Prioritizing target-disease associations with novel safety and efficacy scoring methods
出版年份 2019 全文链接
标题
Prioritizing target-disease associations with novel safety and efficacy scoring methods
作者
关键词
-
出版物
Scientific Reports
Volume 9, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-08
DOI
10.1038/s41598-019-46293-7
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Alzheimer's Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits
- (2018) Shreyasi Chatterjee et al. Frontiers in Neuroscience
- Acute and long-term effects of fingolimod on heart rhythm and heart rate variability in patients with multiple sclerosis
- (2018) Ruken Özge Akbulak et al. Multiple Sclerosis and Related Disorders
- In silico prediction of novel therapeutic targets using gene–disease association data
- (2017) Enrico Ferrero et al. Journal of Translational Medicine
- ADReCS-Target: target profiles for aiding drug safety research and application
- (2017) Li-Hong Huang et al. NUCLEIC ACIDS RESEARCH
- A knowledge-based approach for predicting gene–disease associations
- (2016) Hongyi Zhou et al. BIOINFORMATICS
- Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice
- (2016) Yoshihiko Kitada et al. ENDOCRINOLOGY
- Innovation in the pharmaceutical industry: New estimates of R&D costs
- (2016) Joseph A. DiMasi et al. JOURNAL OF HEALTH ECONOMICS
- Phase II and phase III failures: 2013–2015
- (2016) Richard K. Harrison NATURE REVIEWS DRUG DISCOVERY
- Pharos: Collating protein information to shed light on the druggable genome
- (2016) Dac-Trung Nguyen et al. NUCLEIC ACIDS RESEARCH
- Open Targets: a platform for therapeutic target identification and validation
- (2016) Gautier Koscielny et al. NUCLEIC ACIDS RESEARCH
- Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues
- (2016) Vinod Kumar et al. Scientific Reports
- Tissue Specificity of Human Disease Module
- (2016) Maksim Kitsak et al. Scientific Reports
- Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway
- (2015) Nami Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TWIST1 and TWIST2 regulate glycogen storage and inflammatory genes in skeletal muscle
- (2015) J. M. Mudry et al. JOURNAL OF ENDOCRINOLOGY
- Liver histone H3 methylation and acetylation may associate with type 2 diabetes development
- (2015) Peipei Tu et al. JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
- DISEASES: Text mining and data integration of disease–gene associations
- (2015) Sune Pletscher-Frankild et al. METHODS
- The support of human genetic evidence for approved drug indications
- (2015) Matthew R Nelson et al. NATURE GENETICS
- Therapeutic Potential of GPR120 Agonists for the Treatment of Type 2 Diabetes
- (2015) Ahmed F. Abdel-Magid ACS Medicinal Chemistry Letters
- DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
- (2015) J. Pinero et al. Database-The Journal of Biological Databases and Curation
- Epigenetic Alterations in Alzheimer’s Disease
- (2015) Jose V. Sanchez-Mut et al. Frontiers in Behavioral Neuroscience
- GUILDify: a web server for phenotypic characterization of genes through biological data integration and network-based prioritization algorithms
- (2014) Emre Guney et al. BIOINFORMATICS
- Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
- (2014) David Cook et al. NATURE REVIEWS DRUG DISCOVERY
- Translational paradigms in pharmacology and drug discovery
- (2013) Kevin Mullane et al. BIOCHEMICAL PHARMACOLOGY
- Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
- (2013) Edward Y Chen et al. BMC BIOINFORMATICS
- Genetics of rheumatoid arthritis contributes to biology and drug discovery
- (2013) Yukinori Okada et al. NATURE
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- FTY720/Fingolimod, a Sphingosine Analogue, Reduces Amyloid-β Production in Neurons
- (2013) Nobumasa Takasugi et al. PLoS One
- Use of genome-wide association studies for drug repositioning
- (2012) Philippe Sanseau et al. NATURE BIOTECHNOLOGY
- What makes a good drug target?
- (2011) Isabella Gashaw et al. DRUG DISCOVERY TODAY
- OGEE: an online gene essentiality database
- (2011) Wei-Hua Chen et al. NUCLEIC ACIDS RESEARCH
- Disease Ontology: a backbone for disease semantic integration
- (2011) L. M. Schriml et al. NUCLEIC ACIDS RESEARCH
- Modeling sample variables with an Experimental Factor Ontology
- (2010) James Malone et al. BIOINFORMATICS
- Principles of early drug discovery
- (2010) JP Hughes et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cellular Retinol-Binding Protein Type I (CRBP-I) Regulates Adipogenesis
- (2010) C. F. Zizola et al. MOLECULAR AND CELLULAR BIOLOGY
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