al.   MOLECULAR PHARMACOLOGY

Human pluripotent stem cells recurrently acquire and expand dominant negative P53 mutations

(2017) Florian T. Merkle et al.   NATURE

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Immunoaffinity based methods are superior to kits for purification of prostate derived extracellular vesicles from plasma samples

(2017) Sabine I. Brett et al.   PROSTATE

Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

(2017) Sumie Fujii et al.   STEM CELLS

Immune Tolerance of Human Dental Pulp-Derived Mesenchymal Stem Cells Mediated by CD4+CD25+ FoxP3+ Regulatory T-Cells and Induced by TGF-β1 and IL-10

(2017) Jong Won Hong et al.   YONSEI MEDICAL JOURNAL

Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure

(2017) Zhi-heng Zhang et al.   Stem Cell Research & Therapy

Labeling Extracellular Vesicles for Nanoscale Flow Cytometry

(2017) Aizea Morales-Kastresana et al.   Scientific Reports

Vascular complications in diabetes: Microparticles and microparticle associated microRNAs as active players

(2016) Nicoleta Alexandru et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Immunoregulatory Activity of Mesenchymal Stem Cells: ‘State of Art’ and ‘Future Avenues’

(2016) Alessandra Fierabracci et al.   CURRENT MEDICINAL CHEMISTRY

Role of Alix in miRNA packaging during extracellular vesicle biogenesis

(2016) ALESSANDRA IAVELLO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

MicroRNA in Control of Gene Expression: An Overview of Nuclear Functions

(2016) Caterina Catalanotto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MicroRNAs in extracellular vesicles: potential cancer biomarkers

(2016) Takashi Kinoshita et al.   JOURNAL OF HUMAN GENETICS

Human embryonic mesenchymal stem cells alleviate pathologic changes of MRL/Lpr mice by regulating Th7 cell differentiation

(2016) Li Yuan et al.   RENAL FAILURE

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

(2016) Sylwia Koniusz et al.   Frontiers in Cellular Neuroscience

The RNA-Binding Protein SYNCRIP Is a Component of the Hepatocyte Exosomal Machinery Controlling MicroRNA Sorting

(2016) Laura Santangelo et al.   Cell Reports

Mesenchymal Stromal Cells Derived Extracellular Vesicles Ameliorate Acute Renal Ischemia Reperfusion Injury by Inhibition of Mitochondrial Fission through miR-30

(2016) Di Gu et al.   Stem Cells International

Bone marrow stromal/stem cell-derived extracellular vesicles regulate osteoblast activity and differentiation in vitro and promote bone regeneration in vivo

(2016) Yunhao Qin et al.   Scientific Reports

Human Mesenchymal stem cells program macrophage plasticity by altering their metabolic status via a PGE2-dependent mechanism

(2016) Anoop Babu Vasandan et al.   Scientific Reports

Immunoregulatory Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles on T Lymphocytes

(2015) Andrea Del Fattore et al.   CELL TRANSPLANTATION

Recent Advances in Mesenchymal Stem Cell Immunomodulation: The Role of Microvesicles

(2015) Alessandra Fierabracci et al.   CELL TRANSPLANTATION

The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus

(2015) Dandan Wang et al.   Cellular & Molecular Immunology

Mesenchymal-stem-cell-derived exosomes accelerate skeletal muscle regeneration

(2015) Yoshihiro Nakamura et al.   FEBS LETTERS

Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury

(2015) Yanlu Zhang et al.   JOURNAL OF NEUROSURGERY

Mesenchymal stem cell exosomes

(2015) Ruenn Chai Lai et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation

(2015) Patricia Luz-Crawford et al.   STEM CELLS

Mesenchymal Stromal Cells for Treatment of Acute Steroid-Refractory Graft Versus Host Disease: Clinical Responses and Long-Term Outcome

(2015) Felix von Dalowski et al.   STEM CELLS

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

(2015) Krishna C. Vallabhaneni et al.   Oncotarget

Exosomal miR-223 Contributes to Mesenchymal Stem Cell-Elicited Cardioprotection in Polymicrobial Sepsis

(2015) Xiaohong Wang et al.   Scientific Reports

Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression

(2015) Thorsten R. Doeppner et al.   Stem Cells Translational Medicine

Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages

(2014) Giuseppina Turturici et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A review of therapeutic effects of mesenchymal stem cell secretions and induction of secretory modification by different culture methods

(2014) Marialaura Madrigal et al.   Journal of Translational Medicine

Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22

(2014) Yuliang Feng et al.   PLoS One

Microvesicles derived from human Wharton’s Jelly mesenchymal stromal cells ameliorate renal ischemia-reperfusion injury in rats by suppressing CX3CL1

(2014) Xiangyu Zou et al.   Stem Cell Research & Therapy

Extracellular Vesicles as Therapeutic Tools in Cardiovascular Diseases

(2014) Audrey Fleury et al.   Frontiers in Immunology

Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions

(2013) Arsen O Batagov et al.   Biology Direct

Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation

(2013) Friederike Gieseke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2

(2013) Hyung–Sik Kim et al.   GASTROENTEROLOGY

Systemic Administration of Exosomes Released from Mesenchymal Stromal Cells Promote Functional Recovery and Neurovascular Plasticity After Stroke in Rats

(2013) Hongqi Xin et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative proteomics of fractionated membrane and lumen exosome proteins from isogenic metastatic and nonmetastatic bladder cancer cells reveal differential expression of EMT factors

(2013) Dennis Kjølhede Jeppesen et al.   PROTEOMICS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Met degradation: more than one stone to shoot a receptor down

(2012) Jonathan Lefebvre et al.   FASEB JOURNAL

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Transplantation of Placenta-Derived Mesenchymal Stem Cells in the EAE Mouse Model of MS

(2012) Yonit Fisher-Shoval et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions

(2012) Esther N. M. Nolte-’t Hoen et al.   NUCLEIC ACIDS RESEARCH

Safety of Cell Therapy with Mesenchymal Stromal Cells (SafeCell): A Systematic Review and Meta-Analysis of Clinical Trials

(2012) Manoj M. Lalu et al.   PLoS One

Argonaute 2 Complexes Selectively Protect the Circulating MicroRNAs in Cell-Secreted Microvesicles

(2012) Limin Li et al.   PLoS One

The role of tetraspanins in fusion

(2011) Marzieh Fanaei et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF- B signaling in resident macrophages

(2011) H. Choi et al.   BLOOD

Leukemia Inhibitory Factor Inhibits T Helper 17 Cell Differentiation and Confers Treatment Effects of Neural Progenitor Cell Therapy in Autoimmune Disease

(2011) Wei Cao et al.   IMMUNITY

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

(2011) Han-Soo Kim et al.   JOURNAL OF PROTEOME RESEARCH

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

(2011) María Mittelbrunn et al.   Nature Communications

Human multipotent mesenchymal stromal cells use galectin-1 to inhibit immune effector cells

(2010) F. Gieseke et al.   BLOOD

Human breast milk is a rich source of multipotent mesenchymal stem cells

(2010) Satish PATKI et al.   Human Cell

Angiomyeloproliferative Lesions Following Autologous Stem Cell Therapy

(2010) D. Thirabanjasak et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

(2009) Moutih Rafei et al.   JOURNAL OF IMMUNOLOGY

Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity

(2009) Derrick J. Gibbings et al.   NATURE CELL BIOLOGY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Donor-Derived Brain Tumor Following Neural Stem Cell Transplantation in an Ataxia Telangiectasia Patient

(2009) Ninette Amariglio et al.   PLOS MEDICINE

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

Leukemia inhibitory factor: Role in human mesenchymal stem cells mediated immunosuppression

(2008) Aisha Nasef et al.   CELLULAR IMMUNOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE