The Impact of Iron Overload and Ferroptosis on Reproductive Disorders in Humans: Implications for Preeclampsia

Randomized controlled trial of low (5%) versus ultralow (2%) oxygen for extended culture using bipronucleate and tripronucleate human preimplantation embryos

(2018) Daniel J. Kaser et al.   FERTILITY AND STERILITY

Compromised JMJD6 Histone Demethylase Activity Affects VHL Gene Repression in Preeclampsia

(2018) Sruthi Alahari et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Increased serum iron in preeclamptic women is likely due to low hepcidin levels

(2018) Fernanda Brunacci et al.   NUTRITION RESEARCH

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The Development of the Concept of Ferroptosis

(2018) Tal Hirschhorn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery

(2018) Olivia J. Holland et al.   Cell Death & Disease

Impaired mitochondrial fusion, autophagy, biogenesis and dysregulated lipid metabolism is associated with preeclampsia

(2017) Xiaobo Zhou et al.   EXPERIMENTAL CELL RESEARCH

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

(2017) Mihaela Pavličev et al.   GENOME RESEARCH

Estimating the Cost of Preeclampsia in the Healthcare SystemNovelty and Significance

(2017) Aimée Fox et al.   HYPERTENSION

Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia

(2017) Jacquelyn M. Powers et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Iron transport proteins: Gateways of cellular and systemic iron homeostasis

(2017) Mitchell D. Knutson   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Parturition: Nothing More Than a Delayed Menstruation

(2017) Mihaela Pavlicev et al.   Reproductive Sciences

Iron Supplementation during Pregnancy and Infancy: Uncertainties and Implications for Research and Policy

(2017) Patsy Brannon et al.   Nutrients

The placenta as a model for understanding the origin and evolution of vertebrate organs

(2017) Oliver W. Griffith et al.   Nature Ecology & Evolution

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Placental Ischemia and Resultant Phenotype in Animal Models of Preeclampsia

(2016) Babbette LaMarca et al.   CURRENT HYPERTENSION REPORTS

Seminal fluid and fertility in women

(2016) Sarah A. Robertson et al.   FERTILITY AND STERILITY

Comparative analysis of iron status and other hematological parameters in preeclampsia†

(2016) César Homero Gutierrez-Aguirre et al.   Hematology

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women

(2016) Caroline B. van den Berg et al.   Proteomics Clinical Applications

Animal Models to Study Placental Development and Function throughout Normal and Dysfunctional Human Pregnancy

(2016) Peta Grigsby   SEMINARS IN REPRODUCTIVE MEDICINE

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

(2016) Alexander R. Bogdan et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

Intestinal DMT1 is critical for iron absorption in the mouse but is not required for the absorption of copper or manganese

(2015) Ali Shawki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A novel inflammatory pathway mediating rapid hepcidin-independent hypoferremia

(2015) C. Guida et al.   BLOOD

SLC39A14 Is Required for the Development of Hepatocellular Iron Overload in Murine Models of Hereditary Hemochromatosis

(2015) Supak Jenkitkasemwong et al.   Cell Metabolism

Exposure to Experimental Preeclampsia in Mice Enhances the Vascular Response to Future Injury

(2015) D. Pruthi et al.   HYPERTENSION

Nitric Oxide and Reactive Oxygen Species in the Pathogenesis of Preeclampsia

(2015) Keiichi Matsubara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function

(2015) Samira Lakhal-Littleton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal zinc deficiency during pregnancy elevates the risks of fetal growth restriction: a population-based birth cohort study

(2015) Hua Wang et al.   Scientific Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Resistance of Ferroportin to Hepcidin Binding causes Exocrine Pancreatic Failure and Fatal Iron Overload

(2014) Sandro Altamura et al.   Cell Metabolism

Ferritin light-chain subunits: key elements for the electron transfer across the protein cage

(2014) Unai Carmona et al.   CHEMICAL COMMUNICATIONS

Association of oral iron supplementation with birth outcomes in non-anaemic South Indian pregnant women

(2014) L Shastri et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants

(2014) Tanja Jaeggi et al.   GUT

Is the level of maternal serum prohepcidin associated with preeclampsia?

(2014) Candan Iltemir Duvan et al.   HYPERTENSION IN PREGNANCY

Oxygen metabolism in human placenta mitochondria

(2014) J. Bustamante et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Trophoblast syncytialisation necessitates mitochondrial function through estrogen-related receptor-  activation

(2014) D. Poidatz et al.   MOLECULAR HUMAN REPRODUCTION

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

(2014) Joseph D. Mancias et al.   NATURE

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

(2014) Antonio Ayala et al.   Oxidative Medicine and Cellular Longevity

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ischemic placental disease: A unifying concept for preeclampsia, intrauterine growth restriction, and placental abruption

(2014) Cande V. Ananth   SEMINARS IN PERINATOLOGY

Hepcidin and Iron Homeostasis during Pregnancy

(2014) Mary Koenig et al.   Nutrients

The IRP/IRE system in vivo: insights from mouse models

(2014) Nicole Wilkinson et al.   Frontiers in Pharmacology

Functional properties of human ferroportin, a cellular iron exporter reactive also with cobalt and zinc

(2013) Colin J. Mitchell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Iron and Copper in Mitochondrial Diseases

(2013) Wenjing Xu et al.   Cell Metabolism

The effect of two distinct levels of oxygen concentration on embryo development in a sibling oocyte study

(2013) Esti Kasterstein et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Each Member of the Poly-r(C)-binding Protein 1 (PCBP) Family Exhibits Iron Chaperone Activity toward Ferritin

(2013) Sebastien Leidgens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preeclampsia and uteroplacental acute atherosis: immune and inflammatory factors

(2013) Anne Cathrine Staff et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Comparative Proteomics Analysis Suggests that Placental Mitochondria are Involved in the Development of Pre-Eclampsia

(2013) Zhonghua Shi et al.   PLoS One

Intestinal HIF2  promotes tissue-iron accumulation in disorders of iron overload with anemia

(2013) E. R. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol

(2012) Y. Gottlieb et al.   HAEMATOLOGICA

Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice

(2012) Zhuzhen Zhang et al.   HEPATOLOGY

Apolipoprotein E Genotypes, Lipid Peroxidation, and Antioxidant Status among Mild and Severe Preeclamptic Women from Western Iran: Protective Role of Apolipoprotein ϵ2 Allele in Severe Preeclampsia

(2012) Reza Ahmadi et al.   HYPERTENSION IN PREGNANCY

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease

(2011) Michael Li-Hsuan Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation of the HIF Prolyl Hydroxylase by the Iron Chaperones PCBP1 and PCBP2

(2011) Anjali Nandal et al.   Cell Metabolism

Immunology of Pre-Eclampsia

(2010) Christopher W. G. Redman et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Iron status parameters in preeclamptic women

(2010) Imran A. Siddiqui et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Evolution of invasive placentation with special reference to non-human primates

(2010) Anthony M. Carter et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Human Frataxin Is an Allosteric Switch That Activates the Fe−S Cluster Biosynthetic Complex

(2010) Chi-Lin Tsai et al.   BIOCHEMISTRY

Cytosolic and mitochondrial ferritins in the regulation of cellular iron homeostasis and oxidative damage

(2010) Paolo Arosio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis

(2010) W. Chen et al.   BLOOD

Dysfunction of the heme recycling system in heme oxygenase 1-deficient mice: effects on macrophage viability and tissue iron distribution

(2010) G. Kovtunovych et al.   BLOOD

Hereditary Hemochromatosis: Pathogenesis, Diagnosis, and Treatment

(2010) Antonello Pietrangelo   GASTROENTEROLOGY

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

(2010) S. Marro et al.   HAEMATOLOGICA

Preeclampsia and Cardiovascular Disease Death

(2010) Morgana L. Mongraw-Chaffin et al.   HYPERTENSION

Hypoxia-mediated biological control

(2010) Jessica Cassavaugh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Evidence for distinct preterm and term phenotypes of preeclampsia

(2010) Julie K. Phillips et al.   Journal of Maternal-Fetal & Neonatal Medicine

The Fowler Syndrome-Associated Protein FLVCR2 Is an Importer of Heme

(2010) S. P. Duffy et al.   MOLECULAR AND CELLULAR BIOLOGY

Maternal hemoglobin level and fetal outcome at low and high altitudes

(2009) Gustavo F. Gonzales et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Iron Homeostasis and Its Interaction with Prolyl Hydroxylases

(2009) David R. Mole   ANTIOXIDANTS & REDOX SIGNALING

Hereditary hemochromatosis due to resistance to hepcidin: high hepcidin concentrations in a family with C326S ferroportin mutation

(2009) R. L. Sham et al.   BLOOD

Beyond oxygen: complex regulation and activity of hypoxia inducible factors in pregnancy

(2009) K. G. Pringle et al.   HUMAN REPRODUCTION UPDATE

Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant

(2009) M. L.-H. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

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Splice Mutation in the Iron-Sulfur Cluster Scaffold Protein ISCU Causes Myopathy with Exercise Intolerance

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Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE