Interference with nuclear factor kappaB signaling pathway by pathogen-encoded proteases: global and selective inhibition

Cutaneous Leishmaniasis: Recent Developments in Diagnosis and Management

(2015) Henry J. C. de Vries et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Vaccines for visceral leishmaniasis: A review

(2015) Keerti Jain et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Metalloprotease NleC Suppresses Host NF-κB/Inflammatory Responses by Cleaving p65 and Interfering with the p65/RPS3 Interaction

(2015) Andrea Hodgson et al.   PLoS Pathogens

The Structure and Specificity of the Type III Secretion System Effector NleC Suggest a DNA Mimicry Mechanism of Substrate Recognition

(2014) Michelle Marian Turco et al.   BIOCHEMISTRY

Krüppel-like Factor 6 Is a Co-activator of NF-κB That Mediates p65-dependent Transcription of Selected Downstream Genes

(2014) Yu Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting the Deubiquitinating Enzymes (DUBs)

(2014) Chudi Ndubaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 4 Antagonizes Beta Interferon Expression by Targeting the NF- B Essential Modulator

(2014) C. Huang et al.   JOURNAL OF VIROLOGY

Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3

(2014) Z. Xiang et al.   JOURNAL OF VIROLOGY

Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

(2014) Qing Yao et al.   PLoS Pathogens

Beyond MyD88 and TRIF Pathways in Toll-Like Receptor Signaling

(2014) Vincent Piras et al.   Frontiers in Immunology

Masters, marionettes and modulators: intersection of pathogen virulence factors and mammalian death receptor signaling

(2013) John Silke et al.   CURRENT OPINION IN IMMUNOLOGY

Escherichia coliVirulence Protein NleH1 Interaction with the v-Crk Sarcoma Virus CT10 Oncogene-like Protein (CRKL) Governs NleH1 Inhibition of the Ribosomal Protein S3 (RPS3)/Nuclear Factor κB (NF-κB) Pathway

(2013) Thanh H. Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death Triggered by Yersinia enterocolitica Identifies Processing of the Proinflammatory Signal Adapter MyD88 as a General Event in the Execution of Apoptosis

(2013) L. Novikova et al.   JOURNAL OF IMMUNOLOGY

Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells

(2013) Kai Fu et al.   Nature Communications

The Apoptogenic Toxin AIP56 Is a Metalloprotease A-B Toxin that Cleaves NF-κb P65

(2013) Daniela S. Silva et al.   PLoS Pathogens

Enteropathogenic and enterohemorrhagic E. coli: ecology, pathogenesis, and evolution

(2013) Elizabeth L. Hartland et al.   Frontiers in Cellular and Infection Microbiology

Structure and mechanism of a type III secretion protease, NleC

(2013) Wenqi Li et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Functional Differences and Interactions between the Escherichia coli Type III Secretion System Effectors NleH1 and NleH2

(2012) Thanh H. Pham et al.   INFECTION AND IMMUNITY

Multiple NF-κB Sites in HIV-1 Subtype C Long Terminal Repeat Confer Superior Magnitude of Transcription and Thereby the Enhanced Viral Predominance

(2012) Mahesh Bachu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of an N-terminal Truncation of the NF-κB p65 Subunit That Specifically Modulates Ribosomal Protein S3-dependent NF-κB Gene Expression

(2012) Eric M. Wier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Host Factor Transcriptional Regulation Contributes to Preferential Expression of HIV Type 1 in IL-4-Producing CD4 T Cells

(2012) M. Zhang et al.   JOURNAL OF IMMUNOLOGY

Cysteine 38 Holds the Key to NF-κB Activation

(2012) Neil D. Perkins   MOLECULAR CELL

Hydrogen Sulfide-Linked Sulfhydration of NF-κB Mediates Its Antiapoptotic Actions

(2012) Nilkantha Sen et al.   MOLECULAR CELL

Expression and Regulation of the Escherichia coli O157:H7 Effector Proteins NleH1 and NleH2

(2012) Ashleigh Holmes et al.   PLoS One

Bacterial effector interplay: a new way to view effector function

(2012) Stephanie R. Shames et al.   TRENDS IN MICROBIOLOGY

Subversion of innate immune responses by bacterial hindrance of NF-κB pathway

(2011) Gaëlle Le Negrate   CELLULAR MICROBIOLOGY

The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300

(2011) Stephanie R. Shames et al.   CELLULAR MICROBIOLOGY

Attaching and Effacing Bacterial Effector NleC Suppresses Epithelial Inflammatory Responses by Inhibiting NF-κB and p38 Mitogen-Activated Protein Kinase Activation

(2011) Ho Pan Sham et al.   INFECTION AND IMMUNITY

Manipulation of kinase signaling by bacterial pathogens

(2011) Anne Marie Krachler et al.   JOURNAL OF CELL BIOLOGY

A type III effector protease NleC from enteropathogenic Escherichia coli targets NF-κB for degradation

(2011) Jaclyn S. Pearson et al.   MOLECULAR MICROBIOLOGY

Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements

(2011) Alexander R. C. Wong et al.   MOLECULAR MICROBIOLOGY

IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7

(2011) Fengyi Wan et al.   NATURE IMMUNOLOGY

Proteolytic Cleavage of NF-κB p65: A Novel Mechanism for Subversion of Innate Immune Signaling by Pathogenic E. Coli

(2011) Stephanie R. Shames et al.   Frontiers in Microbiology

Ribosomal Protein S3: A Multifunctional Target of Attaching/Effacing Bacterial Pathogens

(2011) Xiaofei Gao et al.   Frontiers in Microbiology

Chlamydia Trachomatis Secretion of Proteases for Manipulating Host Signaling Pathways

(2011) Guangming Zhong   Frontiers in Microbiology

Metalloprotease type III effectors that specifically cleave JNK and NF-κB

(2010) Kobi Baruch et al.   EMBO JOURNAL

Cleavage of the NF-κB Family Protein p65/RelA by the Chlamydial Protease-like Activity Factor (CPAF) Impairs Proinflammatory Signaling in Cells Infected with Chlamydiae

(2010) Jan Christian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome-independent Degradation of Canonical NFκB Complex Components by the NleC Protein of PathogenicEscherichia coli

(2010) Sabrina Mühlen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Time-Dependent c-Myc Transactomes Mapped by Array-Based Nuclear Run-On Reveal Transcriptional Modules in Human B Cells

(2010) JinShui Fan et al.   PLoS One

NleC, a Type III Secretion Protease, Compromises NF-κB Activation by Targeting p65/RelA

(2010) Hilo Yen et al.   PLoS Pathogens

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

The nuclear signaling of NF-κB: current knowledge, new insights and future perspectives

(2009) Fengyi Wan et al.   CELL RESEARCH

Nuclear factor-kappa B in intestinal protection and destruction

(2009) Martina E Spehlmann et al.   CURRENT OPINION IN GASTROENTEROLOGY

A Comprehensive Proteomic Analysis of the Type III Secretome ofCitrobacter rodentium

(2009) Wanyin Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virulence factors and their mechanisms of action: the view from a damage–response framework

(2009) Arturo Casadevall et al.   JOURNAL OF WATER AND HEALTH

Targeting of immune signalling networks by bacterial pathogens

(2009) Igor E. Brodsky et al.   NATURE CELL BIOLOGY

Bacterial Effector Binding to Ribosomal Protein S3 Subverts NF-κB Function

(2009) Xiaofei Gao et al.   PLoS Pathogens

A novel form of NF-κB is induced byLeishmaniainfection: Involvement in macrophage gene expression

(2008) David J. Gregory et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes

(2008) Mayte Coiras et al.   Retrovirology