Review
Biotechnology & Applied Microbiology
Paula M. Tribelli, Nancy Lopez
Summary: This review provides an overview of temperature-response mechanisms in Pseudomonas species and highlights their relevance to human and animal health as well as agricultural applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qianqiao Liu, Beth M. Stadtmueller
Summary: This study reports cryo-EM structures of complexes formed by Streptococcus pyogenes with host immunoglobulin A (IgA) and host IgA Fc receptors. The results reveal different binding modes of IgA to S. pyogenes M4 and human Fc alpha R1/CD89, providing important insights into understanding host-microbe interactions and improving outcomes of group A Streptococcus infection.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Yibin Yang, Xia Zhu, Haixin Zhang, Yuhua Chen, Yi Song, Xiaohui Ai
Summary: The study on the host-pathogen interaction between channel catfish and Yersinia ruckeri revealed the dynamic regulation of the transcriptome during infection, with significant upregulation of immune-related pathways. Specifically, the infection was found to be closely related to metabolic pathways, and the pathogenesis promoted by Y. ruckeri in channel catfish was mainly through the flagellum gene fliC. This research contributes to understanding how catfish respond to infection and develop enteric red mouth disease (ERM) through a transcriptional perspective.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Ankur Midha, Victor Hugo Jarquin-Diaz, Friederike Ebner, Ulrike Lober, Rima Hayani, Arkadi Kundik, Alessio Cardilli, Emanuel Heitlinger, Sofia Kirke Forslund, Susanne Hartmann
Summary: The study compared the intestinal microbiome of the parasitic nematode Ascaris suum with its host, revealing that the parasite has a less diverse microbiome than the host, and the host shows reduced microbiome diversity at the site of parasite infection. The microbiome composition of the host at the infection site significantly influences the microbiome composition of the parasite.
Article
Microbiology
Sebastien C. Ortiz, Katie Pennington, Darren D. Thomson, Margherita Bertuzzi
Summary: Aspergillus fumigatus spores cause millions of chronic and invasive diseases annually, with a high mortality rate. Increasing resistance to antifungal treatments and limited understanding of the pathogenesis and host response have hindered the development of effective therapeutic strategies. Recent advances in sample preparation, infection models, and imaging techniques have provided valuable insights into host-pathogen interactions and potential treatments.
Article
Chemistry, Multidisciplinary
Shideng Yuan, Heng Zhang, Shiling Yuan
Summary: Supramolecular polymer flooding has the potential to solve injection difficulties and low recovery in low-permeability polymer reservoirs. Molecular dynamics simulations were used to explore the formation of supramolecular polymer hydrogels and evaluate the effect of concentration on the oil displacement index. The self-assembly mechanism was summarized and the importance of Na+ in forming a compact 3D network structure was highlighted.
Article
Immunology
Adam M. Blanchard, Ceri E. Staley, Laurence Shaw, Sean R. Wattegedera, Christina-Marie Baumbach, Jule K. Michler, Catrin Rutland, Charlotte Back, Nerissa Newbold, Gary Entrican, Sabine Totemeyer
Summary: This study presents the first combined global analysis of bacterial community transcripts and host immune response in healthy and diseased ovine feet during a natural polymicrobial infection state using metatranscriptomics. It reveals that footrot-affected skin has reduced diversity and increased abundances of not only the causative bacterium Dichelobacter nodosus, but also other species. Host transcriptomics show suppression of biological processes related to skin barrier function, vascular functions, and immunosurveillance in unhealthy interdigital skin, supported by histological findings.
INFECTION AND IMMUNITY
(2021)
Review
Biochemistry & Molecular Biology
Allan Radaic, Yvonne L. Kapila
Summary: The oralome is a summary of the interactions between oral microorganisms and the host, which can impact the health and disease status of the host. Current research focuses on changes in the oral microbiome in the oral environment and discusses techniques for modulating the dysbiotic oral microbiome to prevent and treat diseases.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Immunology
Silke Machata, Sravya Sreekantapuram, Kerstin Huenniger, Oliver Kurzai, Christine Dunker, Katja Schubert, Wibke Krueger, Bianca Schulze-Richter, Cornelia Speth, Guenter Rambach, Ilse D. Jacobsen
Summary: By adapting the human whole-blood model to murine blood, it was found that murine blood has a weaker ability to reduce fungal burden and control filamentation of C. albicans compared to human blood. The lower neutrophil count in murine blood partially explains the insufficient infection control, and differences in host-pathogen interactions were observed, particularly in platelet interactions with C. albicans.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Joshua Oluoch Amimo, Sergei Alekseevich Raev, Juliet Chepngeno, Alfred Omwando Mainga, Yusheng Guo, Linda Saif, Anastasia N. Vlasova
Summary: Rotavirus is a major pathogen causing severe diarrheal illness in young children and animals worldwide, infecting mature enterocytes in the intestinal epithelium. The immune system of intestinal epithelial cells plays a crucial role in countering rotavirus invasion, while rotavirus has evolved mechanisms to evade host immunity. Understanding the mechanisms of rotavirus-IECs interactions is essential for developing strategies to control infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
David Smith, Daniel R. G. Price, Alison Burrells, Marc N. Faber, Katie A. Hildersley, Cosmin Chintoan-Uta, Ambre F. Chapuis, Mark Stevens, Karen Stevenson, Stewart T. G. Burgess, Elisabeth A. Innes, Alasdair J. Nisbet, Tom N. McNeilly
Summary: The development of ovine epithelial organoids provides a valuable tool for studying interactions between pathogens and epithelial cells in sheep gastrointestinal infections. These organoids exhibit stable transcript profiles and can be cryopreserved, reducing the need for animal experimentation. Furthermore, they can be used for pathogen co-culture experiments, showcasing their potential utility in pathogen research.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah E. Post, Ilana L. Brito
Summary: Protein-protein interactions between the microbiome and host organism play a crucial role in determining host health and have potential therapeutic applications. Structural analysis of these interactions provides valuable insights into the mechanisms and influence on host cell processes. Further research is needed to enhance the detection of proteins with therapeutic potential.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2022)
Article
Entomology
Jonathan J. Giacomini, Nicholas Moore, Lynn S. Adler, Rebecca E. Irwin
Summary: A study has found that the consumption of sunflower pollen can significantly reduce gut infection by a protozoan pathogen in bumble bees and alter the physiological function of the gut, resulting in faster and increased excretion.
JOURNAL OF INSECT PHYSIOLOGY
(2022)
Article
Biology
Arni Kristmundsson, Asthildur Erlingsdottir, Sigrun Lange
Summary: Alveolates are a diverse group of organisms, including apicomplexans and chromerids, with varying pathogenicity and life cycle strategies. Understanding protein deimination in these parasites may provide new insights into their adaptability and host-pathogen interactions.
