Quantitative analysis of competitive cytokine signaling predicts tissue thresholds for the propagation of macrophage activation

Circuit Design Features of a Stable Two-Cell System

(2018) Xu Zhou et al.   CELL

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

(2017) Alon Oyler-Yaniv et al.   IMMUNITY

Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells

(2017) Ruth Brignall et al.   JOURNAL OF IMMUNOLOGY

An intelligentized strategy for endogenous small molecules characterization and quality evaluation of earthworm from two geographic origins by ultra-high performance HILIC/QTOF MSE and Progenesis QI

(2016) Jingxian Zhang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation

(2016) Ann-Jay Tong et al.   CELL

Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states

(2016) Antony Adamson et al.   Nature Communications

High-Content Quantification of Single-Cell Immune Dynamics

(2016) Michael Junkin et al.   Cell Reports

Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

(2016) John M Ankers et al.   eLife

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses

(2016) Rachel A. Gottschalk et al.   Cell Systems

Noise Facilitates Transcriptional Control under Dynamic Inputs

(2015) Ryan A. Kellogg et al.   CELL

Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer

(2015) J. Bagnall et al.   Integrative Biology

Automated co-culture system for spatiotemporal analysis of cell-to-cell communication

(2015) Tino Frank et al.   LAB ON A CHIP

Single-cell variation leads to population invariance in NF-κB signaling dynamics

(2015) Jacob J. Hughey et al.   MOLECULAR BIOLOGY OF THE CELL

Single Mammalian Cells Compensate for Differences in Cellular Volume and DNA Copy Number through Independent Global Transcriptional Mechanisms

(2015) Olivia Padovan-Merhar et al.   MOLECULAR CELL

Toll-like receptor signalling through macromolecular protein complexes

(2015) Clare E. Bryant et al.   MOLECULAR IMMUNOLOGY

Highly multiplexed profiling of single-cell effector functions reveals deep functional heterogeneity in response to pathogenic ligands

(2015) Yao Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation

(2015) Qiong Xue et al.   Science Signaling

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Three-Dimensional Gradients of Cytokine Signaling between T Cells

(2015) Kevin Thurley et al.   PLoS Computational Biology

Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation

(2015) Qiong Xue et al.   Science Signaling

Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation

(2015) Zhang Cheng et al.   Science Signaling

Sending Mixed Messages for Cell Population Control

(2014) Hyun Youk et al.   CELL

Network dynamics determine the autocrine and paracrine signaling functions of TNF

(2014) Andrew B. Caldwell et al.   GENES & DEVELOPMENT

Origin and Functions of Tissue Macrophages

(2014) Slava Epelman et al.   IMMUNITY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex

(2014) H. Fujita et al.   MOLECULAR AND CELLULAR BIOLOGY

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells

(2014) Robin E.C. Lee et al.   MOLECULAR CELL

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Noise decomposition of intracellular biochemical signaling networks using nonequivalent reporters

(2014) Alex Rhee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accurate information transmission through dynamic biochemical signaling networks

(2014) J. Selimkhanov et al.   SCIENCE

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

Homeostasis in the mononuclear phagocyte system

(2014) Stephen J. Jenkins et al.   TRENDS IN IMMUNOLOGY

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

(2014) Karen E Tkach et al.   eLife

A Transcriptomic Network Identified in Uninfected Macrophages Responding to Inflammation Controls Intracellular Pathogen Survival

(2013) Lynette Beattie et al.   Cell Host & Microbe

FISH-quant: automatic counting of transcripts in 3D FISH images

(2013) Florian Mueller et al.   NATURE METHODS

Spontaneous NF-κB Activation by Autocrine TNFα Signaling: A Computational Analysis

(2013) Jakub Pękalski et al.   PLoS One

NanoStringNorm: an extensible R package for the pre-processing of NanoString mRNA and miRNA data

(2012) Daryl Waggott et al.   BIOINFORMATICS

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

(2012) Kelly Verhelst et al.   EMBO JOURNAL

CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation

(2012) Andreas J. Müller et al.   IMMUNITY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Coordinate Regulation of TPL-2 and NF- B Signaling in Macrophages by NF- B1 p105

(2012) H.-T. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Modeling the NF-κB mediated inflammatory response predicts cytokine waves in tissue

(2011) Pernille Yde et al.   BMC Systems Biology

A systematic survey of the response of a model NF-κB signalling pathway to TNFα stimulation

(2011) Yunjiao Wang et al.   JOURNAL OF THEORETICAL BIOLOGY

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Single-cell NF-κB dynamics reveal digital activation and analogue information processing

(2010) Savaş Tay et al.   NATURE

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Population robustness arising from cellular heterogeneity

(2010) P. Paszek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delineation of Diverse Macrophage Activation Programs in Response to Intracellular Parasites and Cytokines

(2010) Shuyi Zhang et al.   PLoS Neglected Tropical Diseases

A Unifying Model for the Selective Regulation of Inducible Transcription by CpG Islands and Nucleosome Remodeling

(2009) Vladimir R. Ramirez-Carrozzi et al.   CELL

Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network

(2009) Laurent Chorro et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules

(2009) Shengli Hao et al.   NATURE IMMUNOLOGY

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Pulsatile Stimulation Determines Timing and Specificity of NF- B-Dependent Transcription

(2009) L. Ashall et al.   SCIENCE

A Noisy Paracrine Signal Determines the Cellular NF- B Response to Lipopolysaccharide

(2009) T. K. Lee et al.   Science Signaling

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

NF-κB Suppression by the Deubiquitinating Enzyme Cezanne

(2008) Karine Enesa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

(2008) Stefan Schütze et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY