Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats

Stress, cell senescence and organismal ageing

(2018) João Pedro de Magalhães et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Comparative metabolomics of aging in a long-lived bat: Insights into the physiology of extreme longevity

(2018) Hope C. Ball et al.   PLoS One

Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly

(2018) Peer Aramillo Irizar et al.   Nature Communications

Bat Biology, Genomes, and the Bat1K Project: To Generate Chromosome-Level Genomes for All Living Bat Species

(2018) Emma C. Teeling et al.   Annual Review of Animal Biosciences

Is there a link between aging and microbiome diversity in exceptional mammalian longevity?

(2018) Graham M. Hughes et al.   PeerJ

Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity

(2018) Nicole M. Foley et al.   Science Advances

Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the Free Radical Theory of Ageing

(2018) David Jebb et al.   Scientific Reports

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Human Ageing Genomic Resources: new and updated databases

(2017) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species

(2017) Xiao Tian et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes

(2016) Vadim N. Gladyshev   AGING CELL

variancePartition: interpreting drivers of variation in complex gene expression studies

(2016) Gabriel E. Hoffman et al.   BMC BIOINFORMATICS

Blood miRNomes and transcriptomes reveal novel longevity mechanisms in the long-lived bat, Myotis myotis

(2016) Zixia Huang et al.   BMC GENOMICS

Pervasive Effects of Aging on Gene Expression in Wild Wolves

(2016) Pauline Charruau et al.   MOLECULAR BIOLOGY AND EVOLUTION

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

(2016) Mohammad A. Jafri et al.   Genome Medicine

Cell cycle arrest is not senescence

(2016) Mikhail V. Blagosklonny   Aging-US

Gene expression defines natural changes in mammalian lifespan

(2015) Alexey A. Fushan et al.   AGING CELL

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

A nonlethal sampling method to obtain, generate and assemble whole blood transcriptomes from small, wild mammals

(2015) Zixia Huang et al.   Molecular Ecology Resources

The Pfam protein families database: towards a more sustainable future

(2015) Robert D. Finn et al.   NUCLEIC ACIDS RESEARCH

The human transcriptome across tissues and individuals

(2015) M. Mele et al.   SCIENCE

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

miR-146a functions as a tumor suppressor in prostate cancer by targeting Rac1

(2014) Qian Sun et al.   PROSTATE

The Scientific Quest for Lasting Youth: Prospects for Curing Aging

(2014) João Pedro de Magalhães   REJUVENATION RESEARCH

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Molecular phylogenetic reconstructions identify East Asia as the cradle for the evolution of the cosmopolitan genus Myotis (Mammalia, Chiroptera)

(2013) Manuel Ruedi et al.   MOLECULAR PHYLOGENETICS AND EVOLUTION

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

(2013) Brian J Haas et al.   Nature Protocols

CPAT: Coding-Potential Assessment Tool using an alignment-free logistic regression model

(2013) Liguo Wang et al.   NUCLEIC ACIDS RESEARCH

Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii

(2013) Inge Seim et al.   Nature Communications

TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions

(2013) Daehwan Kim et al.   GENOME BIOLOGY

Genetics of Longevity in Model Organisms: Debates and Paradigm Shifts

(2012) David Gems et al.   Annual Review of Physiology

Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity

(2012) Ana Ortega-Molina et al.   Cell Metabolism

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

(2012) Darren J. Baker et al.   NATURE CELL BIOLOGY

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

FastUniq: A Fast De Novo Duplicates Removal Tool for Paired Short Reads

(2012) Haibin Xu et al.   PLoS One

PTEN in cancer, metabolism, and aging

(2012) Ana Ortega-Molina et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Accelerated protein evolution analysis reveals genes and pathways associated with the evolution of mammalian longevity

(2011) Yang Li et al.   AGE

Genome sequencing reveals insights into physiology and longevity of the naked mole rat

(2011) Eun Bae Kim et al.   NATURE

miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades

(2011) Marc R. Friedländer et al.   NUCLEIC ACIDS RESEARCH

Mass extinctions, biodiversity and mitochondrial function: are bats ‘special’ as reservoirs for emerging viruses?

(2011) Lin-Fa Wang et al.   Current Opinion in Virology

FrameDP: sensitive peptide detection on noisy matured sequences

(2009) J. Gouzy et al.   BIOINFORMATICS

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Methusaleh's Zoo: How Nature provides us with Clues for Extending Human Health Span

(2009) S.N. Austad   JOURNAL OF COMPARATIVE PATHOLOGY

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS