A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3

DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages

(2018) Yimin Lao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics

(2018) Chunmei Chang et al.   MOLECULAR CELL

Making the connections: Autophagy and post-translational modifications in cardiomyocytes

(2016) Manish K. Gupta et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

UBC9-Mediated Sumoylation Favorably Impacts Cardiac Function in Compromised HeartsNovelty and Significance

(2016) Manish K. Gupta et al.   CIRCULATION RESEARCH

SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer

(2016) Z Zhou et al.   ONCOGENE

Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon

(2015) Daichao Xu et al.   Autophagy

mTOR: a pharmacologic target for autophagy regulation

(2015) Young Chul Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

ATM functions at the peroxisome to induce pexophagy in response to ROS

(2015) Jiangwei Zhang et al.   NATURE CELL BIOLOGY

Neddylation controls basal MKK7 kinase activity in breast cancer cells

(2015) T Zhu et al.   ONCOGENE

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth

(2015) Ting Sun et al.   Nature Communications

SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation

(2015) Ming Wang et al.   Protein & Cell

SUMO1 promotes Aβ production via the modulation of autophagy

(2014) Sun-Jung Cho et al.   Autophagy

Posttranslational modification of autophagy-related proteins in macroautophagy

(2014) Yangchun Xie et al.   Autophagy

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Regulation of autophagy by protein post-translational modification

(2014) Willayat Yousuf Wani et al.   LABORATORY INVESTIGATION

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

(2014) E.A. Dunlop et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia

(2013) Chun Guo et al.   EMBO JOURNAL

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

HyPer-3: A Genetically Encoded H2O2 Probe with Improved Performance for Ratiometric and Fluorescence Lifetime Imaging

(2012) Dmitry S. Bilan et al.   ACS Chemical Biology

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

Self-eating with your fingers

(2012) Daniel J Klionsky et al.   CELL RESEARCH

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

(2012) Weijiao Huang et al.   CELL RESEARCH

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation

(2012) Lin Li et al.   CELLULAR SIGNALLING

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Impaired autophagy due to constitutive mTOR activation sensitizes TSC2-null cells to cell death under stress

(2011) Shukie Ng et al.   Autophagy

Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1

(2011) Harald W. Platta et al.   BIOCHEMICAL JOURNAL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Autophagy: for better or for worse

(2011) Ellen Wirawan et al.   CELL RESEARCH

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

(2011) David G. McEwan et al.   TRENDS IN CELL BIOLOGY

UVRAGmutations associated with microsatellite unstable colon cancer do not affect autophagy

(2010) Helene Knævelsrud et al.   Autophagy

Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

(2010) Shan Yan et al.   EMBO JOURNAL

SENP3-mediated De-conjugation of SUMO2/3 from Promyelocytic Leukemia Is Correlated with Accelerated Cell Proliferation under Mild Oxidative Stress

(2010) Yan Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Negative Regulation of Vps34 by Cdk Mediated Phosphorylation

(2010) Tsuyoshi Furuya et al.   MOLECULAR CELL

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Superoxide is the major reactive oxygen species regulating autophagy

(2009) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation

(2009) Chao Huang et al.   EMBO JOURNAL

DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy

(2009) Einat Zalckvar et al.   EMBO REPORTS

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1–phosphatidylinositol-3-kinase complex

(2009) Yun Zhong et al.   NATURE CELL BIOLOGY

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

(2009) Kohichi Matsunaga et al.   NATURE CELL BIOLOGY

Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment

(2008) Meghan B. Azad et al.   ANTIOXIDANTS & REDOX SIGNALING

The regulation and function of Class III PI3Ks: novel roles for Vps34

(2008) Jonathan M. Backer   BIOCHEMICAL JOURNAL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA