期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 306, 期 5, 页码 H619-H627出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00760.2013
关键词
cardiac conduction; ephaptic coupling; gap junctions; modeling; myocardium
资金
- National Institutes of Health Grants [R01-HL-102298-01A1, R01-HL-56728-10A2, R01-1DE019355-01]
- American Heart Association Postdoctoral Fellowship
Cardiac conduction is the process by which electrical excitation spreads through the heart, triggering individual myocytes to contract in synchrony. Defects in conduction disrupt synchronous activation and are associated with life-threatening arrhythmias in many pathologies. Therefore, it is scarcely surprising that this phenomenon continues to be the subject of active scientific inquiry. Here we provide a brief review of how the conceptual understanding of conduction has evolved over the last century and highlight recent, potentially paradigm-shifting developments.
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