Laminopathy-causing lamin A mutations reconfigure lamina-associated domains and local spatial chromatin conformation

Constrained release of lamina-associated enhancers and genes from the nuclear envelope during T-cell activation facilitates their association in chromosome compartments

(2017) Michael I. Robson et al.   GENOME RESEARCH

Dynamic Rewiring of Promoter-Anchored Chromatin Loops during Adipocyte Differentiation

(2017) Rasmus Siersbæk et al.   MOLECULAR CELL

Complex multi-enhancer contacts captured by genome architecture mapping

(2017) Robert A. Beagrie et al.   NATURE

Lineage-specific dynamic and pre-established enhancer–promoter contacts cooperate in terminal differentiation

(2017) Adam J Rubin et al.   NATURE GENETICS

A Novel Lamin A Mutant Responsible for Congenital Muscular Dystrophy Causes Distinct Abnormalities of the Cell Nucleus

(2017) Alice Barateau et al.   PLoS One

A-type lamins bind both hetero- and euchromatin, the latter being regulated by lamina-associated polypeptide 2 alpha

(2016) Kevin Gesson et al.   GENOME RESEARCH

Activin/Smad2-induced Histone H3 Lys-27 Trimethylation (H3K27me3) Reduction Is Crucial to Initiate Mesendoderm Differentiation of Human Embryonic Stem Cells

(2016) Lu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder

(2016) Yuexia Wang et al.   JOURNAL OF CELL SCIENCE

Extracellular matrix remodeling and transforming growth factor-β signaling abnormalities induced by lamin A/C variants that cause lipodystrophy

(2016) Caroline Le Dour et al.   JOURNAL OF LIPID RESEARCH

Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis

(2016) Michael I. Robson et al.   MOLECULAR CELL

Population-based 3D genome structure analysis reveals driving forces in spatial genome organization

(2016) Harianto Tjong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Laminopathies disrupt epigenomic developmental programs and cell fate

(2016) Jelena Perovanovic et al.   Science Translational Medicine

Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay

(2016) F. Marullo et al.   Nucleus

The nuclear lamina in health and disease

(2016) Agnieszka Dobrzynska et al.   Nucleus

Nucleoplasmic Lamin A/C and Polycomb group of proteins: An evolutionarily conserved interplay

(2016) F. Marullo et al.   Nucleus

The nuclear lamina in health and disease

(2016) Agnieszka Dobrzynska et al.   Nucleus

Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells

(2015) Jop Kind et al.   CELL

Lamins at the crossroads of mechanosignaling

(2015) Selma Osmanagic-Myers et al.   GENES & DEVELOPMENT

Prepatterning of differentiation-driven nuclear lamin A/C-associated chromatin domains by GlcNAcylated histone H2B

(2015) Torunn Rønningen et al.   GENOME RESEARCH

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes

(2015) Elisa Cesarini et al.   JOURNAL OF CELL BIOLOGY

PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription

(2015) Honglei Zhao et al.   MOLECULAR CELL

Loss of lamin A function increases chromatin dynamics in the nuclear interior

(2015) I. Bronshtein et al.   Nature Communications

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

Distinct features of lamin A-interacting chromatin domains mapped by ChIP-sequencing from sonicated or micrococcal nuclease-digested chromatin

(2015) Eivind G Lund et al.   Nucleus

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Three-dimensional modeling of the P. falciparum genome during the erythrocytic cycle reveals a strong connection between genome architecture and gene expression

(2014) F. Ay et al.   GENOME RESEARCH

The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy

(2014) Nathalie Vadrot et al.   HUMAN MOLECULAR GENETICS

3D genome reconstruction from chromosomal contacts

(2014) Annick Lesne et al.   NATURE METHODS

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations

(2014) Eivind Lund et al.   NUCLEIC ACIDS RESEARCH

Nuclear envelope-related lipodystrophies

(2014) A.C. Guénantin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Multiple novel functions of Lamina associated polypeptide 2α in striated muscle

(2014) Ivana Gotic et al.   Nucleus

Stochastic genome-nuclear lamina interactions

(2014) Jop Kind et al.   Nucleus

Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction

(2013) Guillaume Bidault et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Closing the (nuclear) envelope on the genome: How nuclear lamins interact with promoters and modulate gene expression

(2013) Philippe Collas et al.   BIOESSAYS

Single-Cell Dynamics of Genome-Nuclear Lamina Interactions

(2013) Jop Kind et al.   CELL

LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation

(2013) Irina Solovei et al.   CELL

Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence

(2013) M. Sadaie et al.   GENES & DEVELOPMENT

Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape

(2013) P. P. Shah et al.   GENES & DEVELOPMENT

Lamin A/C-promoter interactions specify chromatin state-dependent transcription outcomes

(2013) E. Lund et al.   GENOME RESEARCH

Deregulation of Fragile X-related protein 1 by the lipodystrophic lamin A p.R482W mutation elicits a myogenic gene expression program in preadipocytes

(2013) Anja R. Oldenburg et al.   HUMAN MOLECULAR GENETICS

Defective skeletal muscle growth in lamin A/C-deficient mice is rescued by loss of Lap2α

(2013) Tatiana V. Cohen et al.   HUMAN MOLECULAR GENETICS

Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

(2013) Job Dekker et al.   NATURE REVIEWS GENETICS

EZH2andKDM6AAct as an Epigenetic Switch to Regulate Mesenchymal Stem Cell Lineage Specification

(2013) Sarah Hemming et al.   STEM CELLS

Bayesian Inference of Spatial Organizations of Chromosomes

(2013) Ming Hu et al.   PLoS Computational Biology

Nuclear lamins

(2013) Eivind Lund et al.   Nucleus

Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence

(2012) W. Meuleman et al.   GENOME RESEARCH

Genome structure determination via 3C-based data integration by the Integrative Modeling Platform

(2012) Davide Baù et al.   METHODS

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Spatial partitioning of the regulatory landscape of the X-inactivation centre

(2012) Elphège P. Nora et al.   NATURE

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recovering ensembles of chromatin conformations from contact probabilities

(2012) Dario Meluzzi et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanisms of human lipodystrophies: From adipocyte lipid droplet to oxidative stress and lipotoxicity

(2011) Corinne Vigouroux et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Lysine-specific Demethylase 2B (KDM2B)-let-7-Enhancer of Zester Homolog 2 (EZH2) Pathway Regulates Cell Cycle Progression and Senescence in Primary Cells

(2011) Alexandros Tzatsos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Genome architectures revealed by tethered chromosome conformation capture and population-based modeling

(2011) Reza Kalhor et al.   NATURE BIOTECHNOLOGY

Regulation of metabolism: the circadian clock dictates the time

(2011) Saurabh Sahar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Lamin A and lamin C form homodimers and coexist in higher complex forms both in the nucleoplasmic fraction and in the lamina of cultured human cells

(2011) Thorsten Kolb et al.   Nucleus

Lamin complexes in the nuclear interior control progenitor cell proliferation and tissue homeostasis

(2010) Nana Naetar et al.   CELL CYCLE

Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation

(2010) Daan Peric-Hupkes et al.   MOLECULAR CELL

Histone H3K27 methyltransferase Ezh2 represses Wnt genes to facilitate adipogenesis

(2010) L. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The R439C mutation inLMNAcauses lamin oligomerization and susceptibility to oxidative stress

(2009) Valerie L.R.M. Verstraeten et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Loss of LAP2α Delays Satellite Cell Differentiation and Affects Postnatal Fiber-Type Determination

(2009) Ivana Gotic et al.   STEM CELLS

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

(2008) Lars Guelen et al.   NATURE

Loss of nucleoplasmic LAP2α–lamin A complexes causes erythroid and epidermal progenitor hyperproliferation

(2008) Nana Naetar et al.   NATURE CELL BIOLOGY