Ribosome-targeting antibiotics and mechanisms of bacterial resistance

Orthoformimycin, a Selective Inhibitor of Bacterial Translation Elongation from Streptomyces Containing an Unusual Orthoformate

(2013) Sonia I. Maffioli et al.   ACS Chemical Biology

Structural Basis of the Translational Elongation Cycle

(2013) Rebecca M. Voorhees et al.   Annual Review of Biochemistry

Phosphorylation of chloramphenicol by a recombinant protein Yhr2 from Streptomyces avermitilis MA4680

(2013) Thangamani Rajesh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structures of the human and Drosophila 80S ribosome

(2013) Andreas M. Anger et al.   NATURE

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Coordinated conformational and compositional dynamics drive ribosome translocation

(2013) Jin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis

(2013) L. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome

(2013) E. Svidritskiy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible

(2013) Pulkit Gupta et al.   Nature Communications

Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)

(2013) Wen Li et al.   Nature Communications

The Genetic Environment of thecfrGene and the Presence of Other Mechanisms Account for the Very High Linezolid Resistance of Staphylococcus epidermidis Isolate 426-3147L

(2012) Jacqueline LaMarre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic

(2012) Trudy H. Grossman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selective Protein Synthesis by Ribosomes with a Drug-Obstructed Exit Tunnel

(2012) Krishna Kannan et al.   CELL

Suppression of premature termination codons as a therapeutic approach

(2012) Kim M. Keeling et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Unraveling the dynamics of ribosome translocation

(2012) Jin Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Elements of ribosomal drug resistance and specificity

(2012) Gregor M Blaha et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and functional characterization of the bacterial translocation inhibitor GE82832

(2012) Letizia Brandi et al.   FEBS LETTERS

The Antibiotic Thermorubin Inhibits Protein Synthesis by Binding to Inter-Subunit Bridge B2a of the Ribosome

(2012) David Bulkley et al.   JOURNAL OF MOLECULAR BIOLOGY

Capreomycin susceptibility is increased by TlyA-directed 2′-O-methylation on both ribosomal subunits

(2012) Tanakarn Monshupanee et al.   MOLECULAR MICROBIOLOGY

A new understanding of the decoding principle on the ribosome

(2012) Natalia Demeshkina et al.   NATURE

Allosteric control of the ribosome by small-molecule antibiotics

(2012) Leyi Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The antibiotic Furvina® targets the P-site of 30S ribosomal subunits and inhibits translation initiation displaying start codon bias

(2012) Attilio Fabbretti et al.   NUCLEIC ACIDS RESEARCH

Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin

(2012) T. Matt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

(2012) G. Cox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for TetM-mediated tetracycline resistance

(2012) A. Donhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics that bind to the A site of the large ribosomal subunit can induce mRNA translocation

(2012) D. N. Ermolenko et al.   RNA

The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens

(2012) K. J. Forsberg et al.   SCIENCE

Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling

(2012) X. Guo et al.   Open Biology

Antibiotics in development targeting protein synthesis

(2011) Joyce A. Sutcliffe   Annals of the New York Academy of Sciences

Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action

(2011) Krishna Kannan et al.   Annals of the New York Academy of Sciences

On the specificity of antibiotics targeting the large ribosomal subunit

(2011) Daniel N. Wilson   Annals of the New York Academy of Sciences

Linezolid, the first oxazolidinone antibacterial agent

(2011) Karen L. Leach et al.   Annals of the New York Academy of Sciences

Inactivation of the Indigenous Methyltransferase RlmN in Staphylococcus aureus Increases Linezolid Resistance

(2011) Jacqueline M. LaMarre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Low Fitness Cost of the Multidrug Resistance Genecfr

(2011) Jacqueline M. LaMarre et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Basis for the Selectivity of Antituberculosis Compounds Capreomycin and Viomycin

(2011) Rashid Akbergenov et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ribosome as a molecular machine: the mechanism of tRNA–mRNA movement in translocation

(2011) Marina V. Rodnina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations

(2011) Dewan S Billal et al.   BMC GENOMICS

Sparsomycin-Linezolid Conjugates Can Promote Ribosomal Translocation

(2011) Shibo Li et al.   CHEMBIOCHEM

Differential Effects of Thiopeptide and Orthosomycin Antibiotics on Translational GTPases

(2011) Aleksandra Mikolajka et al.   CHEMISTRY & BIOLOGY

Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase

(2011) Gesa Volkers et al.   FEBS LETTERS

Antibiotics in the clinical pipeline in 2011

(2011) Mark S Butler et al.   JOURNAL OF ANTIBIOTICS

Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins

(2011) Triinu Siibak et al.   MOLECULAR MICROBIOLOGY

Antibiotic resistance is ancient

(2011) Vanessa M. D’Costa et al.   NATURE

Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit

(2011) M. J. Belousoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic 60S Ribosomal Subunit in Complex with Initiation Factor 6

(2011) S. Klinge et al.   SCIENCE

The Structure of the Eukaryotic Ribosome at 3.0 A Resolution

(2011) A. Ben-Shem et al.   SCIENCE

Aminoglycoside modifying enzymes

(2010) Maria S. Ramirez et al.   DRUG RESISTANCE UPDATES

Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistance

(2010) Varvara Pokrovskaya et al.   Expert Opinion on Drug Discovery

Thiazolyl Peptide Antibiotic Biosynthesis: A Cascade of Post-translational Modifications on Ribosomal Nascent Proteins

(2010) Christopher T. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Origins and Evolution of Antibiotic Resistance

(2010) J. Davies et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Last of the multidrug transporters

(2010) Hendrik W. van Veen   NATURE

Structure of a cation-bound multidrug and toxic compound extrusion transporter

(2010) Xiao He et al.   NATURE

Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites

(2010) Andreas H. Ratje et al.   NATURE

Chemical decay of an antibiotic inverts selection for resistance

(2010) Adam C Palmer et al.   Nature Chemical Biology

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

Call of the wild: antibiotic resistance genes in natural environments

(2010) Heather K. Allen et al.   NATURE REVIEWS MICROBIOLOGY

The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome

(2010) Robin E Stanley et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

(2010) T. Auerbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

(2010) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the structures of several antibiotics bound to the bacterial ribosome

(2010) D. Bulkley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

(2010) J. Rabl et al.   SCIENCE

Recent Advances in the Chemistry and Biology of Naturally Occurring Antibiotics

(2009) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui

(2009) G. Gurel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SnapShot: Antibiotic Inhibition of Protein Synthesis I

(2009) Daniel Sohmen et al.   CELL

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Selection of Small Peptides, Inhibitors of Translation

(2009) Beatriz Llano-Sotelo et al.   JOURNAL OF MOLECULAR BIOLOGY

Programmed drug-dependent ribosome stalling

(2009) Haripriya Ramu et al.   MOLECULAR MICROBIOLOGY

Aminoglycoside activity observed on single pre-translocation ribosome complexes

(2009) Michael B Feldman et al.   Nature Chemical Biology

Distinct functions of elongation factor G in ribosome recycling and translocation

(2009) A. Savelsbergh et al.   RNA

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

(2009) A. M. B. Giessing et al.   RNA

Structural Insight into Nascent Polypeptide Chain-Mediated Translational Stalling

(2009) B. Seidelt et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition

(2008) T. Siibak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An O-Phosphotransferase Catalyzes Phosphorylation of Hygromycin A in the Antibiotic-Producing Organism Streptomyces hygroscopicus

(2008) V. Dhote et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Transcriptional and Translational Control of the mlr Operon, Which Confers Resistance to Seven Classes of Protein Synthesis Inhibitors

(2008) L. K. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug resistant to extensively drug resistant tuberculosis: What is next?

(2008) Amita Jain et al.   JOURNAL OF BIOSCIENCES

Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit∥

(2008) Joseph A. Ippolito et al.   JOURNAL OF MEDICINAL CHEMISTRY

Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome

(2008) Xabier Agirrezabala et al.   MOLECULAR CELL

Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin

(2008) Joerg M. Harms et al.   MOLECULAR CELL

Spontaneous Intersubunit Rotation in Single Ribosomes

(2008) Peter V. Cornish et al.   MOLECULAR CELL

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

(2008) D. N. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of ratcheted ribosomes with tRNAs in hybrid states

(2008) P. Julian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for hygromycin B inhibition of protein biosynthesis

(2008) M. A. Borovinskaya et al.   RNA