Persisters—as elusive as ever

Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells

(2016) Yingying Pu et al.   MOLECULAR CELL

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

(2016) Nityananda Chowdhury et al.   Scientific Reports

Composition of the outgrowth medium modulates wake-up kinetics and ampicillin sensitivity of stringent and relaxed Escherichia coli

(2016) Vallo Varik et al.   Scientific Reports

Persister formation in Staphylococcus aureus is associated with ATP depletion

(2016) Brian P. Conlon et al.   Nature Microbiology

Frequency of antibiotic application drives rapid evolutionary adaptation of Escherichia coli persistence

(2016) Bram Van den Bergh et al.   Nature Microbiology

Persister Heterogeneity Arising from a Single Metabolic Stress

(2015) Stephanie M. Amato et al.   CURRENT BIOLOGY

Phenotypic Diversity as a Mechanism to Exit Cellular Dormancy

(2015) Alexander Sturm et al.   CURRENT BIOLOGY

Microbial bet-hedging: the power of being different

(2015) Ard Jan Grimbergen et al.   CURRENT OPINION IN MICROBIOLOGY

Viable but Nonculturable and Persister Cells Coexist Stochastically and Are Induced by Human Serum

(2015) M. Ayrapetyan et al.   INFECTION AND IMMUNITY

NonstableStaphylococcus aureusSmall-Colony Variants Are Induced by Low pH and Sensitized to Antimicrobial Therapy by Phagolysosomal Alkalinization

(2015) Nadja Leimer et al.   JOURNAL OF INFECTIOUS DISEASES

Obg and Membrane Depolarization Are Part of a Microbial Bet-Hedging Strategy that Leads to Antibiotic Tolerance

(2015) Natalie Verstraeten et al.   MOLECULAR CELL

HipBA–promoter structures reveal the basis of heritable multidrug tolerance

(2015) Maria A. Schumacher et al.   NATURE

Bridging the gap between viable but non-culturable and antibiotic persistent bacteria

(2015) Mesrop Ayrapetyan et al.   TRENDS IN MICROBIOLOGY

RNA Futile Cycling in Model Persisters Derived from MazF Accumulation

(2015) W. W. K. Mok et al.   mBio

Genetic Basis of Persister Tolerance to Aminoglycosides in Escherichia coli

(2015) Yue Shan et al.   mBio

Cell Differentiation in a Bacillus thuringiensis Population during Planktonic Growth, Biofilm Formation, and Host Infection

(2015) Emilie Verplaetse et al.   mBio

Selective Target Inactivation Rather than Global Metabolic Dormancy Causes Antibiotic Tolerance in Uropathogens

(2014) Lee W. Goneau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antagonism between Bacteriostatic and Bactericidal Antibiotics Is Prevalent

(2014) Paolo S. Ocampo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy

(2014) Beatrice Claudi et al.   CELL

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics

(2014) Bruce R Levin et al.   CURRENT OPINION IN MICROBIOLOGY

Phenotypic bistability in Escherichia coli's central carbon metabolism

(2014) O. Kotte et al.   Molecular Systems Biology

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Senescence, dormancy and tillering in perennial C4 grasses

(2014) Gautam Sarath et al.   PLANT SCIENCE

Novel Protocol for Persister Cells Isolation

(2014) Silvia J. Cañas-Duarte et al.   PLoS One

Nutrient Transitions Are a Source of Persisters in Escherichia coli Biofilms

(2014) Stephanie M. Amato et al.   PLoS One

Systematic Production of Inactivating and Non-Inactivating Suppressor Mutations at the relA Locus That Compensate the Detrimental Effects of Complete spoT Loss and Affect Glycogen Content in Escherichia coli

(2014) Manuel Montero et al.   PLoS One

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

The importance of the viable but non-culturable state in human bacterial pathogens

(2014) Laam Li et al.   Frontiers in Microbiology

Promoter activity dynamics in the lag phase of Escherichia coli

(2013) Daniel Madar et al.   BMC Systems Biology

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Microbial Persistence and the Road to Drug Resistance

(2013) Nadia R. Cohen et al.   Cell Host & Microbe

Persisters and beyond: Mechanisms of phenotypic drug resistance and drug tolerance in bacteria

(2013) Jemila C. Kester et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Thirty years of viable but nonculturable state research: Unsolved molecular mechanisms

(2013) Daniela Pinto et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Tolerance of Escherichia coli to Fluoroquinolone Antibiotics Depends on Specific Components of the SOS Response Pathway

(2013) A. Theodore et al.   GENETICS

Metabolic Control of Persister Formation in Escherichia coli

(2013) Stephanie M. Amato et al.   MOLECULAR CELL

Activated ClpP kills persisters and eradicates a chronic biofilm infection

(2013) B. P. Conlon et al.   NATURE

Understanding, predicting and manipulating the genotypic evolution of antibiotic resistance

(2013) Adam C. Palmer et al.   NATURE REVIEWS GENETICS

Ribosome-targeting antibiotics and mechanisms of bacterial resistance

(2013) Daniel N. Wilson   NATURE REVIEWS MICROBIOLOGY

Cell Death from Antibiotics Without the Involvement of Reactive Oxygen Species

(2013) Y. Liu et al.   SCIENCE

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Dynamic Persistence of Antibiotic-Stressed Mycobacteria

(2013) Y. Wakamoto et al.   SCIENCE

Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in Staphylococcus aureus

(2013) Paul J. T. Johnson et al.   PLoS Genetics

Bacterial Persistence and Toxin-Antitoxin Loci

(2012) Kenn Gerdes et al.   Annual Review of Microbiology

Role of Oxidative Stress in Persister Tolerance

(2012) Yanxia Wu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comprehensive comparative-genomic analysis of Type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

(2012) Kira S Makarova et al.   Biology Direct

Staphylococcus aureus Persisters Tolerant to Bactericidal Antibiotics

(2012) Sabrina Lechner et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Large mutational target size for rapid emergence of bacterial persistence

(2012) H. S. Girgis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patterns of Evolutionary Conservation of Essential Genes Correlate with Their Compensability

(2012) Tobias Bergmiller et al.   PLoS Genetics

Toxin-Antitoxin Systems Are Important for Niche-Specific Colonization and Stress Resistance of Uropathogenic Escherichia coli

(2012) J. Paul Norton et al.   PLoS Pathogens

Bet hedging or not? A guide to proper classification of microbial survival strategies

(2011) Imke G. de Jong et al.   BIOESSAYS

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Persistence: mechanisms for triggering and enhancing phenotypic variability

(2011) NQ Balaban   CURRENT OPINION IN GENETICS & DEVELOPMENT

Heterogeneous bacterial persisters and engineering approaches to eliminate them

(2011) Kyle R Allison et al.   CURRENT OPINION IN MICROBIOLOGY

Age of Inoculum Strongly Influences Persister Frequency and Can Mask Effects of Mutations Implicated in Altered Persistence

(2011) H. Luidalepp et al.   JOURNAL OF BACTERIOLOGY

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth

(2011) Irit Shachrai et al.   MOLECULAR CELL

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria

(2011) D. Nguyen et al.   SCIENCE

Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters

(2011) I. Keren et al.   mBio

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

The Frequency of Persisters in Escherichia coli Reflects the Kinetics of Awakening from Dormancy

(2010) A. Joers et al.   JOURNAL OF BACTERIOLOGY

Cost of Unneeded Proteins in E. coli Is Reduced after Several Generations in Exponential Growth

(2010) Irit Shachrai et al.   MOLECULAR CELL

Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence

(2010) Eitan Rotem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Two Novel Point Mutations in Clinical Staphylococcus aureus Reduce Linezolid Susceptibility and Switch on the Stringent Response to Promote Persistent Infection

(2010) Wei Gao et al.   PLoS Pathogens

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel persistence genes inPseudomonas aeruginosaidentified by high-throughput screening

(2009) Valerie N. De Groote et al.   FEMS MICROBIOLOGY LETTERS

SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli

(2009) Tobias Dörr et al.   PLoS Genetics

Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli

(2008) S. Hansen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cell division in Escherichia coli cultures monitored at single cell resolution

(2008) Johanna Roostalu et al.   BMC MICROBIOLOGY