IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation

Karyopherins in cancer

(2018) Tolga Çağatay et al.   CURRENT OPINION IN CELL BIOLOGY

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

NIT1 suppresses tumour proliferation by activating the TGFβ1–Smad2/3 signalling pathway in colorectal cancer

(2018) Chun Lin et al.   Cell Death & Disease

KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc

(2018) Jie Li et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Nuclear-cytoplasmic transport is a therapeutic target in myelofibrosis

(2018) Dongqing Yan et al.   CLINICAL CANCER RESEARCH

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Controlling the Gatekeeper: Therapeutic Targeting of Nuclear Transport

(2018) Friederike Kosyna et al.   Cells

Nuclear import of prototype foamy virus transactivator Bel1 is mediated by KPNA1, KPNA6 and KPNA7

(2017) Jihui Duan et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Alterations of the nuclear transport system in hepatocellular carcinoma – New basis for therapeutic strategies

(2017) Martin Beck et al.   JOURNAL OF HEPATOLOGY

RASAL2, a RAS GTPase-activating protein, inhibits stemness and epithelial–mesenchymal transition via MAPK/SOX2 pathway in bladder cancer

(2017) Ke Hui et al.   Cell Death & Disease

Exportin-5 Functions as an Oncogene and a Potential Therapeutic Target in Colorectal Cancer

(2016) Kunitoshi Shigeyasu et al.   CLINICAL CANCER RESEARCH

Recognition Elements in the Histone H3 and H4 Tails for Seven Different Importins

(2016) Michael Soniat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Proteomics of the SMAD (Suppressor of Mothers against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor SMAD-specific Importin

(2016) Roy Baas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies

(2016) Z A Hing et al.   LEUKEMIA

Targeting the Nuclear Import Receptor Kpn 1 as an Anticancer Therapeutic

(2016) P. J. van der Watt et al.   MOLECULAR CANCER THERAPEUTICS

XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer

(2016) Jimi Kim et al.   NATURE

Inhibition of KPNA4 attenuates prostate cancer metastasis

(2016) J Yang et al.   ONCOGENE

Importins and exportins as therapeutic targets in cancer

(2016) Amit Mahipal et al.   PHARMACOLOGY & THERAPEUTICS

Loss of RasGAP Tumor Suppressors Underlies the Aggressive Nature of Luminal B Breast Cancers

(2016) Sarah Naomi Olsen et al.   Cancer Discovery

KPNA2 is a nuclear export protein that contributes to aberrant localisation of key proteins and poor prognosis of breast cancer

(2015) A T Alshareeda et al.   BRITISH JOURNAL OF CANCER

Karyopherin alpha 2 is a novel prognostic marker and a potential therapeutic target for colon cancer

(2015) Yu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification of Target Genes Regulated by KSHV miRNAs in KSHV-Infected Lymphoma Cells

(2015) Liangliang Quan et al.   PATHOLOGY & ONCOLOGY RESEARCH

Expression, function, and targeting of the nuclear exporter chromosome region maintenance 1 (CRM1) protein

(2015) Jo Ishizawa et al.   PHARMACOLOGY & THERAPEUTICS

Macromolecular transport between the nucleus and the cytoplasm: Advances in mechanism and emerging links to disease

(2014) Elizabeth J. Tran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inhibition of the nuclear transporter, Kpnβ1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells

(2014) Liselotte Angus et al.   CARCINOGENESIS

Clinical translation of nuclear export inhibitors in cancer

(2014) William T. Senapedis et al.   SEMINARS IN CANCER BIOLOGY

Biological Significance of the Importin-β Family-Dependent Nucleocytoplasmic Transport Pathways

(2014) Makoto Kimura et al.   TRAFFIC

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

(2013) K. Kojima et al.   BLOOD

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias

(2013) C. J. Walker et al.   BLOOD

RASAL2: Wrestling in the Combat of Ras Activation

(2013) Jia Shen et al.   CANCER CELL

The RasGAP Gene, RASAL2, Is a Tumor and Metastasis Suppressor

(2013) Sara Koenig McLaughlin et al.   CANCER CELL

CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications

(2013) Y-T Tai et al.   LEUKEMIA

SeqNLS: Nuclear Localization Signal Prediction Based on Frequent Pattern Mining and Linear Motif Scoring

(2013) Jhih-rong Lin et al.   PLoS One

Quantitative Proteomics Reveals Regulation of Karyopherin Subunit Alpha-2 (KPNA2) and Its Potential Novel Cargo Proteins in Nonsmall Cell Lung Cancer

(2012) Chun-I Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo

(2009) S. C. Mutka et al.   CANCER RESEARCH

Karyopherin β3: A new cellular target for the HPV-16 E5 oncoprotein

(2008) Ewa Krawczyk et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Karyopherin proteins, Crm1 and Karyopherin β1, are overexpressed in cervical cancer and are critical for cancer cell survival and proliferation

(2008) Pauline J. van der Watt et al.   INTERNATIONAL JOURNAL OF CANCER