标题
Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
作者
关键词
Lysosome, aging, neurodegeneration, autophagy, therapeutic targets
出版物
Neurotherapeutics
Volume -, Issue -, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-06-11
DOI
10.1007/s13311-019-00742-3
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Regulation and Function of Mitochondria–Lysosome Membrane Contact Sites in Cellular Homeostasis
- (2019) Yvette C. Wong et al. TRENDS IN CELL BIOLOGY
- Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension
- (2019) Ben Zhou et al. CELL
- Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment
- (2018) Candice E. Van Skike et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype
- (2018) Georgia Minakaki et al. Autophagy
- Coordination of Autophagosome–Lysosome Fusion by Atg8 Family Members
- (2018) Franziska Kriegenburg et al. CURRENT BIOLOGY
- Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance
- (2018) Sarah Pickles et al. CURRENT BIOLOGY
- Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
- (2018) Chao Wang et al. CURRENT OPINION IN NEUROBIOLOGY
- Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis
- (2018) Andrew E. Arrant et al. JOURNAL OF NEUROSCIENCE
- Mitochondria–lysosome contacts regulate mitochondrial fission via RAB7 GTP hydrolysis
- (2018) Yvette C. Wong et al. NATURE
- Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases
- (2018) Charleen T. Chu NEUROBIOLOGY OF DISEASE
- Resveratrol activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against amyloid-beta-induced inflammation and oxidative stress
- (2018) Ming-Chang Chiang et al. NEUROCHEMISTRY INTERNATIONAL
- Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide
- (2018) Friederike Zunke et al. NEURON
- Autophagic Modulation by Trehalose Reduces Accumulation of TDP-43 in a Cell Model of Amyotrophic Lateral Sclerosis via TFEB Activation
- (2018) Ying Wang et al. NEUROTOXICITY RESEARCH
- Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging
- (2018) Dena S. Leeman et al. SCIENCE
- LRRK2 kinase in Parkinson's disease
- (2018) Dario R. Alessi et al. SCIENCE
- Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy
- (2018) Natascha Fussi et al. Cell Death & Disease
- The Aging of Iron Man
- (2018) Azhaar Ashraf et al. Frontiers in Aging Neuroscience
- Inhibition of mTORC1 Signaling Reverts Cognitive and Affective Deficits in a Mouse Model of Parkinson’s Disease
- (2018) Débora Masini et al. Frontiers in Neurology
- Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
- (2018) Philip Seibler et al. BRAIN
- Decreased Expression of Cathepsin D in Monocytes is Related to the Defective Degradation of Amyloid-β in Alzheimer's Disease
- (2018) Li Tian et al. JOURNAL OF ALZHEIMERS DISEASE
- A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold
- (2018) Rosalie E. Lawrence et al. NATURE CELL BIOLOGY
- Therapeutic strategies for Parkinson disease: beyond dopaminergic drugs
- (2018) Delphine Charvin et al. NATURE REVIEWS DRUG DISCOVERY
- A role for autophagy in Huntington's disease
- (2018) Katherine R. Croce et al. NEUROBIOLOGY OF DISEASE
- LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
- (2018) Tomoya Eguchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Frontotemporal dementia causative CHMP2B impairs neuronal endolysosomal traffic-rescue by TMEM106B knockdown
- (2018) Emma L Clayton et al. BRAIN
- Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
- (2018) E. Ray Dorsey et al. LANCET NEUROLOGY
- Autophagy and the cell biology of age-related disease
- (2018) Andrew M. Leidal et al. NATURE CELL BIOLOGY
- A pH-correctable, DNA-based fluorescent reporter for organellar calcium
- (2018) Nagarjun Narayanaswamy et al. NATURE METHODS
- Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson’s disease/dementia with Lewy bodies
- (2018) Getaw Worku Hassen et al. Scientific Reports
- Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease
- (2018) Christy O.Y. Hung et al. Cell Reports
- ALS-Associated E478G Mutation in Human OPTN (Optineurin) Promotes Inflammation and Induces Neuronal Cell Death
- (2018) Zhengzhao Liu et al. Frontiers in Immunology
- Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome
- (2018) Antonella Tramutola et al. Translational Neurodegeneration
- Amyloid precursor protein and endosomal–lysosomal dysfunction in Alzheimer’s disease: inseparable partners in a multifactorial disease
- (2017) Ralph A. Nixon FASEB JOURNAL
- Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients
- (2017) Clarissa Valdez et al. HUMAN MOLECULAR GENETICS
- Mitochondrial fission facilitates the selective mitophagy of protein aggregates
- (2017) Jonathon L. Burman et al. JOURNAL OF CELL BIOLOGY
- Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease
- (2017) Charbel Moussa et al. Journal of Neuroinflammation
- Mutant Huntingtin Is Secreted via a Late Endosomal/Lysosomal Unconventional Secretory Pathway
- (2017) Katarina Trajkovic et al. JOURNAL OF NEUROSCIENCE
- Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
- (2017) Dilan Athauda et al. LANCET
- Therapies targeting DNA and RNA in Huntington's disease
- (2017) Edward J Wild et al. LANCET NEUROLOGY
- Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson’s Disease
- (2017) Rosalba Siracusa et al. MOLECULAR NEUROBIOLOGY
- The lysosomal protein cathepsin L is a progranulin protease
- (2017) Chris W. Lee et al. Molecular Neurodegeneration
- Lysosomal processing of progranulin
- (2017) Xiaolai Zhou et al. Molecular Neurodegeneration
- CRISPR/Cas9 Editing of the Mutant Huntingtin Allele In Vitro and In Vivo
- (2017) Alex Mas Monteys et al. MOLECULAR THERAPY
- A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
- (2017) Diana Chang et al. NATURE GENETICS
- Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models
- (2017) S. Pablo Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes
- (2017) Monther Abu-Remaileh et al. SCIENCE
- Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
- (2017) Lena F. Burbulla et al. SCIENCE
- Oral ambroxol increases brain glucocerebrosidase activity in a nonhuman primate
- (2017) Anna Migdalska-Richards et al. SYNAPSE
- Autophagy Receptors and Neurodegenerative Diseases
- (2017) Zhiqiang Deng et al. TRENDS IN CELL BIOLOGY
- Repair, Reuse, Recycle: The Expanding Role of Autophagy in Genome Maintenance
- (2017) Graeme Hewitt et al. TRENDS IN CELL BIOLOGY
- Corrigendum: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases
- (2017) Michela Palmieri et al. Nature Communications
- Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
- (2017) Martin Steger et al. eLife
- Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease
- (2017) Lijuan Zhang et al. MEDICAL SCIENCE MONITOR
- Mitophagy Failure in Fibroblasts and iPSC-Derived Neurons of Alzheimer’s Disease-Associated Presenilin 1 Mutation
- (2017) Patricia Martín-Maestro et al. Frontiers in Molecular Neuroscience
- The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo
- (2017) Tal Nuriel et al. Frontiers in Neuroscience
- The small molecule AUTEN-99 (autophagy enhancer-99) prevents the progression of neurodegenerative symptoms
- (2017) Tibor Kovács et al. Scientific Reports
- Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology
- (2016) Inger Lauritzen et al. ACTA NEUROPATHOLOGICA
- The crucial impact of lysosomes in aging and longevity
- (2016) Didac Carmona-Gutierrez et al. AGEING RESEARCH REVIEWS
- Disorders of lysosomal acidification—The emerging role of v-ATPase in aging and neurodegenerative disease
- (2016) Daniel J. Colacurcio et al. AGEING RESEARCH REVIEWS
- Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice
- (2016) Anna Migdalska-Richards et al. ANNALS OF NEUROLOGY
- Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases
- (2016) Mathieu Bourdenx et al. Autophagy
- Impairment of chaperone-mediated autophagy induces dopaminergic neurodegeneration in rats
- (2016) Maria Xilouri et al. Autophagy
- A lysosome-centered view of nutrient homeostasis
- (2016) Vinod K. Mony et al. Autophagy
- Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
- (2016) Matteo Bordi et al. Autophagy
- Activation of apoptosis signalling pathways by reactive oxygen species
- (2016) Maureen Redza-Dutordoir et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ
- (2016) J. Scott Miners et al. BRAIN PATHOLOGY
- Genetics of Frontotemporal Dementia
- (2016) Diana A. Olszewska et al. Current Neurology and Neuroscience Reports
- The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
- (2016) Christopher P Webster et al. EMBO JOURNAL
- Loss of Mitochondrial Function Impairs Lysosomes
- (2016) Julie Demers-Lamarche et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clusterin Binds to Aβ1–42Oligomers with High Affinity and Interferes with Peptide Aggregation by Inhibiting Primary and Secondary Nucleation
- (2016) Marten Beeg et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The lysosome as a command-and-control center for cellular metabolism
- (2016) Chun-Yan Lim et al. JOURNAL OF CELL BIOLOGY
- TFEB at a glance
- (2016) Gennaro Napolitano et al. JOURNAL OF CELL SCIENCE
- Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+release and Ca2+influx
- (2016) Bethan S. Kilpatrick et al. JOURNAL OF CELL SCIENCE
- Rapamycin rescues vascular, metabolic and learning deficits in apolipoprotein E4 transgenic mice with pre-symptomatic Alzheimer’s disease
- (2016) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
- (2016) Dena G. Hernandez et al. JOURNAL OF NEUROCHEMISTRY
- Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway
- (2016) Pingping Song et al. JOURNAL OF NEUROSCIENCE
- A New Glucocerebrosidase Chaperone Reduces -Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism
- (2016) E. Aflaki et al. JOURNAL OF NEUROSCIENCE
- Activation of -Glucocerebrosidase Reduces Pathological -Synuclein and Restores Lysosomal Function in Parkinson's Patient Midbrain Neurons
- (2016) J. R. Mazzulli et al. JOURNAL OF NEUROSCIENCE
- Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy
- (2016) Erica Barini et al. Molecular Neurodegeneration
- Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects
- (2016) Elena Gammella et al. Oxidative Medicine and Cellular Longevity
- IBMPFD Disease-Causing Mutant VCP/p97 Proteins Are Targets of Autophagic-Lysosomal Degradation
- (2016) Oznur Bayraktar et al. PLoS One
- Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
- (2016) Benjamin Richter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models
- (2016) Joseph R. Mazzulli et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinsons disease
- (2016) A. Ghosh et al. Science Translational Medicine
- Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes
- (2016) Anna Raffaello et al. TRENDS IN BIOCHEMICAL SCIENCES
- MCOLN1 is a ROS sensor in lysosomes that regulates autophagy
- (2016) Xiaoli Zhang et al. Nature Communications
- Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
- (2016) Janet Ugolino et al. PLoS Genetics
- Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy
- (2016) Mengqi Lv et al. Protein & Cell
- The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes
- (2016) Abigail G Garrity et al. eLife
- ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
- (2016) Hugo J.R. Fernandes et al. Stem Cell Reports
- A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
- (2016) M. Yang et al. Science Advances
- Iron promotes protein insolubility and aging in C. elegans
- (2016) Ida M. Klang et al. Aging-US
- Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
- (2016) Alvaro Sanchez-Martinez et al. Scientific Reports
- Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
- (2015) Emma L. Clayton et al. ACTA NEUROPATHOLOGICA
- Autophagy-Related Protein 7 Deficiency in Amyloid β (Aβ) Precursor Protein Transgenic Mice Decreases Aβ in the Multivesicular Bodies and Induces Aβ Accumulation in the Golgi
- (2015) Per Nilsson et al. AMERICAN JOURNAL OF PATHOLOGY
- Lysosomal Storage Diseases: From Pathophysiology to Therapy
- (2015) Giancarlo Parenti et al. Annual Review of Medicine
- Lysosomal Physiology
- (2015) Haoxing Xu et al. Annual Review of Physiology
- Secretory autophagy
- (2015) Marisa Ponpuak et al. CURRENT OPINION IN CELL BIOLOGY
- TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion
- (2015) Q. Xia et al. EMBO JOURNAL
- mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival
- (2015) M. J. Munson et al. EMBO JOURNAL
- Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease
- (2015) Christine Erie et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation
- (2015) Gen Matsumoto et al. HUMAN MOLECULAR GENETICS
- Amino Acid Availability Modulates Vacuolar H+-ATPase Assembly
- (2015) Laura A. Stransky et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Quality Control via the PGC1 -TFEB Signaling Pathway Is Compromised by Parkin Q311X Mutation But Independently Restored by Rapamycin
- (2015) A. Siddiqui et al. JOURNAL OF NEUROSCIENCE
- VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for -Synuclein Degradation and Prevention of Pathogenesis of Parkinson's Disease
- (2015) F.-L. Tang et al. JOURNAL OF NEUROSCIENCE
- Neuronal-Targeted TFEB Accelerates Lysosomal Degradation of APP, Reducing A Generation and Amyloid Plaque Pathogenesis
- (2015) Q. Xiao et al. JOURNAL OF NEUROSCIENCE
- Amino Acid-Dependent mTORC1 Regulation by the Lysosomal Membrane Protein SLC38A9
- (2015) Jennifer Jung et al. MOLECULAR AND CELLULAR BIOLOGY
- Systematic Genetic Analysis of the SMPD1 Gene in Chinese Patients with Parkinson’s Disease
- (2015) Sheng Deng et al. MOLECULAR NEUROBIOLOGY
- Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer’s disease
- (2015) S Kim et al. MOLECULAR PSYCHIATRY
- The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
- (2015) Michael Lazarou et al. NATURE
- SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
- (2015) Manuele Rebsamen et al. NATURE
- Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB
- (2015) Diego L. Medina et al. NATURE CELL BIOLOGY
- Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons
- (2015) Emily M. Rocha et al. NEUROBIOLOGY OF DISEASE
- A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease
- (2015) R. Scott Turner et al. NEUROLOGY
- Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease
- (2015) Dan Xia et al. NEURON
- The contribution of Niemann-Pick SMPD1 mutations to Parkinson disease in Ashkenazi Jews
- (2015) E. Dagan et al. PARKINSONISM & RELATED DISORDERS
- Autophagy in Huntington disease and huntingtin in autophagy
- (2015) Dale D.O. Martin et al. TRENDS IN NEUROSCIENCES
- Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification
- (2015) Ju-Hyun Lee et al. Cell Reports
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine
- (2014) David J. Irwin et al. ACTA NEUROPATHOLOGICA
- MTOR-independent, autophagic enhancer trehalose prolongs motor neuron survival and ameliorates the autophagic flux defect in a mouse model of amyotrophic lateral sclerosis
- (2014) Xiaojie Zhang et al. Autophagy
- Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment
- (2014) Anne-Maria Poehler et al. Autophagy
- Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
- (2014) F M Menzies et al. CELL DEATH AND DIFFERENTIATION
- Receptor-mediated mitophagy in yeast and mammalian systems
- (2014) Lei Liu et al. CELL RESEARCH
- A Dynamic Interface between Vacuoles and Mitochondria in Yeast
- (2014) Yael Elbaz-Alon et al. DEVELOPMENTAL CELL
- Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria
- (2014) Carina Hönscher et al. DEVELOPMENTAL CELL
- A new pathway for mitochondrial quality control: mitochondrial-derived vesicles
- (2014) A. Sugiura et al. EMBO JOURNAL
- C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
- (2014) Manal A. Farg et al. HUMAN MOLECULAR GENETICS
- Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes
- (2014) Stephanie M.Y. Kong et al. HUMAN MOLECULAR GENETICS
- The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
- (2014) Y. C. Wong et al. JOURNAL OF NEUROSCIENCE
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy
- (2014) Vladimir Rogov et al. MOLECULAR CELL
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons
- (2014) Hyun-Hee Ryu et al. NEUROBIOLOGY OF AGING
- Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP
- (2014) E.E. Coffey et al. NEUROSCIENCE
- A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy
- (2014) Franziska Richter et al. Neurotherapeutics
- Neuroprotective effect of the chemical chaperone, trehalose in a chronic MPTP-induced Parkinson's disease mouse model
- (2014) Sumit Sarkar et al. NEUROTOXICOLOGY
- Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
- (2014) Yuan Zhou et al. PLoS One
- Absence of lipofuscin in motor neurons of SOD1-linked ALS mice
- (2014) U. Bandyopadhyay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- LIMP-2 expression is critical for -glucocerebrosidase activity and -synuclein clearance
- (2014) M. Rothaug et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A
- (2014) K. P. Bhat et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis
- (2014) David C. Schöndorf et al. Nature Communications
- Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
- (2014) Eszter Zavodszky et al. Nature Communications
- Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival
- (2014) Fan Zhang et al. Nature Communications
- The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease
- (2014) Senthilkumar S. Karuppagounder et al. Scientific Reports
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- Lifespan Extension by Methionine Restriction Requires Autophagy-Dependent Vacuolar Acidification
- (2014) Christoph Ruckenstuhl et al. PLoS Genetics
- Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology
- (2013) Elisa Teyssou et al. ACTA NEUROPATHOLOGICA
- Tyrosine kinase inhibition facilitates autophagic SNCA/α-synuclein clearance
- (2013) Michaeline L. Hebron et al. Autophagy
- Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons
- (2013) Karen Castillo et al. Autophagy
- Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation
- (2013) Claudia Manzoni et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration
- (2013) Maria Xilouri et al. BRAIN
- Autophagy Enhancer Carbamazepine Alleviates Memory Deficits and Cerebral Amyloid-β Pathology in a Mouse Model of Alzheimer's Disease
- (2013) Lixi Li et al. Current Alzheimer Research
- Loss of iron triggers PINK1/Parkin-independent mitophagy
- (2013) George F G Allen et al. EMBO REPORTS
- Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy
- (2013) Hitoshi Nakatogawa Essays in Biochemistry
- Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification
- (2013) Devin M. Wolfe et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits
- (2013) Patrick J. Schultheis et al. HUMAN MOLECULAR GENETICS
- Zn2+ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation
- (2013) Taiji Tsunemi et al. HUMAN MOLECULAR GENETICS
- Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease models
- (2013) M. L. Hebron et al. HUMAN MOLECULAR GENETICS
- Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
- (2013) Patrick Ejlerskov et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
- (2013) Selcuk A. Tanik et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chronic Rapamycin Restores Brain Vascular Integrity and Function Through NO Synthase Activation and Improves Memory in Symptomatic Mice Modeling Alzheimer’s Disease
- (2013) Ai-Ling Lin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- An Extended Proteome Map of the Lysosomal Membrane Reveals Novel Potential Transporters
- (2013) Agnès Chapel et al. MOLECULAR & CELLULAR PROTEOMICS
- The role ofSCARB2as susceptibility factor in Parkinson's disease
- (2013) Franziska Hopfner et al. MOVEMENT DISORDERS
- Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
- (2013) Charleen T. Chu et al. NATURE CELL BIOLOGY
- ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
- (2013) Ryan C. Russell et al. NATURE CELL BIOLOGY
- Genetic variation in Clusterin gene and Alzheimer's disease risk in Han Chinese
- (2013) Jin-Tai Yu et al. NEUROBIOLOGY OF AGING
- The p.L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease
- (2013) Z. Gan-Or et al. NEUROLOGY
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- The V471A Polymorphism in Autophagy-Related Gene ATG7 Modifies Age at Onset Specifically in Italian Huntington Disease Patients
- (2013) Silke Metzger et al. PLoS One
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Vps35 D620N Mutation Linked to Parkinson's Disease Disrupts the Cargo Sorting Function of Retromer
- (2013) Jordan Follett et al. TRAFFIC
- Aβ Secretion and Plaque Formation Depend on Autophagy
- (2013) Per Nilsson et al. Cell Reports
- Epidemiology of Alzheimer Disease
- (2013) R. Mayeux et al. Cold Spring Harbor Perspectives in Medicine
- Strikingly Different Clinicopathological Phenotypes Determined by Progranulin-Mutation Dosage
- (2012) Katherine R. Smith et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway
- (2012) José M. Bravo-San Pedro et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
- (2012) Adriana Sánchez-Danés et al. EMBO Molecular Medicine
- Discovery, Structure–Activity Relationship, and Biological Evaluation of Noninhibitory Small Molecule Chaperones of Glucocerebrosidase
- (2012) Samarjit Patnaik et al. JOURNAL OF MEDICINAL CHEMISTRY
- Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, -Synuclein Accumulation, and Neurotoxicity
- (2012) M. Usenovic et al. JOURNAL OF NEUROSCIENCE
- The -Secretase-Derived C-Terminal Fragment of APP, C99, But Not A , Is a Key Contributor to Early Intraneuronal Lesions in Triple-Transgenic Mouse Hippocampus
- (2012) I. Lauritzen et al. JOURNAL OF NEUROSCIENCE
- Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
- (2012) Elisa Majounie et al. LANCET NEUROLOGY
- Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy
- (2012) A. Orsi et al. MOLECULAR BIOLOGY OF THE CELL
- Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
- (2012) Keiichi Inoue et al. Molecular Neurodegeneration
- Exosomal cell-to-cell transmission of alpha synuclein oligomers
- (2012) Karin M Danzer et al. Molecular Neurodegeneration
- Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
- (2012) J W Steele et al. MOLECULAR PSYCHIATRY
- An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
- (2012) Adam L. Hughes et al. NATURE
- Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
- (2012) Lei Liu et al. NATURE CELL BIOLOGY
- Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy
- (2012) Chinatsu Otomo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome
- (2012) Anne Grünewald et al. NEUROBIOLOGY OF AGING
- NP03, a novel low-dose lithium formulation, is neuroprotective in the YAC128 mouse model of Huntington disease
- (2012) Mahmoud A. Pouladi et al. NEUROBIOLOGY OF DISEASE
- SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
- (2012) E. Rubino et al. NEUROLOGY
- Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis
- (2012) T. Willinger et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Loss of P-type ATPase ATP13A2/PARK9 function induces general lysosomal deficiency and leads to Parkinson disease neurodegeneration
- (2012) B. Dehay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Synthetic zinc finger repressors reduce mutant huntingtin expression in the brain of R6/2 mice
- (2012) M. Garriga-Canut et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
- (2012) I.-F. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
- (2012) A. Roczniak-Ferguson et al. Science Signaling
- Amino acids and mTORC1: from lysosomes to disease
- (2012) Alejo Efeyan et al. TRENDS IN MOLECULAR MEDICINE
- Calcium homeostasis in aging neurons
- (2012) Vassiliki Nikoletopoulou et al. Frontiers in Genetics
- SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2011) Faisal Fecto ARCHIVES OF NEUROLOGY
- Identification and Characterization of Pharmacological Chaperones to Correct Enzyme Deficiencies in Lysosomal Storage Disorders
- (2011) Kenneth J. Valenzano et al. ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
- Autophagy and Aging
- (2011) David C. Rubinsztein et al. CELL
- Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
- (2011) Joseph R. Mazzulli et al. CELL
- The Beclin 1 network regulates autophagy and apoptosis
- (2011) R Kang et al. CELL DEATH AND DIFFERENTIATION
- LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
- (2011) Ha Nam Nguyen et al. Cell Stem Cell
- Endosome maturation
- (2011) Jatta Huotari et al. EMBO JOURNAL
- β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia
- (2011) Robert Tamayev et al. EMBO Molecular Medicine
- Regulation of Autophagy by Neuropathological Protein TDP-43
- (2011) Jayarama Krishnan Bose et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Implication of Ca2+in the Regulation of Replicative Life Span of Budding Yeast
- (2011) Ryohei Tsubakiyama et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a -Secretase-Independent Manner
- (2011) K. M. Neely et al. JOURNAL OF NEUROSCIENCE
- AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
- (2011) Joungmok Kim et al. NATURE CELL BIOLOGY
- Fighting neurodegeneration with rapamycin: mechanistic insights
- (2011) Jordi Bové et al. NATURE REVIEWS NEUROSCIENCE
- Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
- (2011) Lydia Alvarez-Erviti et al. NEUROBIOLOGY OF DISEASE
- Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS
- (2011) D. Ito et al. NEUROLOGY
- Combined Treatment with the Mood Stabilizers Lithium and Valproate Produces Multiple Beneficial Effects in Transgenic Mouse Models of Huntington's Disease
- (2011) Chi-Tso Chiu et al. NEUROPSYCHOPHARMACOLOGY
- Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons
- (2011) Janet van Eersel et al. PLoS One
- CNS expression of glucocerebrosidase corrects -synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
- (2011) S. P. Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
- (2011) R. Zoncu et al. SCIENCE
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo
- (2011) R Russo et al. Cell Death & Disease
- Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
- (2010) Lydia Alvarez-Erviti et al. ARCHIVES OF NEUROLOGY
- VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
- (2010) Emilie Tresse et al. Autophagy
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease
- (2010) C. Rose et al. HUMAN MOLECULAR GENETICS
- Disruption of endocytic trafficking in frontotemporal dementia with CHMP2B mutations
- (2010) Hazel Urwin et al. HUMAN MOLECULAR GENETICS
- AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
- (2010) Valérie Vingtdeux et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein impairs macroautophagy: implications for Parkinson’s disease
- (2010) Ashley R. Winslow et al. JOURNAL OF CELL BIOLOGY
- The risk of Parkinson’s disease in type 1 Gaucher disease
- (2010) Gilberto Bultron et al. JOURNAL OF INHERITED METABOLIC DISEASE
- Regulation of TDP-43 aggregation by phosphorylation andp62/SQSTM1
- (2010) Owen A. Brady et al. JOURNAL OF NEUROCHEMISTRY
- Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease
- (2010) C. Malagelada et al. JOURNAL OF NEUROSCIENCE
- Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
- (2010) S. J. Barmada et al. JOURNAL OF NEUROSCIENCE
- Cell-Produced -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival
- (2010) E. Emmanouilidou et al. JOURNAL OF NEUROSCIENCE
- The Cathepsin D (224C/T) Polymorphism Confers an Increased Risk to Develop Alzheimer's Disease in Men
- (2010) O. Albayrak et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
- (2010) Kathryn E. Wellen et al. MOLECULAR CELL
- Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease
- (2010) Erik Portelius et al. Molecular Neurodegeneration
- Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1
- (2010) Jaime N. Guzman et al. NATURE
- The origin of the autophagosomal membrane
- (2010) Sharon A. Tooze et al. NATURE CELL BIOLOGY
- Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
- (2010) Marta Martinez-Vicente et al. NATURE NEUROSCIENCE
- Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
- (2010) Jose A. Rodríguez-Navarro et al. NEUROBIOLOGY OF DISEASE
- Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
- (2010) Patricia Spilman et al. PLoS One
- Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
- (2010) E. Kickstein et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Beclin 1–VPS34 complex – at the crossroads of autophagy and beyond
- (2010) Sarah F. Funderburk et al. TRENDS IN CELL BIOLOGY
- Proton pump inhibition induces autophagy as a survival mechanism following oxidative stress in human melanoma cells
- (2010) M L Marino et al. Cell Death & Disease
- Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
- (2009) Eisuke Itakura et al. Autophagy
- Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation
- (2009) Hyunkyung Jeong et al. CELL
- The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
- (2009) J M Vicencio et al. CELL DEATH AND DIFFERENTIATION
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
- (2009) Christopher B. Newgard et al. Cell Metabolism
- Disease-causing mutations within the lysosomal integral membrane protein type 2 (LIMP-2) reveal the nature of binding to its ligand β-glucocerebrosidase
- (2009) Judith Blanz et al. HUMAN MOLECULAR GENETICS
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
- (2009) Ruben K. Dagda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ULK1·ATG13·FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
- (2009) Ian G. Ganley et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
- (2009) Jozsef Gal et al. JOURNAL OF NEUROCHEMISTRY
- Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus
- (2009) Daniel del Toro et al. MOLECULAR BIOLOGY OF THE CELL
- Acute dosing of latrepirdine (Dimebon™), a possible Alzheimer therapeutic, elevates extracellular amyloid-β levels in vitro and in vivo
- (2009) John W Steele et al. Molecular Neurodegeneration
- α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
- (2009) Aaron D Gitler et al. NATURE GENETICS
- Serines 13 and 16 Are Critical Determinants of Full-Length Human Mutant Huntingtin Induced Disease Pathogenesis in HD Mice
- (2009) Xiaofeng Gu et al. NEURON
- Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
- (2009) Xiaoju Wang et al. NEUROSCIENCE LETTERS
- Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein
- (2009) Barbara Monti et al. NEUROTOXICITY RESEARCH
- A Gene Network Regulating Lysosomal Biogenesis and Function
- (2009) Marco Sardiello et al. SCIENCE
- Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae
- (2009) Sandra Merz et al. GENOME BIOLOGY
- Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells
- (2008) Lars Rellin et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Structural basis of target recognition by Atg8/LC3 during selective autophagy
- (2008) Nobuo N. Noda et al. GENES TO CELLS
- Novel families of vacuolar amino acid transporters
- (2008) Takayuki Sekito et al. IUBMB LIFE
- Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
- (2008) Derek Narendra et al. JOURNAL OF CELL BIOLOGY
- Glucagon-like peptide 1 receptor stimulation by exendin-4 reverses key deficits in distinct rodent models of Parkinson's disease
- (2008) Alexander Harkavyi et al. Journal of Neuroinflammation
- Lack of Pathology in a Triple Transgenic Mouse Model of Alzheimer's Disease after Overexpression of the Anti-Apoptotic Protein Bcl-2
- (2008) T. T. Rohn et al. JOURNAL OF NEUROSCIENCE
- Atg8 Controls Phagophore Expansion during Autophagosome Formation
- (2008) Zhiping Xie et al. MOLECULAR BIOLOGY OF THE CELL
- The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
- (2008) Naonobu Fujita et al. MOLECULAR BIOLOGY OF THE CELL
- Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
- (2008) Eisuke Itakura et al. MOLECULAR BIOLOGY OF THE CELL
- Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- (2008) Andrea Williams et al. Nature Chemical Biology
- New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals
- (2008) L. Zecca et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
- Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of parkinson's disease
- (2007) Göran Bertilsson et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Cathepsin D expression is decreased in Alzheimer's disease fibroblasts
- (2006) Lorena Urbanelli et al. NEUROBIOLOGY OF AGING
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