期刊
NATURE COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/ncomms8419
关键词
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资金
- Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami
- Breast Cancer Research Foundation, New York, NY
- DoD-CDMRP Ovarian Cancer Research Program Resource Development Grant [W81XWH-14-1-0160, OC130649]
- National Cancer Institute, Roadmap Epigenomics project [R01-CA146445-01]
- Advanced Medical Research Foundation
- Dr Miriam and Sheldon D. Adelson Medical Research Foundation
- CCSG grant [P30 CA016672, R01CA123219]
- CDMRP [672320, OC130649] Funding Source: Federal RePORTER
Currently available human tumour cell line panels consist of a small number of lines in each lineage that generally fail to retain the phenotype of the original patient tumour. Here we develop a cell culture medium that enables us to routinely establish cell lines from diverse subtypes of human ovarian cancers with >95% efficiency. Importantly, the 25 new ovarian tumour cell lines described here retain the genomic landscape, histopathology and molecular features of the original tumours. Furthermore, the molecular profile and drug response of these cell lines correlate with distinct groups of primary tumours with different outcomes. Thus, tumour cell lines derived using this methodology represent a significantly improved platform to study human tumour pathophysiology and response to therapy.
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