Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential

Size-Based Differentiation of Cancer and Normal Cells by a Particle Size Analyzer Assisted by a Cell-Recognition PC Software

(2018) Babita Shashni et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues

(2018) Aleksandra Karolak et al.   Journal of the Royal Society Interface

Generation of human brain region–specific organoids using a miniaturized spinning bioreactor

(2018) Xuyu Qian et al.   Nature Protocols

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Personalized Cancer Medicine: An Organoid Approach

(2018) Hamidreza Aboulkheyr Es et al.   TRENDS IN BIOTECHNOLOGY

Patient derived organoids to model rare prostate cancer phenotypes

(2018) Loredana Puca et al.   Nature Communications

PhysiCell: An open source physics-based cell simulator for 3-D multicellular systems

(2018) Ahmadreza Ghaffarizadeh et al.   PLoS Computational Biology

Organoids reveal cancer dynamics

(2018) Calvin J. Kuo et al.   NATURE

Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations

(2017) Julia Jabs et al.   Molecular Systems Biology

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo

(2016) Christopher G. Hubert et al.   CANCER RESEARCH

Organoids: A historical perspective of thinking in three dimensions

(2016) Marina Simian et al.   JOURNAL OF CELL BIOLOGY

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Human mini-guts: new insights into intestinal physiology and host–pathogen interactions

(2016) Julie G. In et al.   Nature Reviews Gastroenterology & Hepatology

Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data

(2016) Nick Jagiella et al.   PLoS Computational Biology

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained

(2016) Michele Zanoni et al.   Scientific Reports

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours

(2015) Tan A. Ince et al.   Nature Communications

Evolution and Phenotypic Selection of Cancer Stem Cells

(2015) Jan Poleszczuk et al.   PLoS Computational Biology

The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: A hybrid model study

(2014) MunJu Kim et al.   JOURNAL OF THEORETICAL BIOLOGY

Multilayer Spheroids To Quantify Drug Uptake and Diffusion in 3D

(2014) Toni-Marie Achilli et al.   MOLECULAR PHARMACEUTICS

Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis

(2014) Ville Härmä et al.   PLoS One

Predictive Models of Diffusive Nanoparticle Transport in 3-Dimensional Tumor Cell Spheroids

(2013) Yue Gao et al.   AAPS Journal

Size-Based Isolation of Circulating Tumor Cells in Lung Cancer Patients Using a Microcavity Array System

(2013) Masahito Hosokawa et al.   PLoS One

Ovarian Tumor Attachment, Invasion, and Vascularization Reflect Unique Microenvironments in the Peritoneum: Insights from Xenograft and Mathematical Models

(2013) Mara P. Steinkamp et al.   Frontiers in Oncology

Characterising the tumour morphological response to therapeutic intervention: an ex vivo model

(2012) A. Savage et al.   Disease Models & Mechanisms

Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery

(2012) Dmitry A. Markov et al.   LAB ON A CHIP

Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models

(2012) Jenny Z. Zhang et al.   Metallomics

Integrating Intracellular Dynamics Using CompuCell3D and Bionetsolver: Applications to Multiscale Modelling of Cancer Cell Growth and Invasion

(2012) Vivi Andasari et al.   PLoS One

Hypoxic Conditions Induce a Cancer-Like Phenotype in Human Breast Epithelial Cells

(2012) Marica Vaapil et al.   PLoS One

Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling

(2011) Jonathan Tang et al.   Integrative Biology

A computational approach to resolve cell level contributions to early glandular epithelial cancer progression

(2010) Sean HJ Kim et al.   BMC Systems Biology

Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma

(2010) K. A. Rejniak et al.   MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA

Front Instabilities and Invasiveness of Simulated 3D Avascular Tumors

(2010) Nikodem J. Poplawski et al.   PLoS One

A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

(2010) Ville Härmä et al.   PLoS One

Emergent Properties of Tumor Microenvironment in a Real-Life Model of Multicell Tumor Spheroids

(2010) Edoardo Milotti et al.   PLoS One

Linking Changes in Epithelial Morphogenesis to Cancer Mutations Using Computational Modeling

(2010) Katarzyna A. Rejniak et al.   PLoS Computational Biology

Increasingly transformed MCF-10A cells have a progressively tumor-like phenotype in three-dimensional basement membrane culture

(2009) Karen M Imbalzano et al.   Cancer Cell International

Microenvironmental Independence Associated with Tumor Progression

(2009) A. R.A. Anderson et al.   CANCER RESEARCH

Solvent accessible surface area approximations for rapid and accurate protein structure prediction

(2009) Elizabeth Durham et al.   JOURNAL OF MOLECULAR MODELING

Temporal Organization of the Cell Cycle

(2008) John J. Tyson et al.   CURRENT BIOLOGY

Collective Epithelial Migration and Cell Rearrangements Drive Mammary Branching Morphogenesis

(2008) Andrew J. Ewald et al.   DEVELOPMENTAL CELL

Molecular signatures associated with transformation and progression to breast cancer in the isogenic MCF10 model

(2008) Dong Keun Rhee et al.   GENOMICS

Radius of gyration as an indicator of protein structure compactness

(2008) M. Yu. Lobanov et al.   MOLECULAR BIOLOGY