A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease

(2018) Florence A Aeschlimann et al.   ANNALS OF THE RHEUMATIC DISEASES

Haploinsufficiency of A20 causes autoinflammatory and autoimmune disorders

(2018) Tomonori Kadowaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts

(2018) Marietta Armaka et al.   Nature Communications

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

(2018) Sofie Voet et al.   Nature Communications

A20/Tumor Necrosis Factor α-Induced Protein 3 in Immune Cells Controls Development of Autoinflammation and Autoimmunity: Lessons from Mouse Models

(2018) Tridib Das et al.   Frontiers in Immunology

Haploinsufficiency of TNFAIP3 ( A20 ) by germline mutation is involved in autoimmune lymphoproliferative syndrome

(2017) Masatoshi Takagi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner

(2017) Stephanie A. Conos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Rheumatoid arthritis

(2016) Josef S Smolen et al.   LANCET

RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation

(2016) Juan Lin et al.   NATURE

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death

(2016) L Catrysse et al.   Cell Death & Disease

The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis

(2015) Noritaka Yamaguchi et al.   FEBS LETTERS

TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice

(2015) Katerina Vlantis et al.   GUT

A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

(2015) Bao H. Duong et al.   IMMUNITY

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

(2015) Qing Zhou et al.   NATURE GENETICS

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

(2015) Michio Onizawa et al.   NATURE IMMUNOLOGY

LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

(2015) Peter Draber et al.   Cell Reports

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The deubiquitinase activity of A20 is dispensable for NF- B signaling

(2014) A. De et al.   EMBO REPORTS

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

Real-time single-cell imaging of protein secretion

(2014) Yoshitaka Shirasaki et al.   Scientific Reports

Single-Cell Imaging of Caspase-1 Dynamics Reveals an All-or-None Inflammasome Signaling Response

(2014) Ting Liu et al.   Cell Reports

A20-Deficient Mast Cells Exacerbate Inflammatory Responses In Vivo

(2014) Klaus Heger et al.   PLOS BIOLOGY

Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme

(2013) Timothy T. Lu et al.   IMMUNITY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

A20 in inflammation and autoimmunity

(2013) Leen Catrysse et al.   TRENDS IN IMMUNOLOGY

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

(2012) Kelly Verhelst et al.   EMBO JOURNAL

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

(2012) Fuminori Tokunaga et al.   EMBO JOURNAL

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

(2012) Chhinder P. Sodhi et al.   GASTROENTEROLOGY

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

Cutting Edge: Divergent Cell-Specific Functions of MyD88 for Inflammatory Responses and Organ Injury in Septic Peritonitis

(2012) P. Gais et al.   JOURNAL OF IMMUNOLOGY

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

(2012) S. K. Drexler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic relationships betweenA20/TNFAIP3, chronic inflammation and autoimmune disease

(2011) Lars Vereecke et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

(2011) S Lippens et al.   CELL DEATH AND DIFFERENTIATION

The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

(2011) Mirjam Kool et al.   IMMUNITY

Direct, Noncatalytic Mechanism of IKK Inhibition by A20

(2011) Brian Skaug et al.   MOLECULAR CELL

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

(2011) Mourad Matmati et al.   NATURE GENETICS

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

(2011) Gianna Elena Hammer et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

(2010) Y. Chu et al.   BLOOD

The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

(2010) Rita M. Tavares et al.   IMMUNITY

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

(2010) Lars Vereecke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

(2010) Ivan Bosanac et al.   MOLECULAR CELL

The NF- B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas

(2009) U. Novak et al.   BLOOD

TNFAIP3(A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma

(2009) Roland Schmitz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mutations of multiple genes cause deregulation of NF-κB in diffuse large B-cell lymphoma

(2009) Mara Compagno et al.   NATURE

Frequent inactivation of A20 in B-cell lymphomas

(2009) Motohiro Kato et al.   NATURE

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

(2008) Maria Armaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE