期刊
CURRENT OPINION IN MICROBIOLOGY
卷 21, 期 -, 页码 18-21出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2014.06.016
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资金
- US National Institutes of General Medical Science [GM098175]
- Hesselman Fund
- Swedish Research Council junior investigator grant [2012-3564]
We postulate that phenotypic resistance to antibiotics, persistence, is not an evolved (selected-for) character but rather like mutation, an inadvertent product of different kinds of errors and glitches. The rate of generation of these errors is augmented by exposure to these drugs. The genes that have been identified as contributing to the production of persisters are analogous to the so-called mutator genes; they modulate the rate at which these errors occur and/or are corrected. In theory, these phenotypically resistant bacteria can retard the rate of microbiological cure by antibiotic treatment.
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