Generation of new compounds through unbalanced transcription of landomycin A cluster

The GenebldA, a Regulator of Morphological Differentiation and Antibiotic Production inStreptomyces

(2015) Stefanie Hackl et al.   ARCHIV DER PHARMAZIE

Metabolic pathway balancing and its role in the production of biofuels and chemicals

(2015) J Andrew Jones et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeted activation of silent natural product biosynthesis pathways by reporter-guided mutant selection

(2015) Fang Guo et al.   METABOLIC ENGINEERING

Minimum Information about a Biosynthetic Gene cluster

(2015) Marnix H Medema et al.   Nature Chemical Biology

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

(2015) Peter J. Rutledge et al.   NATURE REVIEWS MICROBIOLOGY

Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters

(2015) Daniel Montiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overproduction of Ristomycin A by Activation of a Silent Gene Cluster in Amycolatopsis japonicum MG417-CF17

(2014) Marius Spohn et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Iterative marker excision system

(2014) Maksym Myronovskyi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Activation and silencing of secondary metabolites in Streptomyces albus and Streptomyces lividans after transformation with cosmids containing the thienamycin gene cluster from Streptomyces cattleya

(2014) Alfredo F. Braña et al.   ARCHIVES OF MICROBIOLOGY

Genome Mining-Directed Activation of a Silent Angucycline Biosynthetic Gene Cluster inStreptomyces chattanoogensis

(2014) Zhenxing Zhou et al.   CHEMBIOCHEM

Recent advances in natural product discovery

(2014) Yunzi Luo et al.   CURRENT OPINION IN BIOTECHNOLOGY

Pyrronazols, Metabolites from the Myxobacteria Nannocystis pusilla and N. exedens, Are Unusual Chlorinated Pyrone-Oxazole-Pyrroles

(2014) Rolf Jansen et al.   JOURNAL OF NATURAL PRODUCTS

Resistance to oxidative stress via regulating siderophore-mediated iron acquisition by the citrus fungal pathogen Alternaria alternata

(2014) L.-H. Chen et al.   MICROBIOLOGY-SGM

Activation and identification of five clusters for secondary metabolites inStreptomyces albus J1074

(2014) Carlos Olano et al.   Microbial Biotechnology

New natural products as new leads for antibacterial drug discovery

(2013) Dean G. Brown et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes

(2013) Theresa Siegl et al.   METABOLIC ENGINEERING

New strategies for drug discovery: activation of silent or weakly expressed microbial gene clusters

(2012) Kozo Ochi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology

(2012) Madan K Kharel et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis

(2012) Madan K. Kharel et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The construction of a library of synthetic promoters revealed some specific features of strong Streptomyces promoters

(2011) Nicolas Seghezzi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose

(2011) Ki Mo Kim et al.   EXPERIMENTAL CELL RESEARCH

Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis

(2011) Madan K. Kharel et al.   NATURAL PRODUCT REPORTS

Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

(2011) L. Laureti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fungal secondary metabolites – Strategies to activate silent gene clusters

(2010) Axel A. Brakhage et al.   FUNGAL GENETICS AND BIOLOGY

11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain

(2010) Khaled A Shaaban et al.   JOURNAL OF ANTIBIOTICS

Current approaches to exploit actinomycetes as a source of novel natural products

(2010) Olga Genilloud et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Enzymatic Total Synthesis of Rabelomycin, an Angucycline Group Antibiotic

(2010) Madan Kumar Kharel et al.   ORGANIC LETTERS

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Microbial drug discovery: 80 years of progress

(2009) Arnold L Demain et al.   JOURNAL OF ANTIBIOTICS

Coordination of export and glycosylation of landomycins inStreptomyces cyanogenusS136

(2008) Iryna Ostash et al.   FEMS MICROBIOLOGY LETTERS

Genome Sequence of the Streptomycin-Producing Microorganism Streptomyces griseus IFO 13350

(2008) Y. Ohnishi et al.   JOURNAL OF BACTERIOLOGY

Mining microbial genomes for new natural products and biosynthetic pathways

(2008) G. L. Challis   MICROBIOLOGY-SGM