Review
Endocrinology & Metabolism
Jialin Fu, Marc Gregory Yu, Qian Li, Kyoungmin Park, George L. King
Summary: This review provides a comprehensive summary of insulin's physiological and pathophysiological actions, as well as the associated signaling pathways in vascular cells, particularly in endothelial cells and vascular smooth muscle cells. Insulin plays important roles in regulating nutrient transport and communication in vascular cells through its receptors and signaling cascades, affecting systemic fuel metabolism and energetics. Targeted therapies to improve selective insulin resistance in endothelial cells and vascular smooth muscle cells are necessary to mitigate pathological processes such as endothelial dysfunction, atherosclerosis, and myocardial dysfunction.
MOLECULAR METABOLISM
(2021)
Review
Medicine, General & Internal
Theano Penlioglou, Anca Pantea Stoian, Nikolaos Papanas
Summary: The review summarizes the latest data on the relationship between diabetes mellitus and stroke, including risk factors, prevention, and biomarkers. Progress has been made in prevention and early diagnosis, but there are still crucial points that remain controversial and need further clarification.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yongxia Lu, Wei Wang, Jingyu Liu, Min Xie, Qiang Liu, Sufang Li
Summary: Diabetes mellitus is a complex chronic metabolic disease with hyperglycemia and complications that have long-term negative effects on vital organs. Its global incidence has significantly increased in recent years and is expected to continue rising. Understanding the epidemiology, pathogenesis, risk factors, and treatment of vascular complications is crucial for effective disease management.
Article
Biochemistry & Molecular Biology
Silvia Garavelli, Francesco Prattichizzo, Antonio Ceriello, Mario Galgani, Paola de Candia
Summary: Type 1 diabetes is characterized by autoimmune destruction of insulin-secreting beta cells. Recent research suggests that extracellular vesicles (EVs) may serve as biomarkers and therapeutic targets for disease progression and complications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Multidisciplinary Sciences
Tae-Yeon Kim, Yong-Yeon Song, Il-Jung, Yong-Jin Na, Young-Hoon Lee, Jung-Yeul Kim, Min-Woo Lee
Summary: The study aimed to investigate the effects of prolonged type 2 diabetes (T2DM) on the retinal microvasculature of patients without clinical diabetic retinopathy (DR). The results showed that T2DM patients without DR had decreased vessel densities in both the superficial and deep capillary plexus. The impairment in the deep capillary plexus was more severe in patients with T2DM for more than 10 years. Best corrected visual acuity, hypertension, and duration of diabetes were significant factors associated with the deep vascular density.
Article
Chemistry, Analytical
Ju Yeon Kim, Seok Joon Mun, Yoon Ho Roh, Ki Wan Bong
Summary: miRNAs have been highlighted as potential biomarkers for fatal diseases, and colorimetric bead-based assays are gaining attention for practical miRNA detection due to their simplicity. A rapid colorimetric assay based on hydrogel microparticles was presented, showing decreased reaction time and maintained sensitivity with three different miRNA targets. The method was also validated as suitable for multiplex miRNA detection with low cross-reactivity.
Article
Multidisciplinary Sciences
Margaret B. Fish, Alison L. Banka, Margaret Braunreuther, Catherine A. Fromen, William J. Kelley, Jonathan Lee, Reheman Adili, Michael Holinstat, Omolola Eniola-Adefeso
Summary: The localization and adhesion of vascular-targeted drug carriers to the diseased endothelium are crucial for clinical utility. The physical properties, such as particle size and modulus, play a significant role in determining the efficacy of particle margination and transport to the vascular wall. Deformable hydrogel microparticles have been shown to enhance the delivery of nanoparticles to the vessel wall, demonstrating the importance of optimizing microparticles for efficient margination.
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Parkinson's disease (PD) and Diabetes Mellitus (DM) have been shown to have a connection in recent studies. This link has been discussed in the literature in relation to different mechanisms. miRNAs play a crucial role in regulating insulin pathways, glucose absorption, and PD-related genes, making them a potential therapeutic target for both diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Priyal Dhawan, Sampara Vasishta, Aswath Balakrishnan, Manjunath B. Joshi
Summary: This review provides a comprehensive overview of how hyperglycemia in T2D reprograms endothelial epigenome and leads to vascular complications. It also discusses potential epidrugs that may ameliorate endothelial functions during T2D.
Article
Endocrinology & Metabolism
Ward Fickweiler, Emily A. Wolfson, Samantha M. Paniagua, Marc Gregory Yu, Atif Adam, Vanessa Bahnam, Konstantina Sampani, I-Hsien Wu, Gail Musen, Lloyd P. Aiello, Hetal Shah, Jennifer K. Sun, George L. King
Summary: This study found that decreased vessel density in the retina was associated with cognitive impairment in type 1 diabetes patients. Thinning of the retinal outer nuclear layer was linked to worse psychomotor speed, and outer plexiform layer thickness was associated with delayed memory. These findings suggest that noninvasive retinal imaging using OCT and OCTA may help estimate the risks for cognitive dysfunction in people with type 1 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Pharmacology & Pharmacy
Judy S. Y. Choi, Judy B. de Haan, Arpeeta Sharma
Summary: Diabetes is a chronic metabolic disorder with accelerated development of vascular complications, causing related morbidity and mortality. Current research on diabetes-driven vascular complications relies on animal models to study cellular and molecular pathways. Selecting appropriate animal models is crucial in identifying innovative and mechanism-based targeted therapies for diabetic complications.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Elena Flowers, Bradley E. Aouizerat, Alka M. Kanaya, Jose C. Florez, Xingyue Gong, Li Zhang
Summary: This study identified 5 miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that can effectively predict the incidence of type 2 diabetes. After adjusting for covariates, the HR for the highest quartile risk group compared with the lowest quartile risk group was 5.91. There was significant interaction between the intensive lifestyle and metformin groups compared with placebo. These findings may have potential clinical utility for risk stratification of individuals with prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Anna Birukov, Elli Polemiti, Susanne Jaeger, Norbert Stefan, Matthias B. Schulze
Summary: This study suggests that lower plasma fetuin-A levels measured prior to diabetes diagnosis may be associated with the development of diabetes-associated microvascular disease.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. R. Jacobs Jr, Michael Patrick Bancks, Cora E. E. Lewis, EunSeok Cha, Fengxia Yan, Mercedes R. R. Carnethon, Pamela J. J. Schreiner, Daniel A. A. Duprez
Summary: The study found that the American Heart Association's cardiovascular health (CVH) score is closely associated with early-onset diabetes, later-onset diabetes, and subsequent complications of diabetes. Higher CVH score is associated with lower risk of both early- and later-onset diabetes, as well as diabetic complications. This study highlights the importance of maintaining good cardiovascular health in preventing diabetes and its complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Oncology
Xu-Lan Wang, Wei Zhang, Zhe Li, Wen-Qi Han, Hao-Yu Wu, Qun-Rang Wang, Xin-Hong Liu, Kun Xing, Gong Cheng, Feng-Jun Chang
Summary: The study compared the content and function of circulating microparticles (MPs) from patients with ACS with or without T2DM, revealing that T2DM not only increased MP content but also exacerbated vascular impairment effects in ACS patients. These findings may offer novel insights for the treatment of patients with ACS and T2DM.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Marek T. Tomala, Aleksander Trabka-Zawicki, Andrzej Machnik, Bartlomiej A. Nawrotek, Wojciech Zajdel, Ewa L. Stepien, Jacek Legutko, Krzysztof Zmudka
Summary: This study evaluated the efficacy of ticagrelor in comatose survivors of out-of-hospital cardiac arrest treated with therapeutic hypothermia. The results showed that therapeutic hypothermia did not affect the platelet-inhibitory effect of ticagrelor and did not increase the risk of stent thrombosis.
CARDIOLOGY JOURNAL
(2023)
Review
Endocrinology & Metabolism
Nicoleta Alexandru, Anastasia Procopciuc, Alexandra Vilcu, Ioana Karla Comarita, Elisabeta Badila, Adriana Georgescu
Summary: Extracellular vesicles (EVs) are small anuclear vesicles surrounded by a lipid bilayer, released by various cell types to transfer biologically active molecules like microRNAs to adjacent or distant cells, impacting their phenotype and function. EVs are implicated in the risk and progression of type 2 diabetes mellitus (T2DM), but little is known about their involvement in prediabetes states and associated complications.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Article
Chemistry, Multidisciplinary
Thais S. M. Lima, Wanderson Souza, Luths R. O. Geaquinto, Priscila L. Sanches, Ewa L. Stepien, Joao Meneses, Eli Fernandez-de Gortari, Nicole Meisner-Kober, Martin Himly, Jose M. Granjeiro, Ana R. Ribeiro
Summary: The increasing use of nanomaterials has raised concerns about nanosafety and their potential toxic effects on human health. Studies have shown that nanomaterials can alter cell communication by reshaping and altering the secretion of extracellular vesicles (EVs), leading to dysfunction in recipient cells. However, our understanding of how the physicochemical characteristics of nanomaterials affect EV content and their physiological functions is limited. This review explores the relevance of EVs in the field of nanotoxicology and assesses the modulation of EVs by nanomaterial exposure and the regulation of signaling pathways and physiological responses.
Article
Pharmacology & Pharmacy
Alexandru Filippi, Alina Constantin, Nicoleta Alexandru, Cristina Ana Mocanu, Mihaela Loredana Vlad, Ioana Madalina Fenyo, Agneta Simionescu, Dan Teodor Simionescu, Ileana Manduteanu, Adriana Georgescu
Summary: The number and function of endothelial progenitor cells (EPCs) are reduced in diabetes. Genetically modified EPCs can be a safe treatment option for dyslipidemia and diabetes, preserving aortic valve function.
Article
Biochemistry & Molecular Biology
Magdalena E. Marzec, Carina Rzaca, Pawel Moskal, Ewa L. Stepien
Summary: Time-of-flight secondary ion mass spectrometry (TOF-SIMS) with the Bi3thorn liquid metal ion gun was used to investigate the content of lipids and amino acids in extracellular vesicles. The study confirmed the detrimental effect of hyperglycemia on lipids and amino acids in released extracellular vesicles.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Anna Drozdz, Tomasz Kolodziej, Sonia Wrobel, Krzysztof Misztal, Marta Targosz-Korecka, Marek Drab, Robert Jach, Carina Rzaca, Magdalena Surman, Malgorzata Przybylo, Zenon Rajfur, Ewa L. Stepien
Summary: Extracellular vesicles, particularly LEVs, are important in intercellular communication. This study investigates the changes in human umbilical vein endothelial cells (HUVECs) under high glucose conditions (HGC) and the effects of LEVs released by endothelial cells on HUVECs. The findings reveal the impact of HGC on HUVEC shape, mobility, and metabolic pathways, and the ability of LEVs to activate gene expression related to protein synthesis and vesicle trafficking in HUVECs.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Barbara Zapala, Agnieszka Kaminska, Monika Piwowar, Agnieszka Paziewska, Agnieszka Gala-Bladzinska, Ewa L. Stepien
Summary: This study investigated the role of urine-derived extracellular vesicles (uEVs) in diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM), identifying specific miRNAs that are enriched or downregulated in T2DM patients with DKD. These miRNAs are involved in cellular processes such as apoptosis, inflammation, and tissue remodeling, and further experimental studies are needed to confirm these findings.
PHARMACEUTICAL RESEARCH
(2023)
Review
Physics, Multidisciplinary
Steven D. Bass, Sebastiano Mariazzi, Pawel Moskal, Ewa Stepien
Summary: Positronium, composed of an electron and a positron, reveals valuable insights into quantum electrodynamics (QED) and the structure and processes of biological materials at the nanoscale. Spectroscopic measurements help refine our understanding of QED bound state theory, while studying rare decays and the effect of gravitation on positronium aids in the search for new physics phenomena. In biological materials, positronium decays provide information about intermolecular and intramolecular structure, as well as the metabolism of living organisms. This opens up possibilities for positronium imaging in medicine, particularly in positron emission tomography (PET), where positronium atoms are produced during annihilation inside the patient's body. Advanced PET systems offer potential clinical applications of positronium as a biomarker for tissue pathology and oxidation level.
REVIEWS OF MODERN PHYSICS
(2023)
Review
Polymer Science
Alexandru Scafa Udriste, Adelina-Gabriela Niculescu, Luminita Iliuta, Teodor Bajeu, Adriana Georgescu, Alexandru Mihai Grumezescu, Elisabeta Badila
Summary: Cardiovascular diseases are a major cause of illness and death globally, resulting in significant health and economic burden. The limited regeneration capacity of adult cardiac tissues and lack of therapeutic options are the main reasons for this phenomenon. Recent interdisciplinary research has focused on biomaterial-based approaches to repair and restore heart tissues, utilizing advancements in chemistry, biology, material science, medicine, and nanotechnology. This paper aims to present the advantages of these approaches, such as cardiac patches, injectable hydrogels, extracellular vesicles, and scaffolds, and reviews the latest developments in these fields.
Review
Biochemistry & Molecular Biology
Elisabeta Badila, Cristina Japie, Ana-Maria Vrabie, Adrian Badila, Adriana Georgescu
Summary: Cardiovascular disease and cancer remain significant causes of morbidity and mortality globally. The prevention and treatment of heart disease in cancer patients present ongoing challenges for improving their quality of life and survival. Limited progress has been made in early detection of cardiovascular disease in cancer patients, highlighting the importance of understanding the molecular mechanisms and disease-specific biomarkers in the communication between cancer and cardiovascular disease. Research on extracellular vesicles (EVs) as mediators of this cross talk is still in its early stages. Investigating EV-based biomarkers and therapies may provide insights into responsible mechanisms, early detection of cardiovascular damage, and new therapeutic approaches. The ultimate goal is to reduce the burden of cardiovascular diseases in oncological patients receiving anticancer drugs or radiotherapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Pawel Moskal, Ewelina Kubicz, Grzegorz Grudzien, Eryk Czerwinski, Kamil Dulski, Bartosz Leszczynski, Szymon Niedzwiecki, Ewa L. Stepien
Summary: A new imaging method called ortho-Positronium (o-Ps) imaging was proposed to determine cardiac myxoma by detecting the o-Ps atom generated in the patient's body. The study found that the o-Ps lifetime in myxoma tissue was significantly shorter compared to normal tissue. This method provides a new quantitative approach for in vivo assessment of intracardiac masses on a molecular (nanoscale) level in cardiovascular imaging.
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Sharma, J. Baran, N. Chug, C. Curceanu, E. Czerwinski, M. Dadgar, K. Dulski, K. Eliyan, A. Gajos, N. Gupta-Sharma, B. C. Hiesmayr, K. Kacprzak, L. Kaplon, K. Klimaszewski, P. Konieczka, G. Korcyl, T. Kozik, W. Krzemien, D. Kumar, Sz. Niedzwiecki, D. Panek, S. Parzych, E. Perez del Rio, L. Raczynski, Shivani Choudhary, R. Y. Shopa, M. Skurzok, E. L. Stepien, F. Tayefi, K. Tayefi, W. Wislicki, P. Moskal
Summary: This study aims to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. The experimental results show that the registration efficiency of the J-PET scanner varies between 20% and 100% in the energy deposition range of 70-270 keV.
Review
Medicine, General & Internal
Ewa L. Stepien, Martyna Durak-Kozica, Pawel Moskal
Summary: Extracellular vesicles (EVs) are released by all cells, both in physiological and pathological conditions. Their molecular charge and composition emerge as possible biomarkers, but EVs may also be considered for other clinical applications. This review discusses the role of other features of EVs, such as their lipid components or composition of glycans that form the EV corona and regulate EV biodistribution and uptake by target cells. The importance of EV electric charge has been discussed as a new insight into EV fate and destination.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2023)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)