NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

RelB-Deficient Dendritic Cells Promote the Development of Spontaneous Allergic Airway Inflammation

(2018) Prema M. Nair et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses

(2018) Gaetan Barbet et al.   IMMUNITY

Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression

(2018) Kyu-Seon Oh et al.   JOURNAL OF IMMUNOLOGY

Variation in Genome-Wide NF-κB RELA Binding Sites upon Microbial Stimuli and Identification of a Virus Response Profile

(2018) Lisa Borghini et al.   JOURNAL OF IMMUNOLOGY

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

(2018) James Bagnall et al.   Science Signaling

NEMO–IKKβ Are Essential for IRF3 and NF-κB Activation in the cGAS–STING Pathway

(2017) Run Fang et al.   JOURNAL OF IMMUNOLOGY

The archaic roles of the lamprey NF-κB (lj-NF-κB) in innate immune responses

(2017) Peng Su et al.   MOLECULAR IMMUNOLOGY

Cellular Decision Making by Non-Integrative Processing of TLR Inputs

(2017) Ryan A. Kellogg et al.   Cell Reports

Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages

(2017) Bin Lin et al.   Cell Systems

Measuring Signaling and RNA-Seq in the Same Cell Links Gene Expression to Dynamic Patterns of NF-κB Activation

(2017) Keara Lane et al.   Cell Systems

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

(2017) Jiro Sakai et al.   Scientific Reports

Infection in an aging population

(2016) Kimberly A Kline et al.   CURRENT OPINION IN MICROBIOLOGY

The RelA/cRel nuclear factor-κB (NF-κB) dimer, crucial for inflammation resolution, mediates the transcription of the key enzyme in melatonin synthesis in RAW 264.7 macrophages

(2016) Sandra Marcia Muxel et al.   JOURNAL OF PINEAL RESEARCH

Noncanonical NF-κB Signaling in Health and Disease

(2016) Gökhan Cildir et al.   TRENDS IN MOLECULAR MEDICINE

High-resolution imaging and computational analysis of haematopoietic cell dynamics in vivo

(2016) Claire S. Koechlein et al.   Nature Communications

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

(2016) Alicja Puchta et al.   PLoS Pathogens

NF-κB oscillations translate into functionally related patterns of gene expression

(2016) Samuel Zambrano et al.   eLife

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

(2016) John M Ankers et al.   eLife

Noise Induces Hopping between NF-κB Entrainment Modes

(2016) Mathias Heltberg et al.   Cell Systems

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses

(2016) Rachel A. Gottschalk et al.   Cell Systems

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3–TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response

(2015) Qian Liu et al.   JOURNAL OF IMMUNOLOGY

Single-cell variation leads to population invariance in NF-κB signaling dynamics

(2015) Jacob J. Hughey et al.   MOLECULAR BIOLOGY OF THE CELL

Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition

(2015) Andrea Hodgson et al.   MOLECULAR MICROBIOLOGY

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Digital signaling decouples activation probability and population heterogeneity

(2015) Ryan A Kellogg et al.   eLife

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

High-Sensitivity Measurements of Multiple Kinase Activities in Live Single Cells

(2014) Sergi Regot et al.   CELL

Network dynamics determine the autocrine and paracrine signaling functions of TNF

(2014) Andrew B. Caldwell et al.   GENES & DEVELOPMENT

Differential Requirement for the IKKβ/NF-κB Signaling Module in Regulating TLR- versus RLR-Induced Type 1 IFN Expression in Dendritic Cells

(2014) Xingyu Wang et al.   JOURNAL OF IMMUNOLOGY

Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3

(2014) Z. Xiang et al.   JOURNAL OF VIROLOGY

NF-κB Directs Dynamic Super Enhancer Formation in Inflammation and Atherogenesis

(2014) Jonathan D. Brown et al.   MOLECULAR CELL

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells

(2014) Robin E.C. Lee et al.   MOLECULAR CELL

High-Throughput Analysis of NF-κB Dynamics in Single Cells Reveals Basal Nuclear Localization of NF-κB and Spontaneous Activation of Oscillations

(2014) Samuel Zambrano et al.   PLoS One

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

The synergy in cytokine production through MyD88-TRIF pathways is co-ordinated with ERK phosphorylation in macrophages

(2013) Rebecca Suet Ting Tan et al.   IMMUNOLOGY AND CELL BIOLOGY

Cell Death Triggered by Yersinia enterocolitica Identifies Processing of the Proinflammatory Signal Adapter MyD88 as a General Event in the Execution of Apoptosis

(2013) L. Novikova et al.   JOURNAL OF IMMUNOLOGY

The Deubiquitinase A20 Mediates Feedback Inhibition of Interleukin-17 Receptor Signaling

(2013) A. V. Garg et al.   Science Signaling

NF-κB function in B lymphocytes

(2012) Mary Kaileh et al.   IMMUNOLOGICAL REVIEWS

Regulation of NF-κB by ubiquitination and degradation of the IκBs

(2012) Naama Kanarek et al.   IMMUNOLOGICAL REVIEWS

Lessons from mathematically modeling the NF-κB pathway

(2012) Soumen Basak et al.   IMMUNOLOGICAL REVIEWS

Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis

(2012) Emilie Courtine et al.   Innate Immunity

NEMO Ensures Signaling Specificity of the Pleiotropic IKKβ by Directing Its Kinase Activity toward IκBα

(2012) Bärbel Schröfelbauer et al.   MOLECULAR CELL

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways

(2012) Vincent F-S Shih et al.   NATURE IMMUNOLOGY

Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue

(2011) Pernille Yde et al.   BMC Systems Biology

Mathematical modeling and sensitivity analysis of the integrated TNFα-mediated apoptotic pathway for identifying key regulators

(2011) Geoffrey Koh et al.   COMPUTERS IN BIOLOGY AND MEDICINE

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Detection of prokaryotic mRNA signifies microbial viability and promotes immunity

(2011) Leif E. Sander et al.   NATURE

Computational modeling with forward and reverse engineering links signaling network and genomic regulatory responses: NF-κB signaling-induced gene expression responses in inflammation

(2010) Shih Peng et al.   BMC BIOINFORMATICS

Selection of a muramyl peptide based on its lack of activation of nuclear factor-κB as a potential adjuvant for AIDS vaccines

(2010) R. SCHRECK et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

(2010) Savaş Tay et al.   NATURE

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens

Toll-like receptors and innate immunity

(2009) Himanshu Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Control of Inducible Gene Expression by Signal-Dependent Transcriptional Elongation

(2009) Diana C. Hargreaves et al.   CELL

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

The Nfkb1 and Nfkb2 Proteins p105 and p100 Function as the Core of High-Molecular-Weight Heterogeneous Complexes

(2009) Olga V. Savinova et al.   MOLECULAR CELL

Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

(2009) Vladimir Litvak et al.   NATURE IMMUNOLOGY

Sustained Oscillations of NF-κB Produce Distinct Genome Scanning and Gene Expression Profiles

(2009) Myong-Hee Sung et al.   PLoS One

Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

(2009) L. Ashall et al.   SCIENCE

A Noisy Paracrine Signal Determines the Cellular NF- B Response to Lipopolysaccharide

(2009) T. K. Lee et al.   Science Signaling

NF- B in the Immune Response of Drosophila

(2009) C. Hetru et al.   Cold Spring Harbor Perspectives in Biology

Encoding NF- B temporal control in response to TNF: distinct roles for the negative regulators I B  and A20

(2008) S. L. Werner et al.   GENES & DEVELOPMENT

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

(2008) Brian J Zarnegar et al.   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY