TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

Blockage of TNF-α by Infliximab Reduces CCL2 and CCR2 Levels in Patients With Rheumatoid Arthritis

(2016) Liping Xia et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease

(2015) Vicente F. Corrales-Medina et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Alterations to the Frequency and Function of Peripheral Blood Monocytes and Associations with Chronic Disease in the Advanced-Age, Frail Elderly

(2014) Chris P. Verschoor et al.   PLoS One

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Bidirectional Relationship between Cognitive Function and Pneumonia

(2013) Faraaz Ali Shah et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased frequency of cluster of differentiation 14 (CD14+) monocytes expressing interleukin 1 beta (IL-1β) in Alzheimer's disease patients and intermediate levels in late-onset depression patients

(2013) Karen Cecília Torres et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

(2013) Myriam N. Bouchlaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults

(2013) R. Varadhan et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Intravenous Delivery of HIV-Based Lentiviral Vectors Preferentially Transduces F4/80+ and Ly-6C+ Cells in Spleen, Important Target Cells in Autoimmune Arthritis

(2013) Ben T. van den Brand et al.   PLoS One

Relevance of Distinct Monocyte Subsets to Clinical Course of Ischemic Stroke Patients

(2013) Muichi Kaito et al.   PLoS One

Adalimumab: long-term safety in 23 458 patients from global clinical trials in rheumatoid arthritis, juvenile idiopathic arthritis, ankylosing spondylitis, psoriatic arthritis, psoriasis and Crohn's disease

(2012) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα

(2012) Guangwen Ren et al.   Cell Stem Cell

Aging is associated with circulating cytokine dysregulation

(2012) Lorena Álvarez-Rodríguez et al.   CELLULAR IMMUNOLOGY

Elevated CD14 ++ CD16 − Monocytes Predict Cardiovascular Events

(2012) Katarina E. Berg et al.   Circulation-Cardiovascular Genetics

Dexamethasone Downregulates the Systemic Cytokine Response in Patients with Community-Acquired Pneumonia

(2012) Hilde H. F. Remmelts et al.   Clinical and Vaccine Immunology

Local and systemic cytokine profiles in nonsevere and severe community-acquired pneumonia

(2012) Marthe S. Paats et al.   EUROPEAN RESPIRATORY JOURNAL

Inflammation switches the differentiation program of Ly6Chimonocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon

(2012) Aymeric Rivollier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Biomarkers define the clinical response to dexamethasone in community-acquired pneumonia

(2012) Hilde H.F. Remmelts et al.   JOURNAL OF INFECTION

CD14++CD16+ Monocytes Independently Predict Cardiovascular Events

(2012) Kyrill S. Rogacev et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monocyte populations as markers of response to adalimumab plus MTX in rheumatoid arthritis

(2012) Luis Chara et al.   ARTHRITIS RESEARCH & THERAPY

Inflamm-aging of the stem cell niche: Breast cancer as a paradigmatic example

(2011) Massimiliano Bonafè et al.   BIOESSAYS

Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe −/− mouse model of the metabolic syndrome

(2011) H. G. Martinez et al.   DIABETOLOGIA

The clinical use of adjuvants in pneumococcal vaccination: Current status and future perspectives

(2011) Ole Søgaard   Human vaccines & immunotherapeutics

The Nod2 Sensor Promotes Intestinal Pathogen Eradication via the Chemokine CCL2-Dependent Recruitment of Inflammatory Monocytes

(2011) Yun-Gi Kim et al.   IMMUNITY

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice

(2011) Kimberly M. Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Interleukin-6, C-Reactive Protein, and Tumor Necrosis Factor-Alpha as Predictors of Mortality in Frail, Community-Living Elderly Individuals

(2011) Silvia Giovannini et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Dexamethasone and length of hospital stay in patients with community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial

(2011) Sabine CA Meijvis et al.   LANCET

Therapeutic siRNA silencing in inflammatory monocytes in mice

(2011) Florian Leuschner et al.   NATURE BIOTECHNOLOGY

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

(2010) Sebastian Seidler et al.   BMC IMMUNOLOGY

Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors

(2010) Jérôme Cros et al.   IMMUNITY

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Senescent CD14+CD16+ Monocytes Exhibit Proinflammatory and Proatherosclerotic Activity

(2010) A. Merino et al.   JOURNAL OF IMMUNOLOGY

The influence of pre-existing diabetes mellitus on the host immune response and outcome of pneumonia: analysis of two multicentre cohort studies

(2010) S. Yende et al.   THORAX

Adalimumab safety and mortality rates from global clinical trials of six immune-mediated inflammatory diseases

(2009) G R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease

(2009) I. L. King et al.   BLOOD

Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

(2009) Orestes Vicente Forlenza et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Age‐Associated Inflammation and Toll‐Like Receptor Dysfunction Prime the Lungs for Pneumococcal Pneumonia

(2009) Ernesto Hinojosa et al.   JOURNAL OF INFECTIOUS DISEASES

Age-Associated Increase in Cytokine Production During Systemic Inflammation: Adipose Tissue as a Major Source of IL-6

(2009) M. E. Starr et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands

(2009) Roman Barbalat et al.   NATURE IMMUNOLOGY

Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

(2009) William Whiteley et al.   PLOS MEDICINE

Inflammatory Markers at Hospital Discharge Predict Subsequent Mortality after Pneumonia and Sepsis

(2008) Sachin Yende et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

(2008) R. H. Cho et al.   BLOOD

Gr1+ Inflammatory Monocytes Are Required for Mucosal Resistance to the Pathogen Toxoplasma gondii

(2008) Ildiko R. Dunay et al.   IMMUNITY

Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14+ monocytes in frail older adults

(2008) Tao Qu et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

CD14++CD16+ monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients

(2007) G.H. Heine et al.   KIDNEY INTERNATIONAL