Binding mechanisms of half-sandwich Rh(III) and Ru(II) arene complexes on human serum albumin: a comparative study

Structure–activity relationships for ruthenium and osmium anticancer agents – towards clinical development

(2018) Samuel M. Meier-Menches et al.   CHEMICAL SOCIETY REVIEWS

Anticancer Activity and Catalytic Potential of Ruthenium(II)–Arene Complexes with N,O-Donor Ligands

(2018) Mohammad Mehdi Haghdoost et al.   INORGANIC CHEMISTRY

Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions

(2018) Irwin Cassells et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Comparative solution equilibrium and structural studies of half-sandwich ruthenium(II)(η 6 -toluene) complexes of picolinate derivatives

(2018) Jelena M. Poljarević et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Structural and solution equilibrium studies on half-sandwich organorhodium complexes of (N,N) donor bidentate ligands

(2018) János P. Mészáros et al.   NEW JOURNAL OF CHEMISTRY

Dimetallic Ru(II) arene complexes appended on bis-salicylaldimine induce cancer cell death and suppress invasion via p53-dependent signaling

(2018) Faiz-Ur Rahman et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC–ICP–MS

(2018) Matthias H. M. Klose et al.   MONATSHEFTE FUR CHEMIE

Transition Metal Complexes and Photodynamic Therapy from a Tumor-Centered Approach: Challenges, Opportunities, and Highlights from the Development of TLD1433

(2018) Susan Monro et al.   CHEMICAL REVIEWS

Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O,N) donor bidentate ligands

(2017) Orsolya Dömötör et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation

(2017) Gabriela E. Davey et al.   Nature Communications

Allosteric cross-talk in chromatin can mediate drug-drug synergy

(2017) Zenita Adhireksan et al.   Nature Communications

Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior

(2016) Carmen M. Hackl et al.   CHEMISTRY-A EUROPEAN JOURNAL

The development of RAPTA compounds for the treatment of tumors

(2016) Benjamin S. Murray et al.   COORDINATION CHEMISTRY REVIEWS

Towards targeting anticancer drugs: ruthenium(ii)–arene complexes with biologically active naphthoquinone-derived ligand systems

(2016) Mario Kubanik et al.   DALTON TRANSACTIONS

Metal-based drugs that break the rules

(2016) Claire S. Allardyce et al.   DALTON TRANSACTIONS

X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism

(2016) Aleksandar Bijelic et al.   JOURNAL OF MEDICINAL CHEMISTRY

η6-(2-phenoxyethanol) ruthenium(II)-complexes of 2,2′-bipyridine and its derivatives: Solution speciation and kinetic behaviour

(2016) Guilherme Nogueira et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Complex formation between [(η 6 - p -cym)Ru(H 2 O) 3 ] 2+ and oligopeptides containing three histidyl moieties

(2016) Zsolt Bihari et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Multispectroscopic Investigation of the Interaction Between two Ruthenium(II) Arene Complexes of Curcumin Analogs and Human Serum Albumin

(2015) Shan Huang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone

(2015) Éva A. Enyedy et al.   JOURNAL OF COORDINATION CHEMISTRY

Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2ʹ-bipyridine and ethylenediamine and their interaction with human serum albumin

(2015) Éva A. Enyedy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

[(η 6 - p -cym)Ru(H 2 O) 3 ] 2+ binding capability of N-methylimidazole to model the interaction between the metal ion and surface histidine residues of peptides

(2015) Zsolt Bihari et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins

(2014) Éva A. Enyedy et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: Synthesis, solution speciation and bioactivity

(2014) Orsolya Dömötör et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity

(2014) Zenita Adhireksan et al.   Nature Communications

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

(2013) Wolfgang Kandioller et al.   CHEMICAL COMMUNICATIONS

Exploration of the medical periodic table: towards new targets

(2013) Nicolas P. E. Barry et al.   CHEMICAL COMMUNICATIONS

Increasing the Bioavailability of RuIIIAnticancer Complexes through Hydrophobic Albumin Interactions

(2013) Michael I. Webb et al.   CHEMISTRY-A EUROPEAN JOURNAL

Bioactive iridium and rhodium complexes as therapeutic agents

(2013) Chung-Hang Leung et al.   COORDINATION CHEMISTRY REVIEWS

Opening the lid on piano-stool complexes: An account of ruthenium(II)–arene complexes with medicinal applications

(2013) Alexey A. Nazarov et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

A Dual Anchoring Strategy for the Localization and Activation of Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology

(2013) Jeremy M. Zimbron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Solution equilibrium studies of anticancer ruthenium(II)-η6-p-cymene complexes of pyridinecarboxylic acids

(2013) Éva Sija et al.   POLYHEDRON

Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents

(2013) Samuel M. Meier et al.   Chemical Science

The interaction of platinum-based drugs with native biologically relevant proteins

(2012) Christine Brauckmann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure–activity relationships and stability studies on RuII(arene) anticancer complexes with biologically active ligands

(2012) Andrea Kurzwernhart et al.   DALTON TRANSACTIONS

Rhodium(III) and iridium(III) complexes as anticancer agents

(2012) Yvonne Geldmacher et al.   INORGANICA CHIMICA ACTA

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

(2012) Orsolya Dömötör et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Interaction of [Ru(η6-p-cym)(H2O)3]2+ with citrate and tricarballate ions in aqueous solution; X-ray crystal structure of novel half-sandwich Ru(II)-citrato complexes

(2012) Linda Bíró et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

X-ray Absorption Spectroscopy of an Investigational Anticancer Gallium(III) Drug: Interaction with Serum Proteins, Elemental Distribution Pattern, and Coordination of the Compound in Tissue

(2012) Alfred A. Hummer et al.   JOURNAL OF MEDICINAL CHEMISTRY

Half-sandwich organometallic complexes with stereogenic metal centres: Synthesis and characterization of diastereomeric [(ηn-ring)M(Aa)X] (Aa = α-amino carboxylate) compounds

(2012) Daniel Carmona et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Interaction between [Ru(η6-p-cym)(H2O)3]2+ and dl-serine or dl-isoserine: The role of the side chain alcoholic OH group in metal ion binding

(2012) Linda Bíró et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies

(2011) Éva A. Enyedy et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Ruthenium Antimetastasis Agent Forms Specific Histone Protein Adducts in the Nucleosome Core

(2011) Bin Wu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Hydrolytic behaviour and chloride ion binding capability of [Ru(η6-p-cym)(H2O)3]2+: a solution equilibrium study

(2011) Linda Bíró et al.   DALTON TRANSACTIONS

Impact of albumin on drug delivery — New applications on the horizon

(2011) Bakheet Elsadek et al.   JOURNAL OF CONTROLLED RELEASE

Complex formation between Ru(η6-p-cym)(H2O)3]2+ and (O,O) donor ligands with biological relevance in aqueous solution

(2010) Linda Bíró et al.   DALTON TRANSACTIONS

Incorporation of organometallic Ru complexes into apo-ferritin cage

(2010) Yusuke Takezawa et al.   DALTON TRANSACTIONS

Interactions of arene–Ru(II)–chloroquine complexes of known antimalarial and antitumor activity with human serum albumin (HSA) and transferrin

(2010) Alberto Martínez et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Stability, accumulation and cytotoxicity of an albumin-cisplatin adduct

(2010) Charlotte Møller et al.   Metallomics

Rational Design of an Organometallic Glutathione Transferase Inhibitor

(2009) Wee Han Ang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arene Control over Thiolate to Sulfinate Oxidation in Albumin by Organometallic Ruthenium Anticancer Complexes

(2009) Wenbing Hu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel half-sandwich Ru(II)-hydroxamate complexes: synthesis, characterization and equilibrium study in aqueous solution

(2009) Péter Buglyó et al.   DALTON TRANSACTIONS

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs

(2009) Sabine H. van Rijt et al.   DRUG DISCOVERY TODAY

The serum protein binding of pharmacologically active gallium(III) compounds assessed by hyphenated CE-MS techniques

(2009) Michael Groessl et al.   ELECTROPHORESIS

In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model

(2009) A. Bergamo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

The ruthenium(II)–arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53–JNK pathways

(2008) Soumya Chatterjee et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Human serum albumin interaction with oxaliplatin studied by capillary isoelectric focusing with the whole column imaging detection and spectroscopic method

(2008) Tibebe Lemma et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Metal-Ligand Exchange Kinetics in Platinum and Ruthenium Complexes

(2008) By Jan Reedijk  

Studies on the reactivity of organometallic Ru–, Rh– and Os–pta complexes with DNA model compounds

(2007) Antoine Dorcier et al.   JOURNAL OF INORGANIC BIOCHEMISTRY