The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
出版年份 2019 全文链接
标题
The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy
作者
关键词
-
出版物
Nature Communications
Volume 10, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-05-22
DOI
10.1038/s41467-019-09929-w
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- The lipodystrophic hotspot lamin A p.R482W mutation deregulates the mesodermal inducer T/Brachyury and early vascular differentiation gene networks
- (2018) Nolwenn Briand et al. HUMAN MOLECULAR GENETICS
- Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation
- (2018) Maria Chatzifrangkeskou et al. HUMAN MOLECULAR GENETICS
- Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene
- (2018) Coline Macquart et al. HUMAN MOLECULAR GENETICS
- Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation
- (2018) Nolwenn Briand et al. Nucleus
- Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation
- (2018) Nolwenn Briand et al. Nucleus
- Single molecule analysis of lamin dynamics
- (2018) Leonid A. Serebryannyy et al. METHODS
- Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA Mutations
- (2018) Heather B. Steele-Stallard et al. Frontiers in Physiology
- A lipodystrophy-causing lamin A mutant alters conformation and epigenetic regulation of the anti-adipogenic MIR335 locus
- (2017) Anja Oldenburg et al. JOURNAL OF CELL BIOLOGY
- Modeling Treatment Response for Lamin A/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells
- (2017) Yee‐Ki Lee et al. Journal of the American Heart Association
- Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation
- (2016) Yogananda S. Markandeya et al. HEART RHYTHM
- Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers
- (2016) Saurabh Kumar et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
- (2016) Ian Y. Chen et al. Nature Reviews Cardiology
- Laminopathies disrupt epigenomic developmental programs and cell fate
- (2016) Jelena Perovanovic et al. Science Translational Medicine
- Adeno-associated virus-mediated CASQ2 delivery rescues phenotypic alterations in a patient-specific model of recessive catecholaminergic polymorphic ventricular tachycardia
- (2016) Francesco Lodola et al. Cell Death & Disease
- Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay
- (2016) F. Marullo et al. Nucleus
- Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay
- (2016) F. Marullo et al. Nucleus
- Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C
- (2016) Jenny CY Ho et al. Aging-US
- Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
- (2016) Chung-Wah Siu et al. Aging-US
- A novel lamin A/C gene missense mutation (445 V > E) in immunoglobulin-like fold associated with left ventricular non-compaction
- (2015) Zhouying Liu et al. EUROPACE
- Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes
- (2015) Elisa Cesarini et al. JOURNAL OF CELL BIOLOGY
- Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins
- (2015) Jennifer C. Harr et al. JOURNAL OF CELL BIOLOGY
- A pre-screening FISH-based method to detect CRISPR/Cas9 off-targets in mouse embryonic stem cells
- (2015) Marianna Paulis et al. Scientific Reports
- Mechanisms of cardiac conduction: a history of revisions
- (2014) Rengasayee Veeraraghavan et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Genome regulation at the peripheral zone: lamina associated domains in development and disease
- (2014) Teresa R Luperchio et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression
- (2013) Philippe Collas et al. BIOESSAYS
- When Lamins Go Bad: Nuclear Structure and Disease
- (2013) Katherine H. Schreiber et al. CELL
- ‘State-of-the-heart’ of cardiac laminopathies
- (2013) Marie-Elodie Cattin et al. CURRENT OPINION IN CARDIOLOGY
- Doubly heterozygous LMNA and TTN mutations revealed by exome sequencing in a severe form of dilated cardiomyopathy
- (2013) Roberta Roncarati et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes
- (2013) E. Lund et al. GENOME RESEARCH
- Electronic “expression” of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells
- (2013) Glenna C.L. Bett et al. HEART RHYTHM
- Temporal Relationship of Conduction System Disease and Ventricular Dysfunction in LMNA Cardiomyopathy
- (2013) Chad Brodt et al. JOURNAL OF CARDIAC FAILURE
- Seamless genome editing in human pluripotent stem cells using custom endonuclease–based gene targeting and the piggyBac transposon
- (2013) Kosuke Yusa Nature Protocols
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- Dilated cardiomyopathy: the complexity of a diverse genetic architecture
- (2013) Ray E. Hershberger et al. Nature Reviews Cardiology
- Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
- (2013) Claire Robertson et al. STEM CELLS
- CaMKII inhibition rectifies arrhythmic phenotype in a patient-specific model of catecholaminergic polymorphic ventricular tachycardia
- (2013) E Di Pasquale et al. Cell Death & Disease
- Mouse models of laminopathies
- (2012) Haoyue Zhang et al. AGING CELL
- Cardiomyocytes Derived From Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
- (2012) Richard P. Davis et al. CIRCULATION
- High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents
- (2011) Junyi Ma et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- LMNA cardiomyopathy: cell biology and genetics meet clinical medicine
- (2011) J. T. Lu et al. Disease Models & Mechanisms
- Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
- (2011) Kosuke Yusa et al. NATURE
- The nuclear envelope as a chromatin organizer
- (2011) Nikolaj Zuleger et al. Nucleus
- Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
- (2010) Alessandra Moretti et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pathology tissue-chromatin immunoprecipitation, coupled with high-throughput sequencing, allows the epigenetic profiling of patient samples
- (2010) M. Fanelli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transcription and the nuclear periphery: edge of darkness?
- (2009) Emmanuelle Deniaud et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Role of A-type lamins in signaling, transcription, and chromatin organization
- (2009) Vicente Andrés et al. JOURNAL OF CELL BIOLOGY
- Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
- (2008) T. Dechat et al. GENES & DEVELOPMENT
- Long-Term Outcome and Risk Stratification in Dilated Cardiolaminopathies
- (2008) Michele Pasotti et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
- (2008) Lars Guelen et al. NATURE
- Transcriptional repression mediated by repositioning of genes to the nuclear lamina
- (2008) K. L. Reddy et al. NATURE
- Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette
- (2008) Cesar A. Sommer et al. STEM CELLS
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