Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter

Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia Cohort

(2019) Toyoda et al.   Cells

Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

(2018) Masahiro Kanai et al.   NATURE GENETICS

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

(2018) Scott M. Jackson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites

(2018) Vyacheslav Akimov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

(2018) Boglárka Zámbó et al.   Scientific Reports

ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study

(2018) Chung-Jen Chen et al.   Scientific Reports

Polymorphisms of the multidrug pump ABCG2: a systematic review of their effect on protein expression, function and drug pharmacokinetics

(2018) Niall Heyes et al.   DRUG METABOLISM AND DISPOSITION

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

(2018) Ioannis Manolaridis et al.   NATURE

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Functional non-synonymous variants of ABCG2 and gout risk

(2017) Blanka Stiburkova et al.   RHEUMATOLOGY

The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion

(2017) Narakorn Khunweeraphong et al.   Scientific Reports

A comprehensive analysis of the association of common variants of ABCG2 with gout

(2017) Kuang-Hui Yu et al.   Scientific Reports

GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

(2016) Akiyoshi Nakayama et al.   ANNALS OF THE RHEUMATIC DISEASES

The C421A (Q141K) polymorphism enhances the 3′-untranslated region (3′-UTR)-dependent regulation of ATP-binding cassette transporter ABCG2

(2016) Anne Ripperger et al.   BIOCHEMICAL PHARMACOLOGY

Jump into a New Fold—A Homology Based Model for the ABCG2/BCRP Multidrug Transporter

(2016) Laura László et al.   PLoS One

Genome-wide association study of clinically defined gout identifies multiple risk loci and its association with clinical subtypes

(2015) Hirotaka Matsuo et al.   ANNALS OF THE RHEUMATIC DISEASES

Novel dysfunctional variant inABCG2as a cause of severe tophaceous gout: biochemical, molecular genetics and functional analysis

(2015) Blanka Stiburkova et al.   RHEUMATOLOGY

Functional Polymorphisms of the ABCG2 Gene Are Associated with Gout Disease in the Chinese Han Male Population

(2014) Danqiu Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of the gout-causing Q141K polymorphism and a CFTR ΔF508 mimicking mutation on the processing and stability of the ABCG2 protein

(2013) Hajnalka Sarankó et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules

(2013) O. M. Woodward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction: Reliable transgene-independent method for determining sleeping beauty transposon copy numbers

(2013) Orsolya Kolacsek et al.   Mobile DNA

Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein

(2012) Ágnes Telbisz et al.   BIOCHEMICAL JOURNAL

Proteomic Analyses Reveal Divergent Ubiquitylation Site Patterns in Murine Tissues

(2012) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

Null alleles of ABCG2 encoding the breast cancer resistance protein define the new blood group system Junior

(2012) Carole Saison et al.   NATURE GENETICS

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

(2012) Anna Köttgen et al.   NATURE GENETICS

Expression Levels of the ABCG2 Multidrug Transporter in Human Erythrocytes Correspond to Pharmacologically Relevant Genetic Variations

(2012) Ildikó Kasza et al.   PLoS One

Decreased extra-renal urate excretion is a common cause of hyperuricemia

(2012) Kimiyoshi Ichida et al.   Nature Communications

Identification of low-frequency variants associated with gout and serum uric acid levels

(2011) Patrick Sulem et al.   NATURE GENETICS

Identification ofABCG2Dysfunction as a Major Factor Contributing to Gout

(2011) H. Matsuo et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Reliable transgene-independent method for determining Sleeping Beauty transposon copy numbers

(2011) Orsolya Kolacsek et al.   Mobile DNA

Arginine 383 is a crucial residue in ABCG2 biogenesis

(2009) Orsolya Polgar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)

(2008) Gergely Szakács et al.   DRUG DISCOVERY TODAY

Major SNP (Q141K) Variant of Human ABC Transporter ABCG2 Undergoes Lysosomal and Proteasomal Degradations

(2008) Tomoka Furukawa et al.   PHARMACEUTICAL RESEARCH